Tuesday, July 1, 2025 7/1/2025

Gene Expression Database for Mouse Development

Award Number: P41HD062499
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/02/2010
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Gene Expression Database for Mouse Development - Abstract – OVERALL COMPONENT The goal of this application is the continued development and maintenance of the Gene Expression Database for Mouse Development (GXD). GXD is a well-established community resource. It integrates different types of expression data including biologically complex data, such as RNA in situ hybridization and immunohistochemistry results, and high-throughput expression data from RNA-seq experiments. It places these data in the larger biological context through integration with other Mouse Genome Informatics (MGI) resources and interconnections with many other databases, supporting complex queries that enable thorough biological and computational analyses. The specific aims of this proposal are (1) to continue and expand GXD’s curation of expression data and anatomical ontologies and ensure high-quality data annotation and integration. We will continue to curate data from RNA in situ hybridization, in situ-reporter knock-in, immunohistochemistry, RT-PCR, Northern blot and Western blot experiments; and expand our annotation of bulk and single-cell RNA-seq data sets. We will enhance the mouse anatomy ontology, and refine our expression annotations by combining anatomy and cell type terms. We will (2) maintain the GXD database and enhance GXD’s infrastructure and data entry interfaces to accommodate large volumes of expression data and to represent new types of data and relationships. We will enhance the database and software infrastructure to accommodate the expected increase in RNA-seq data. We will expand the database to represent anatomical differentiation pathways, as well as expression annotations to cell type terms. We will continue to modernize the editorial interface and expand the interface as needed for the annotation of new data types. We will automate more steps of the literature selection process to increase curation efficiency. We will (3) continue to evolve GXD’s user interface and develop advanced query and display tools. We will develop expression searches that allow the analysis of anatomical differentiation pathways and cell types. We will add support for quantitative expression analyses, comparisons and profiling. We will develop displays that superimpose expression data with molecular pathway and protein interaction data to support the analysis of molecular networks with co- expression information. We will (4) provide user support and promote use of GXD by the scientific community. We will continue to provide training and to solicit feedback on how we can improve GXD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,234,990 )
2025	2025	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	15	4/4/2025	NON-COMPETING CONTINUATION	$2,234,990
														Subtotal = $2,234,990

Issue Date FY: 2024 ( Subtotal = $2,234,990 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	14	4/30/2024	NON-COMPETING CONTINUATION	$2,234,990
														Subtotal = $2,234,990

Issue Date FY: 2023 ( Subtotal = $2,234,990 )
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	13	4/11/2023	NON-COMPETING CONTINUATION	$2,146,600
2023	2023	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	13	8/30/2023	NON-COMPETING CONTINUATION	$88,390
														Subtotal = $2,234,990

Issue Date FY: 2022 ( Subtotal = $2,146,600 )
2022	2022	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	002	12	4/26/2022	NON-COMPETING CONTINUATION	$2,146,600
2022	2021	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	11	11/29/2021	COMPETING CONTINUATION	$53
2022	2020	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	10	11/29/2021	NON-COMPETING CONTINUATION	-$53
														Subtotal = $2,146,600

Issue Date FY: 2021 ( Subtotal = $2,146,600 )
2021	2021	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	11	5/28/2021	COMPETING CONTINUATION	$2,146,600
2021	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	10	11/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,146,600

Issue Date FY: 2020 ( Subtotal = $2,100,000 )
2020	2020	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	10	4/22/2020	NON-COMPETING CONTINUATION	$2,100,000
														Subtotal = $2,100,000

Issue Date FY: 2019 ( Subtotal = $2,100,000 )
2019	2019	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	9	4/25/2019	NON-COMPETING CONTINUATION	$2,100,000
2019	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	8	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,100,000

Issue Date FY: 2018 ( Subtotal = $2,100,000 )
2018	2018	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	8	4/26/2018	NON-COMPETING CONTINUATION	$2,100,000
														Subtotal = $2,100,000

Issue Date FY: 2017 ( Subtotal = $2,100,000 )
2017	2017	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	7	6/21/2017	NON-COMPETING CONTINUATION	$209,998
2017	2017	THE JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	7	4/24/2017	NON-COMPETING CONTINUATION	$1,890,002
														Subtotal = $2,100,000

Issue Date FY: 2016 ( Subtotal = $2,100,000 )
2016	2016	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	002	6	6/30/2016	COMPETING CONTINUATION	$2,100,000
2016	2015	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	046091500	HANCOCK	USA	Child Health and Human Development Extramural Research	001	5	6/24/2016	NON-COMPETING CONTINUATION	$0
2016	2015	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	046091500	HANCOCK	USA	Child Health and Human Development Extramural Research	000	5	11/25/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,100,000

Issue Date FY: 2015 ( Subtotal = $2,322,218 )
2015	2015	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	5	11/18/2014	NON-COMPETING CONTINUATION	$2,089,995
2015	2015	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	5	1/15/2015	NON-COMPETING CONTINUATION	$232,223
														Subtotal = $2,322,218

Issue Date FY: 2014 ( Subtotal = $2,249,679 )
2014	2014	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	4	11/21/2013	NON-COMPETING CONTINUATION	$2,083,036
2014	2014	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	4	2/19/2014	NON-COMPETING CONTINUATION	$166,643
														Subtotal = $2,249,679

Issue Date FY: 2013 ( Subtotal = $2,191,261 )
2013	2013	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	3	5/15/2013	NON-COMPETING CONTINUATION	$113,142
2013	2013	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	3	12/12/2012	NON-COMPETING CONTINUATION	$2,078,119
														Subtotal = $2,191,261

Issue Date FY: 2012 ( Subtotal = $2,261,470 )
2012	2012	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	2	12/6/2011	NON-COMPETING CONTINUATION	$2,071,574
2012	2012	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	001	2	2/15/2012	NON-COMPETING CONTINUATION	$189,896
														Subtotal = $2,261,470

Issue Date FY: 2011 ( Subtotal = $2,282,840 )
2011	2011	JACKSON LABORATORY (THE)	600 MAIN STREET	BAR HARBOR	ME	04609	HANCOCK	USA	Child Health and Human Development Extramural Research	000	1	12/1/2010	NEW	$2,282,840
														Subtotal = $2,282,840

Grand Total All Awards = $32,805,638

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Gene Expression Database for Mouse Development

Award Number: P41HD062499

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/02/2010

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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