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Biomarkers of Exposure to Hazardous Substances

Award Number: P42ES004699
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Biomarkers of Exposure to Hazardous Substances - ABSTRACT: UC DAVIS SUPERFUND RESEARCH PROGRAM Superfund sites are diverse, and many include unknown chemicals, chemicals of unknown toxicity and/or toxic degradation products. Currently, methods to detect, prioritize, and remediate these chemicals are incomplete or nonexistent. The UC Davis Superfund Research Center (UCD-SRC) will conduct research to: (i) improve understanding of the mechanisms by which hazardous chemicals produce adverse health effects, (ii) develop, validate and integrate novel methods to evaluate chemical exposures, levels of contamination, and health risks, and (iii) develop innovative remediation strategies to reduce hazardous substance exposure and toxicity. To achieve these goals the SRC consists of 5 integrated projects, 2 research support cores, a training core, a community engagement core, a research translation core and an administrative core. The UCD-SRC will use integrated chromatographic, biosensor and cell based technologies to detect and identify contaminants and develop innovative approaches for bioremediation. Rapid immunochemical and cell based analysis will supplement classical technologies for the evaluation of sites, as well as determining human susceptibility, exposure and effect. Fundamental mechanisms of toxic action of selected chemicals will be explored to predict risk and develop new biomarkers. This mechanistic knowledge will be extended in vivo with an emphasis on mechanism of toxicity. We are expanding the use of transcriptomics, proteomics, metabolomics and integrated bioinformatics technologies to discover new mechanisms of action of hazardous materials and biomarkers for their action and to connect hazardous substance exposures to organism level effects. The biomarkers developed in this project will serve as biological dosimeters in exposure studies. All aspects of the program will be connected to our Community Engagement Core, and subject to community approval will be demonstrated on Yurok Tribal Lands. Technologies developed by the SRC will be tested at field sites and transferred to end users through a research translation core. Program Relevance We will develop sensitive systems for evaluating and mitigating the risk of hazardous chemicals on human populations and the environment using biomarkers of both exposure and effect.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	10/12/2023	NON-COMPETING CONTINUATION	$0
2024	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	4/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	3/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,473,196 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	7/19/2021	SUPPLEMENT FOR EXPANSION	$8,625
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	4/2/2021	NON-COMPETING CONTINUATION	$2,464,571
														Subtotal = $2,473,196

Issue Date FY: 2020 ( Subtotal = $2,216,418 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	32	7/13/2020	SUPPLEMENT FOR EXPANSION	$7,312
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	32	6/3/2020	NON-COMPETING CONTINUATION	$2,209,106
														Subtotal = $2,216,418

Issue Date FY: 2019 ( Subtotal = $2,843,223 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	31	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	31	9/12/2019	SUPPLEMENT FOR EXPANSION	$636,786
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	31	4/17/2019	NON-COMPETING CONTINUATION	$2,206,437
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	30	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,843,223

Issue Date FY: 2018 ( Subtotal = $2,286,775 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	30	5/31/2018	SUPPLEMENT FOR EXPANSION	$49,500
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	30	4/10/2018	NON-COMPETING CONTINUATION	$2,237,275
														Subtotal = $2,286,775

Issue Date FY: 2017 ( Subtotal = $2,178,839 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	29	8/9/2017	COMPETING CONTINUATION	-$2,178,840
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	29	8/11/2017	COMPETING CONTINUATION	$2,178,840
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	29	6/30/2017	COMPETING CONTINUATION	$2,178,840
2017	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	28	9/11/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	28	9/11/2017	SUPPLEMENT FOR EXPANSION	-$1
														Subtotal = $2,178,839

Issue Date FY: 2016 ( Subtotal = $299,666 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	2/22/2016	SUPPLEMENT FOR EXPANSION	$299,666
2016	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	28	5/13/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $299,666

Issue Date FY: 2015 ( Subtotal = $10,762 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	5/1/2015	SUPPLEMENT FOR EXPANSION	$10,762
														Subtotal = $10,762

Issue Date FY: 2014 ( Subtotal = $2,531,819 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	1/27/2014	SUPPLEMENT FOR EXPANSION	$35,699
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	28	3/28/2014	NON-COMPETING CONTINUATION	$2,496,120
														Subtotal = $2,531,819

Issue Date FY: 2013 ( Subtotal = $2,429,524 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	27	5/7/2013	NON-COMPETING CONTINUATION	$2,035,202
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	27	6/25/2013	NON-COMPETING CONTINUATION	$394,322
														Subtotal = $2,429,524

Issue Date FY: 2012 ( Subtotal = $2,587,449 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	3/28/2012	NON-COMPETING CONTINUATION	$2,587,449
														Subtotal = $2,587,449

Issue Date FY: 2011 ( Subtotal = $2,774,310 )
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	25	4/5/2011	NON-COMPETING CONTINUATION	$2,774,310
														Subtotal = $2,774,310

Issue Date FY: 2010 ( Subtotal = $2,461,363 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	24	6/10/2010	SUPPLEMENT FOR EXPANSION	$7,500
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	24	5/11/2010	SUPPLEMENT FOR EXPANSION	$14,200
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	24	4/15/2010	COMPETING CONTINUATION	$2,439,663
														Subtotal = $2,461,363

Issue Date FY: 2009 ( Subtotal = $3,084,043 ) (Continued on the next page)
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	003	23	7/10/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	23	6/19/2009	SUPPLEMENT FOR EXPANSION	$14,200
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	002	23	5/29/2009	SUPPLEMENT FOR EXPANSION	$45,900
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	23	3/25/2009	NON-COMPETING CONTINUATION	$2,588,040
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	006	23	9/15/2009	SUPPLEMENT FOR EXPANSION	$213,514
Grand Total All Awards = $53,750,049

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Biomarkers of Exposure to Hazardous Substances

Award Number: P42ES004699

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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