Thursday, November 21, 2024 11/21/2024

Exposures, Health Impacts, and Risk for Mine Waste Contamination

Award Number: P42ES004940
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY (Overall Core: Maier and Zhang) The University of Arizona Superfund Research program (UA SRP) addresses the unique human health risks encountered in the US Southwest, an area with a rich history and future of mining. The Southwest has distinct geologic and climatic attributes that affect human health and exposures to pollution. Groundwater in Southwest regions with rich ore deposits often has elevated arsenic levels, leading to exposure from drinking water. Exposure also occurs by inhalation and ingestion of arsenic-associated mining dusts transported from mining sites into the interior of homes and to exterior environments. Importantly, arsenic exposure has been linked to the development of diabetes. Vulnerable populations residing near mining sites, including Native Americans and Hispanic communities, exhibit increased incidence of diabetes. Our goal is to determine how chronic exposure to mine wastes that contain arsenic contributes to the development of diabetes. We will then use this information to help predict exposures and associated health outcomes as well as to inform public health prevention strategies in communities that neighbor mine waste sites. To achieve this goal, we have five research projects and four cores that will: 1) characterize how chronic mine waste arsenic exposure in mining impacted areas is linked to diabetogenic outcomes through mediation of Nrf2 signaling; 2) determine how the gut microbiome and mining waste mineral properties influence arsenic species transformation, bioavailability, and toxicity; 3) investigate the influence of capping material quality on success of mine waste revegetation to enhance cap and plant remediation technology; 4) model exposures to mining waste contaminants, accounting for socio-demographics, to understand risk factors that drive development of diabetes; 5) mitigate the human impacts of exposure to mining waste through effective interaction with stakeholders including regulators, the mining industry, and affected communities; 6) serve as a global resource for human and environmental health issues associated with metal mining; and 7) train and graduate professionals who are equipped to address complex 21st century environmental hazardous waste problems (Aim 7). The expected outcome of this UA SRP effort is a measurable reduction in diabetes (and other diseases) in mining communities and perhaps beyond.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,079,448 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	35	9/16/2024	NON-COMPETING CONTINUATION	$126,667
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	35	1/30/2024	NON-COMPETING CONTINUATION	$1,952,781
														Subtotal = $2,079,448

Issue Date FY: 2023 ( Subtotal = $2,111,115 )
2023	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	34	7/13/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	34	1/13/2023	NON-COMPETING CONTINUATION	$2,111,115
														Subtotal = $2,111,115

Issue Date FY: 2022 ( Subtotal = $2,111,115 )
2022	2022	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	1/31/2022	NON-COMPETING CONTINUATION	$2,111,115
2022	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	32	10/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,111,115

Issue Date FY: 2021 ( Subtotal = $2,126,465 )
2021	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	32	7/19/2021	SUPPLEMENT FOR EXPANSION	$15,350
2021	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	32	2/1/2021	NON-COMPETING CONTINUATION	$2,111,115
2021	2020	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	31	1/21/2021	COMPETING CONTINUATION	$856,658
2021	2020	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	31	11/26/2020	COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	30	1/21/2021	NON-COMPETING CONTINUATION	-$313,186
2021	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	30	1/21/2021	SUPPLEMENT FOR EXPANSION	-$543,472
														Subtotal = $2,126,465

Issue Date FY: 2020 ( Subtotal = $2,320,495 )
2020	2020	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	31	3/5/2020	COMPETING CONTINUATION	$2,320,495
2020	2020	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	31	3/18/2020	COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	30	1/23/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,320,495

Issue Date FY: 2019 ( Subtotal = $1,846,184 )
2019	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	30	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	30	5/1/2019	NON-COMPETING CONTINUATION	$1,302,712
2019	2019	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	30	9/12/2019	SUPPLEMENT FOR EXPANSION	$543,472
2019	2018	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	29	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,846,184

Issue Date FY: 2018 ( Subtotal = $1,318,901 )
2018	2018	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	29	4/10/2018	NON-COMPETING CONTINUATION	$1,308,209
2018	2018	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	29	5/7/2018	SUPPLEMENT FOR EXPANSION	$10,692
2018	2017	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	28	12/5/2017	COMPETING CONTINUATION	$480,080
2018	2016	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	12/5/2017	NON-COMPETING CONTINUATION	-$469,388
2018	2016	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	27	12/5/2017	SUPPLEMENT FOR EXPANSION	-$10,692
														Subtotal = $1,318,901

Issue Date FY: 2017 ( Subtotal = $1,308,209 )
2017	2017	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	28	8/1/2017	COMPETING CONTINUATION	$1,308,209
2017	2016	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	7/26/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,308,209

Issue Date FY: 2016 ( Subtotal = $2,010,692 )
2016	2016	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	27	6/27/2016	SUPPLEMENT FOR EXPANSION	$10,692
2016	2016	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	5/2/2016	NON-COMPETING CONTINUATION	$2,000,000
														Subtotal = $2,010,692

Issue Date FY: 2015 ( Subtotal = $1,486,286 )
2015	2015	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	25	5/18/2015	SUPPLEMENT FOR EXPANSION	$6,173
2015	2015	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	26	9/24/2015	COMPETING CONTINUATION	$1,480,113
2015	2014	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	25	9/21/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,486,286

Issue Date FY: 2014 ( Subtotal = $2,690,590 )
2014	2014	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	25	7/2/2014	SUPPLEMENT FOR EXPANSION	$8,662
2014	2014	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	25	3/26/2014	NON-COMPETING CONTINUATION	$2,681,928
														Subtotal = $2,690,590

Issue Date FY: 2013 ( Subtotal = $2,607,116 )
2013	2013	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	24	8/20/2013	SUPPLEMENT FOR EXPANSION	$10,000
2013	2013	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	24	8/20/2013	SUPPLEMENT FOR EXPANSION	$10,000
2013	2013	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	24	6/26/2013	NON-COMPETING CONTINUATION	$419,898
2013	2013	UNIVERSITY OF ARIZONA	POST OFFICE BOX 3308	TUCSON	AZ	85722		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	24	5/7/2013	NON-COMPETING CONTINUATION	$2,167,218
														Subtotal = $2,607,116

Issue Date FY: 2012 ( Subtotal = $2,799,021 ) (Continued on the next page)
Grand Total All Awards = $64,351,543

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Exposures, Health Impacts, and Risk for Mine Waste Contamination

Award Number: P42ES004940

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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