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Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands

Award Number: P42ES004911
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1997
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands - OVERALL CENTER SUMMARY/ABSTRACT Support is requested to continue human health-oriented research on risks from exposure to chemicals commonly found in Superfund sites and on remediation technologies to minimize exposure to chemicals from those sites. The pollutants under investigation belong to the halogenated aromatic hydrocarbon family that bind and activate the aryl hydrocarbon receptor (AhR). These chemicals, which include polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and polyaromatic hydrocarbons, are environmentally persistent, lipid soluble contaminants that bioaccumulate in the food chain leading to human and wildlife exposure. A highly integrated, multidisciplinary research program is proposed consisting of five research projects and five supporting cores. The research team includes 25 investigators from Michigan State University (20), Emory University (1), Purdue University (1), Rutgers University (2) and the Michigan Department of Health and Human Services (1). The central overarching theme of the proposed program is to define specific aspects of environmental, microbial and mammalian biomolecular responses to environmental contaminants that act as agonists for the AhR. The major research thrusts will provide new mechanistic information regarding: (1) the diversity and physiogenomic responses of (chloro)dioxin degrading microbial populations indigenous to soils, sediments and groundwater; (2) the geochemical parameters governing adsorbtion, bioavailability and long-term fate of AhR ligands through interactions with geosorbent compositions in soils and sediment components; and (3) the mechanisms of action and computational modeling of interactions between specific biochemical pathways and ligand-activated AhR associated with the liver, thyroid and immune system responses. The Computational Modeling Core (CMC) will develop dynamic computational models of biological responses induced by AhR ligands. An Administrative Core will support research, training, community engagement, data management, and information and technology transfer in this Superfund Research Center (SRC). Within the Administrative Core, research translation will disseminate research findings to target audiences in government, industry and academia. A Community Engagement Core (CEC) will communicate with community stakeholders through engagement with county and city health officials in three new Michigan communities that continue to experience dioxin exposure. A Data Management and Analysis Core will provide the technology, expertise, infrastructure and training necessary to curate datasets, metadata, processing and analyses needed to properly manage and share high quality reproducible data. Lastly, a Research Experience and Training Coordination Core (RETCC) will ensure cross-disciplinary training to pre- and postdoctoral trainees.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	29	4/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,064,068 )
2024	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	29	6/19/2024	NON-COMPETING CONTINUATION	$2,064,068
														Subtotal = $2,064,068

Issue Date FY: 2023 ( Subtotal = $2,097,886 )
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	28	6/29/2023	NON-COMPETING CONTINUATION	$2,097,886
2023	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	2/10/2023	COMPETING CONTINUATION	$0
														Subtotal = $2,097,886

Issue Date FY: 2022 ( Subtotal = $2,131,730 )
2022	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	8/30/2022	COMPETING CONTINUATION	$2,131,730
														Subtotal = $2,131,730

Issue Date FY: 2021 ( Subtotal = -$9,345 )
2021	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	8/21/2021	SUPPLEMENT FOR EXPANSION	-$9,345
														Subtotal = -$9,345

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	4/23/2020	NON-COMPETING CONTINUATION	$0
2020	2017	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	26	6/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $315,647 )
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	26	9/26/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	26	9/12/2019	SUPPLEMENT FOR EXPANSION	$315,647
2019	2018	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	26	3/8/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2017	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	3/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $315,647

Issue Date FY: 2018 ( Subtotal = $2,782,552 )
2018	2018	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	7/13/2018	SUPPLEMENT FOR EXPANSION	$2,782,552
														Subtotal = $2,782,552

Issue Date FY: 2017 ( Subtotal = $2,782,552 )
2017	2017	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	3/22/2017	NON-COMPETING CONTINUATION	$2,555,407
2017	2017	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	26	6/23/2017	NON-COMPETING CONTINUATION	$227,145
														Subtotal = $2,782,552

Issue Date FY: 2016 ( Subtotal = $2,798,369 )
2016	2016	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	25	4/7/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,798,369
														Subtotal = $2,798,369

Issue Date FY: 2015 ( Subtotal = $2,825,922 )
2015	2015	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	24	4/23/2015	NON-COMPETING CONTINUATION	$2,825,922
2015	2014	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	23	7/13/2015	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,825,922

Issue Date FY: 2014 ( Subtotal = $2,825,998 )
2014	2014	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	23	3/31/2014	NON-COMPETING CONTINUATION	$2,776,059
2014	2014	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	23	7/31/2014	SUPPLEMENT FOR EXPANSION	$49,939
														Subtotal = $2,825,998

Issue Date FY: 2013 ( Subtotal = $2,856,051 )
2013	2013	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	22	7/3/2013	COMPETING CONTINUATION	$2,856,051
														Subtotal = $2,856,051

Issue Date FY: 2012 ( Subtotal = $150,000 )
2012	2012	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	21	8/2/2012	SUPPLEMENT FOR EXPANSION	$150,000
2012	2010	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	21	4/4/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $150,000

Issue Date FY: 2011 ( Subtotal = $3,044,988 )
2011	2011	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	21	4/5/2011	SUPPLEMENT FOR EXPANSION	$3,044,988
														Subtotal = $3,044,988

Issue Date FY: 2010 ( Subtotal = $3,107,130 )
2010	2010	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	21	4/1/2010	NON-COMPETING CONTINUATION	$3,107,130
2010	2009	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	20	10/29/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,107,130

Issue Date FY: 2009 ( Subtotal = $3,085,208 )
2009	2009	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	20	8/28/2009	NON-COMPETING CONTINUATION	$31,164
2009	2009	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	20	8/31/2009	NON-COMPETING CONTINUATION	-$109
2009	2009	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	20	3/20/2009	NON-COMPETING CONTINUATION	$3,054,153
2009	2008	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	19	10/31/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,085,208

Issue Date FY: 2008 ( Subtotal = $3,033,899 )
2008	2008	MICHIGAN STATE UNIVERSITY	301 ADMINISTRATION BLDG	EAST LANSING	MI	48824	INGHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	19	3/28/2008	NON-COMPETING CONTINUATION	$3,033,899
														Subtotal = $3,033,899

Issue Date FY: 2007 ( Subtotal = $3,006,609 ) (Continued on the next page)
Grand Total All Awards = $62,648,942

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Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands

Award Number: P42ES004911

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1997

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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