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Resource for Quantitative Functional FMRI

Award Number: P41EB015909
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2000
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Resource for Quantitative Functional FMRI - OVERALL RESOURCE: Summary The Resource for Quantitative Functional Magnetic Resonance Imaging is an interdepartmental and interdisciplinary Resource combining facilities of the F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute (KKI), the Center for Imaging Science (CIS) in the School of Engineering at Johns Hopkins University (JHU), and the group for Imaging Biostatistics in the Bloomberg School of Public Health at JHU. This Resource Center is dedicated to using its unique expertise to design novel MRI and MRS data acquisition and processing technology in order to facilitate the biomedical research of a large community of clinicians and neuroscientists in Maryland and throughout the USA, with a special focus on the changing brain throughout our life span, i.e. during neurodevelopment as well as during neurodegeneration. These NIH- funded collaborative projects have a continued need for the development of new quantitative technology to better achieve and further expand the aims in their grants, which focus on topics such as autism, impaired brain development, attention deficit hyperactivity disorder, Alzheimer's disease, multiple sclerosis, schizophrenia, primary progressive aphasia, Huntington's disease and cancer. The F.M. Kirby Center is a leading magnetic resonance technology development center that has 3T and 7T state of the art scanners equipped with parallel imaging capabilities (8, 16, and 32-channel receive coils), and a dual transmit body coil at 3T. The 7T is to be extended with a 8-channel multi-transmit system with a compatible 32-channel coil. CIS is an interdisciplinary research center that brings together a diverse group of scientists whose work rests on theoretical advances in mathematics and statistics, traditional signal and systems processing, and information theory. This Center has an IBM supercomputer that is part of a national supercomputing infrastructure. The Department of Biostatistics at the Johns Hopkins Bloomberg School of Public Health has one of the largest groups of biostatisticians focusing on neuroimaging. This Department also boasts a world class computing environment with its high performance computing cluster. Our Resource combines a strong technical environment with unique expertise of the investigators and clinicians in our collaborative projects, who are continuously asking questions to improve technology for their studies in children, the elderly, and subjects with neurological and psychiatric disorders. These needs are reflected in the proposed developments in our four technical research and development (TR&D) projects. TR&D1 focuses on MR spectroscopy (MRS) assessment of tissue changes in metabolite levels; TR&D2 develops MRI methods for detection of glutamate, cerebral blood volume (CBV), flow (CBF), metabolic rate of oxygen (CMRO2), and tissue structure iron and myelin content as reflected in magnetic susceptibility parameters. In TR&D3, new statistical approaches are developed for studying functional connectivity. The methodologies of TR&Ds 1-3 are brought together in TR&D4, where multi-contrast brain atlases are being designed that can be used to study the measured parameters, while taking into account changes in the brain shape. Together with the collaborators we optimize the new approaches to turn them into practical products. The resource provides training in these new acquisition and processing technologies and has a longstanding history of disseminating them to other research centers and hospitals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$125,420 )
2024	2020	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	20	3/28/2024	NON-COMPETING CONTINUATION	-$125,420
														Subtotal = -$125,420

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	20	7/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,379,441 )
2020	2020	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	20	8/14/2020	NON-COMPETING CONTINUATION	$1,379,441
														Subtotal = $1,379,441

Issue Date FY: 2019 ( Subtotal = $1,379,441 )
2019	2019	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	19	8/15/2019	NON-COMPETING CONTINUATION	$1,379,441
														Subtotal = $1,379,441

Issue Date FY: 2018 ( Subtotal = $1,783,344 )
2018	2018	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	18	7/6/2018	NON-COMPETING CONTINUATION	$1,379,441
2018	2018	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	18	9/13/2018	SUPPLEMENT FOR EXPANSION	$403,903
														Subtotal = $1,783,344

Issue Date FY: 2017 ( Subtotal = $1,379,001 )
2017	2017	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	17	7/27/2017	NON-COMPETING CONTINUATION	$1,379,001
2017	2016	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	16	3/1/2017	COMPETING CONTINUATION	$625,476
2017	2015	HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC.	707 N BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	15	3/1/2017	NON-COMPETING CONTINUATION	-$625,476
														Subtotal = $1,379,001

Issue Date FY: 2016 ( Subtotal = $1,876,065 )
2016	2016	HUGO W MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER INC	707 NORTH BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	16	9/16/2016	COMPETING CONTINUATION	$1,876,065
														Subtotal = $1,876,065

Issue Date FY: 2015 ( Subtotal = $1,344,086 )
2015	2015	HUGO W MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER INC	707 NORTH BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	15	8/26/2015	NON-COMPETING CONTINUATION	$1,344,086
														Subtotal = $1,344,086

Issue Date FY: 2014 ( Subtotal = $1,330,370 )
2014	2014	HUGO W MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER INC	707 NORTH BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	14	8/27/2014	NON-COMPETING CONTINUATION	$1,330,370
														Subtotal = $1,330,370

Issue Date FY: 2013 ( Subtotal = $1,293,340 )
2013	2013	HUGO W MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER INC	707 NORTH BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	13	9/3/2013	NON-COMPETING CONTINUATION	$1,293,340
														Subtotal = $1,293,340

Issue Date FY: 2012 ( Subtotal = $1,371,516 )
2012	2012	HUGO W MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER INC	707 NORTH BROADWAY	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	8/28/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,371,516
														Subtotal = $1,371,516

Grand Total All Awards = $13,011,184

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Resource for Quantitative Functional FMRI

Award Number: P41EB015909

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2000

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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