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Effects-Related Biomarkers of Environmental Neurotoxic Exposures

Award Number: P42ES004696
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY This proposal is for a 5-year competing renewal of the University of Washington (UW) Superfund Research Program (SRP). The overarching theme of the program is to investigate the mechanisms and ramifications of metal neurotoxicity in humans and aquatic species. Based upon our work, we are developing biomarkers predictive of; 1) exposure to neurotoxic agents, 2) early indicators of neurotoxic injury at the cellular and organismal levels, and/or 3) genetic determinants that underlie unusual susceptibility to environmental neurotoxicants. The physiological processes under investigation adversely affect cognition, olfaction and neurobehavioral processes, and are associated with the risk of developing Alzheimer's and non-Alzheimer's related dementia, Parkinson's disease, and other neurodevelopmental diseases. Our research focuses upon metals that commonly occur at Superfund hazardous waste sites for which there are important data gaps impeding the full understanding of their neurotoxic effects on human health and aquatic species. These data gaps include an understanding of mechanisms of toxicity, inter-individual or gender susceptibility, and biogeochemical factors that govern their fate in their environment. A key theme of our projects is addressing the role of cellular oxidative stress during metal-induced neurotoxicity. The UW program will include four research projects (two environmental science and two biomedical projects). The research projects include investigations of (1) mechanisms and biomarkers of metal olfactory injury to Pacific salmon, with a primary focus on cadmium; (2) cellular and molecular mechanisms of cadmium-mediated neurotoxicity in rodents, including effects on olfaction and cognition; (3) the role of paraoxonases as modifiers of cadmium and manganese neurotoxicity; and (4) biogeochemistry and bioavailability of arsenic in an urbanized lake system in Washington State. Our projects include collaborations among projects and cores, and each project is interdisciplinary in nature. The UW SRP includes a Training Core that is multi- and interdisciplinary, and will support predoctoral trainees from participating departments. The Research Translation Core will continue to ensure timely and appropriate communication of our research findings to NIEHS and other appropriate stakeholders, partner effectively with agencies, identify potential patents, and develop and support translation opportunities with other end-users of our scientific findings. The Community Engagement Core (a new Core beginning with 2015 funding) will build upon existing partnerships and expand partnerships with other communities, such as those directly affected by the toxicants we are studying, and with other community groups that have concerns about environmental toxicants. The Administrative Core will stimulate interactions among projects and cores ensuring full program integration, assure appropriate communication with NIEHS and other governmental agencies, oversee personnel and budgetary matters, and organize meetings and interactions with the Internal Executive Committee and the External Advisory Board.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$24,468 )
2024	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	11/8/2023	NON-COMPETING CONTINUATION	-$24,468
														Subtotal = -$24,468

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	33	4/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,229,662 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	33	4/27/2021	NON-COMPETING CONTINUATION	$2,229,662
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	33	9/22/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	32	11/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,229,662

Issue Date FY: 2020 ( Subtotal = $2,007,142 )
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	32	4/3/2020	NON-COMPETING CONTINUATION	$1,996,342
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	32	6/4/2020	SUPPLEMENT FOR EXPANSION	$10,800
2020	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	31	12/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,007,142

Issue Date FY: 2019 ( Subtotal = $2,053,967 )
2019	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	31	3/18/2019	NON-COMPETING CONTINUATION	$2,004,467
2019	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	30	2/27/2019	SUPPLEMENT FOR EXPANSION	$49,500
2019	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	30	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,053,967

Issue Date FY: 2018 ( Subtotal = $1,986,481 )
2018	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	30	3/22/2018	NON-COMPETING CONTINUATION	$1,986,481
2018	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	29	12/5/2017	COMPETING CONTINUATION	-$773
2018	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	29	11/3/2017	COMPETING CONTINUATION	$193,051
2018	2016	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	28	12/5/2017	NON-COMPETING CONTINUATION	$773
2018	2016	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	11/3/2017	NON-COMPETING CONTINUATION	-$193,051
														Subtotal = $1,986,481

Issue Date FY: 2017 ( Subtotal = $1,988,065 )
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	29	7/19/2017	SUPPLEMENT FOR EXPANSION	$10,800
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	29	6/30/2017	COMPETING CONTINUATION	$1,977,265
2017	2016	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	6/29/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,988,065

Issue Date FY: 2016 ( Subtotal = $1,952,511 )
2016	2016	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	28	4/15/2016	NON-COMPETING CONTINUATION	$1,952,511
														Subtotal = $1,952,511

Issue Date FY: 2015 ( Subtotal = $1,521,450 )
2015	2015	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	27	9/24/2015	COMPETING CONTINUATION	$1,521,450
2015	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	26	9/21/2015	NON-COMPETING CONTINUATION	$0
2015	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	4/1/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,521,450

Issue Date FY: 2014 ( Subtotal = $150,000 )
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	5/12/2014	SUPPLEMENT FOR EXPANSION	$150,000
														Subtotal = $150,000

Issue Date FY: 2013 ( Subtotal = $2,195,825 )
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	5/7/2013	NON-COMPETING CONTINUATION	$1,839,434
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	26	6/25/2013	NON-COMPETING CONTINUATION	$356,391
														Subtotal = $2,195,825

Issue Date FY: 2012 ( Subtotal = $2,306,175 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	25	3/30/2012	NON-COMPETING CONTINUATION	$2,306,175
														Subtotal = $2,306,175

Issue Date FY: 2011 ( Subtotal = $2,522,099 )
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	23	1/14/2011	SUPPLEMENT FOR EXPANSION	$20,000
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	24	4/7/2011	NON-COMPETING CONTINUATION	$2,327,099
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	24	9/27/2011	SUPPLEMENT FOR EXPANSION	$175,000
														Subtotal = $2,522,099

Issue Date FY: 2010 ( Subtotal = $2,511,285 )
2010	2010	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	23	9/23/2010	SUPPLEMENT FOR EXPANSION	$168,872
2010	2010	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	23	9/24/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2010	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	23	4/20/2010	NON-COMPETING CONTINUATION	$2,342,413
2010	2009	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	22	2/23/2010	COMPETING CONTINUATION	$0
														Subtotal = $2,511,285

Issue Date FY: 2009 ( Subtotal = $2,465,820 ) (Continued on the next page)
2009	2009	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	22	8/28/2009	SUPPLEMENT FOR EXPANSION	$50,000
Grand Total All Awards = $56,868,002

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Effects-Related Biomarkers of Environmental Neurotoxic Exposures

Award Number: P42ES004696

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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