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Tissue Engineering Resource Center

Award Number: P41EB027062
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Tissue Engineering Resource Center - Tissue engineering is rapidly developing, but remains limited by (i) scaffold and bioreactor designs that are based on predetermined parameters, and (ii) the lack of real-time, nondestructive measurements of cell and tissue function. To overcome these two limitations, we will develop adaptive-responsive biomaterials that can sense environmental signals and actuate the cells, and imaging-enabled bioreactors with real-time spatiotemporal control of engineered tissues with feedback from the measured cell responses. Our goal is to offer these advances to the tissue engineering community and translate them into clinics. The proposed renewal of the Tissue Engineering Resource Center (TERC) brings together a highly productive interdisciplinary team of actively collaborating investigators from Columbia University (lead institution), Tufts University, Columbia University Irving Medical Center and Stevens Institute of Technology. An Administrative Board will coordinate the Center’s activities, with the oversight and guidance of an exceptionally strong External Advisory Committee, formed from the world leaders in tissue engineering and clinical translation. TERC will partner with a number of existing resources (please see 18 letters of support), and will benefit from the exceptional resources provided by our institutions and the very generous financial support of the Columbia University School of Engineering ($2,125,000 over the five-year cycle). The technical components of the Center are three Technology Research and Development Projects (TR&D1: Adaptive-responsive biomaterials; TR&D2: Imaging enabled bioreactors; TR&D3: Translational technologies), 17 Collaborative Projects, and 16 Service Projects. We also propose a robust training program for biomedical investigators to facilitate the use of new technologies and raise awareness about TERC, and comprehensive outreach to the general public. With a highly innovative scientific premise, extensive foundational research, strong leadership and institutional support, experience in translational research, and long history of collaboration among the lead investigators, we are confident that the Center will accomplish its mission of serving as a transformative driving force in the field of tissue engineering.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,335,406 )
2026	2026	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	3/9/2026	NON-COMPETING CONTINUATION	$1,335,406
														Subtotal = $1,335,406

Issue Date FY: 2025 ( Subtotal = $1,349,983 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	8/14/2025	NON-COMPETING CONTINUATION	$1,349,983
2025	2023	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	2/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,349,983

Issue Date FY: 2024 ( Subtotal = $1,255,354 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	6/6/2024	COMPETING CONTINUATION	$1,255,354
														Subtotal = $1,255,354

Issue Date FY: 2023 ( Subtotal = $1,406,288 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	7/21/2023	SUPPLEMENT FOR EXPANSION	$90,651
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	7/13/2023	NON-COMPETING CONTINUATION	$1,315,637
														Subtotal = $1,406,288

Issue Date FY: 2022 ( Subtotal = $1,380,704 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	9/6/2022	SUPPLEMENT FOR EXPANSION	$60,435
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	8/13/2022	NON-COMPETING CONTINUATION	$1,334,514
2022	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	1/31/2022	SUPPLEMENT FOR EXPANSION	-$14,245
														Subtotal = $1,380,704

Issue Date FY: 2021 ( Subtotal = $1,315,331 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	6/18/2021	NON-COMPETING CONTINUATION	$1,315,331
														Subtotal = $1,315,331

Issue Date FY: 2020 ( Subtotal = $1,816,617 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/8/2020	NON-COMPETING CONTINUATION	$1,349,613
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	7/27/2020	SUPPLEMENT FOR EXPANSION	$467,004
														Subtotal = $1,816,617

Issue Date FY: 2019 ( Subtotal = $1,372,336 )
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	9/18/2019	NEW	-$1,372,336
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	1	9/19/2019	NEW	$1,372,336
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/16/2019	NEW	$1,372,336
														Subtotal = $1,372,336

Grand Total All Awards = $11,232,019

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Tissue Engineering Resource Center

Award Number: P41EB027062

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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