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The Procurement of BioAnalyzers to Expedite and Enhance Services Provided by the National Natural Toxins Research Center

Award Number: P40OD010960
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The Procurement of BioAnalyzers to Expedite and Enhance Services Provided by the National Natural Toxins Research Center - PROJECT SUMMARY: Natural products have been a foundation of drug design, and snakes and other animal venoms have vast potential. Snake venoms have provided molecular probes that have been used to decipher numerous complex physiological and pathophysiological processes and have served as the starting point for developing several important classes of drugs. The venom and anti-venom research fields depend on access to reliable and reproducible venom-related resources developed by the National Natural Toxin Research Center (NNTRC). The NNTRC requires equipment and instrumentation for storing crude snake venoms, venom fractions, purified toxins, cloned products, snake and mice tissues, critical reagents (i.e., biochemical assays and reagents, antibodies, conjugated antibodies, and biological samples) used for diverse translational research. The equipment and instrumentation being requested, two ultra-low temperature freezers, a Bio-Plex 200 Multiplex Array System, a DxH 500 Hematology Analyzer, a Stago STA Compact Coagulation Analyzer, and a DM1000 LED upright microscope, in the proposal are ideally suited to support critical research for maintaining the biological samples for long-term storage, analyzing biochemical protein markers in a multiplex format that provide more information from less sample volume in less time than traditional immunoassay methods, determining the hematological variables and coagulation parameters for the characteristic hematological abnormalities observed in snake envenomation. The specific aims of the parent grant are to: 1. Operate the National Natural Toxins Research Center as a resource center that provides high- quality venom and products that support biological and biomedical research to national and international programs. 2. Develop and expand the collection of snakes, specialized services, and outreach programs to support the growth of venom-related research in the U.S. 3. Conduct a state-of-the-art applied research program to support the development of new venom- related research services. Access to this equipment and instruments will enable the NNTRC to fulfill its specific aims and allow researchers to make significant advances in the search for venom-derived therapeutics. RELEVANCE: Venom research is a diverse and multidisciplinary field that encompasses a range of scientific areas, including biochemistry, pharmacology, ecology, and conservation biology. It could lead to the discovery of new drugs, better antivenoms, and an improved understanding of venomous animals and their role in ecosystems. The resources of the NNTRC have been applied to research in a wide range of these disciplines, research that has been supported by multiple NIH I/C’s, the NSF, the Dept of Defense, and national and international research agencies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TEXAS A & M UNIVERSITY KINGSVILLE	700 N UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	21	4/30/2025	COMPETING CONTINUATION	$7,201
2025	2023	TEXAS A & M UNIVERSITY KINGSVILLE	700 N UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	002	20	4/30/2025	SUPPLEMENT FOR EXPANSION	-$1,704
2025	2023	TEXAS A & M UNIVERSITY KINGSVILLE	700 N UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	20	4/30/2025	NON-COMPETING CONTINUATION	-$5,497
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $550,494 )
2024	2024	TEXAS A & M UNIVERSITY KINGSVILLE	700 N UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	21	7/19/2024	COMPETING CONTINUATION	$550,494
2024	2023	TEXAS A & M UNIVERSITY KINGSVILLE	700 N UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	20	7/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $550,494

Issue Date FY: 2023 ( Subtotal = $693,365 )
2023	2023	TEXAS A & M UNIVERSITY KINGSVILLE	700 N UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	20	6/30/2023	SUPPLEMENT FOR EXPANSION	$164,044
2023	2023	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	20	2/18/2023	NON-COMPETING CONTINUATION	$529,321
														Subtotal = $693,365

Issue Date FY: 2022 ( Subtotal = $701,423 )
2022	2022	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	002	19	8/9/2022	SUPPLEMENT FOR EXPANSION	$172,102
2022	2022	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	19	2/9/2022	NON-COMPETING CONTINUATION	$476,388
2022	2022	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	19	5/5/2022	NON-COMPETING CONTINUATION	$52,933
														Subtotal = $701,423

Issue Date FY: 2021 ( Subtotal = $719,184 )
2021	2021	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	18	7/27/2021	SUPPLEMENT FOR EXPANSION	$189,863
2021	2021	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	18	3/9/2021	NON-COMPETING CONTINUATION	$529,321
														Subtotal = $719,184

Issue Date FY: 2020 ( Subtotal = $529,321 )
2020	2020	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	002	17	2/29/2020	NON-COMPETING CONTINUATION	$529,321
2020	2019	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	16	2/3/2020	COMPETING CONTINUATION	$4,035
2020	2018	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	15	2/3/2020	NON-COMPETING CONTINUATION	-$4,035
														Subtotal = $529,321

Issue Date FY: 2019 ( Subtotal = $721,094 )
2019	2019	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	002	16	9/5/2019	SUPPLEMENT FOR EXPANSION	$191,773
2019	2019	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	16	5/23/2019	COMPETING CONTINUATION	$529,321
2019	2018	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	15	5/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $721,094

Issue Date FY: 2018 ( Subtotal = $525,500 )
2018	2018	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	15	6/21/2018	NON-COMPETING CONTINUATION	$52,551
2018	2018	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	15	2/8/2018	NON-COMPETING CONTINUATION	$472,949
														Subtotal = $525,500

Issue Date FY: 2017 ( Subtotal = $524,882 )
2017	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	14	2/16/2017	NON-COMPETING CONTINUATION	$497,256
2017	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	14	8/10/2017	NON-COMPETING CONTINUATION	$27,626
														Subtotal = $524,882

Issue Date FY: 2016 ( Subtotal = $540,214 )
2016	2016	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	13	1/22/2016	NON-COMPETING CONTINUATION	$458,660
2016	2016	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	002	13	7/6/2016	SUPPLEMENT FOR EXPANSION	$30,592
2016	2016	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	13	1/30/2016	NON-COMPETING CONTINUATION	$50,962
														Subtotal = $540,214

Issue Date FY: 2015 ( Subtotal = $634,998 )
2015	2015	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	12	7/25/2015	SUPPLEMENT FOR EXPANSION	$138,880
2015	2015	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	12	2/12/2015	NON-COMPETING CONTINUATION	$496,118
														Subtotal = $634,998

Issue Date FY: 2014 ( Subtotal = $552,798 )
2014	2014	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	002	11	8/29/2014	SUPPLEMENT FOR EXPANSION	$49,835
2014	2014	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	001	11	5/27/2014	COMPETING CONTINUATION	$502,963
2014	2012	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	10	5/26/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $552,798

Issue Date FY: 2013 ( Subtotal = $402,253 )
2013	2013	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	10	5/23/2013	SUPPLEMENT FOR EXPANSION	$402,253
														Subtotal = $402,253

Issue Date FY: 2012 ( Subtotal = $489,552 )
2012	2012	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Research Infrastructure Programs	000	10	5/19/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$489,552
														Subtotal = $489,552

Grand Total All Awards = $7,585,078

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The Procurement of BioAnalyzers to Expedite and Enhance Services Provided by the National Natural Toxins Research Center

Award Number: P40OD010960

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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