Thursday, November 21, 2024 11/21/2024

Toxic substances in the environment

Award Number: P42ES004705
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

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OVERALL: SUMMARY The UC Berkeley Superfund Research Center, in consultation with the Center’s key stakeholders and advisory boards, has identified six complex and intractable problems associated with hazardous waste sites, namely how to: 1) better assess risks to pregnant women, the fetus and young children; 2) protect disadvantaged communities; 3) understand the totality of chemicals communities are exposed to; 4) account for interactions between mixtures of chemicals; 5) perform on site in situ remediation without depleting valuable resources or transporting contaminated soil to other locations; and, 6) destroy persistent chemicals that are resistant to remediation. Four interactive projects (2 biomedical and 2 engineering) and 4 required cores are proposed to address these six problems though original research. Our proposed research and community engagement efforts aim to provide information and tools that will help solve these complex problems associated with Superfund contaminants and address the four mandates of the Superfund Research Program (SRP). The proposed interdisciplinary projects and cores of the UC Berkeley Center are all designed to address one or more of the four mandates as applied to chemicals high on ATSDR’s Superfund priority list, of importance to the US EPA’s Programs, and of concern to other stakeholders, including arsenic, chromium and other metals, PFAS and other halogenated contaminants. Our overall goal is to improve the remediation and understanding of the health effects of mixtures of Superfund contaminants. To achieve this, we propose to take a systems approach, a problem-solving paradigm grounded in public health concepts. Together with our Stakeholders, we will collectively form an understanding of some of the issues they face and create a bidirectional dialogue between us. We will attempt to perform basic research that informs action, learning and refining as we go. This ‘systems’ approach is central to improving public health. It is an approach that has been widely used in many public health settings and will be used as the central paradigm within our Center. Biomedical Projects 1 and 2 with the DMAC will study the effects of mixtures of contaminants on perinatal outcomes and the developing immune system. Engineering Projects 3 and 4 will develop a complementary treatment approach consisting of in situ chemical treatment in combination with biological radical systems to remediate a broad range of PFAS and other highly persistent halogenated pollutants. With Core A they will also assess the fate of the transformation products generated by the treatment process and their potential for toxicity. Core B in collaboration with Projects 1, 4 and the DMAC will address drinking water quality problems in California that exist despite sophisticated statewide water infrastructure and federal water quality laws. Core C (DMAC) will manage, store and share data from all projects and cores using FAIR guidelines and assist in the biostatistical analysis of all project-generated data. Core D will provide all trainees with trans-disciplinary education, and training in environmental health, toxicology and environmental engineering.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,657,814 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	36	6/27/2024	NON-COMPETING CONTINUATION	$1,617,750
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	36	8/13/2024	SUPPLEMENT FOR EXPANSION	$10,536
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	36	7/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	36	6/28/2024	SUPPLEMENT FOR EXPANSION	$39,464
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	35	3/22/2024	NON-COMPETING CONTINUATION	$0
2024	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	10/1/2023	NON-COMPETING CONTINUATION	-$9,936
														Subtotal = $1,657,814

Issue Date FY: 2023 ( Subtotal = $1,661,169 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	35	6/29/2023	NON-COMPETING CONTINUATION	$1,622,280
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	35	7/6/2023	SUPPLEMENT FOR EXPANSION	$50,000
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	35	7/6/2023	NON-COMPETING CONTINUATION	-$11,111
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	34	11/9/2022	COMPETING CONTINUATION	$0
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	34	6/6/2023	COMPETING CONTINUATION	$291,653
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	6/6/2023	NON-COMPETING CONTINUATION	-$291,653
														Subtotal = $1,661,169

Issue Date FY: 2022 ( Subtotal = $1,848,270 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	34	8/25/2022	COMPETING CONTINUATION	$1,848,270
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	11/9/2021	NON-COMPETING CONTINUATION	$0
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	8/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,848,270

Issue Date FY: 2021 ( Subtotal = $2,397,655 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	9/23/2021	NON-COMPETING CONTINUATION	$0
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	4/12/2021	NON-COMPETING CONTINUATION	$2,397,655
														Subtotal = $2,397,655

Issue Date FY: 2020 ( Subtotal = $2,144,649 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	32	9/30/2020	NON-COMPETING CONTINUATION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	32	3/31/2020	NON-COMPETING CONTINUATION	$2,144,649
														Subtotal = $2,144,649

Issue Date FY: 2019 ( Subtotal = $2,730,045 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	31	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	31	9/12/2019	SUPPLEMENT FOR EXPANSION	$570,847
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	31	4/22/2019	NON-COMPETING CONTINUATION	$2,159,198
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	30	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,730,045

Issue Date FY: 2018 ( Subtotal = $2,204,816 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	30	5/8/2018	SUPPLEMENT FOR EXPANSION	$9,936
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	30	4/17/2018	NON-COMPETING CONTINUATION	$2,145,381
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	009	30	9/10/2018	SUPPLEMENT FOR EXPANSION	$49,500
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	29	5/3/2018	COMPETING CONTINUATION	-$2,157,303
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	29	5/3/2018	SUPPLEMENT FOR EXPANSION	-$8,640
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	29	5/7/2018	SUPPLEMENT FOR EXPANSION	$8,640
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	29	5/7/2018	COMPETING CONTINUATION	$2,157,303
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	008	29	6/1/2018	COMPETING CONTINUATION	$239,628
2018	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	28	6/1/2018	SUPPLEMENT FOR EXPANSION	-$239,628
2018	2015	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	12/5/2017	NON-COMPETING CONTINUATION	-$1
														Subtotal = $2,204,816

Issue Date FY: 2017 ( Subtotal = $2,165,943 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	29	9/7/2017	COMPETING CONTINUATION	$215,062
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	29	6/30/2017	COMPETING CONTINUATION	$1,942,241
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	29	7/1/2017	SUPPLEMENT FOR EXPANSION	$8,640
														Subtotal = $2,165,943

Issue Date FY: 2016 ( Subtotal = $2,525,616 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	28	9/21/2016	SUPPLEMENT FOR EXPANSION	$275,612
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	8/8/2016	SUPPLEMENT FOR EXPANSION	$2,250,004
														Subtotal = $2,525,616

Issue Date FY: 2015 ( Subtotal = $2,687,374 )
2015	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	3/27/2015	NON-COMPETING CONTINUATION	$2,687,374
														Subtotal = $2,687,374

Issue Date FY: 2014 ( Subtotal = $2,710,001 ) (Continued on the next page)
Grand Total All Awards = $77,483,471

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Toxic substances in the environment

Award Number: P42ES004705

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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