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Caenorhabditis Genetics Center

Award Number: P40OD010440
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Caenorhabditis Genetics Center - Project Summary/Abstract—Overall The Caenorhabditis Genetics Center (CGC) is the sole comprehensive repository and distribution center for the nematode Caenorhabditis elegans, a premier model organism for biomedical research studies. The overall objective of this animal resource is to promote research on C. elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers in all 50 states and throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors, as well as for hands-on teaching of experimental science. Studies using C. elegans have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also provided key insights into the cell signaling mechanisms, cancer progression, and neurodegenerative diseases. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the only general stock center for C. elegans, the CGC is an extremely important international research resource, supporting research in these diverse areas and in educational endeavors. The CGC provides about 30,000 strains per year to thousands of laboratories; with a collection of 23,000 unique strains, a number still increasing in proportion to the growth of the field, the CGC not only facilitates research, but also ensures that valuable strains are preserved. Strains are distributed upon request through an on-line ordering system with a scheme of user fees in place to help defray costs and support CGC activities. The CGC closely monitors user needs and devises small research projects to support the community. Because essentially every lab uses fluorescent proteins, and there is demand for brighter, more photostable fluorescent proteins, in more colors to allow multi-plexing, the CGC will develop a pipeline to quantitatively evaluate the in vivo properties of a new set of fluorescent proteins in worm, enabling scientists to choose the optimal versions for their applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $364,235 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	14	2/25/2025	NON-COMPETING CONTINUATION	$364,235
														Subtotal = $364,235

Issue Date FY: 2024 ( Subtotal = $455,294 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	13	5/14/2024	NON-COMPETING CONTINUATION	$91,059
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	13	2/9/2024	NON-COMPETING CONTINUATION	$364,235
														Subtotal = $455,294

Issue Date FY: 2023 ( Subtotal = $455,294 )
2023	2023	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	12	2/18/2023	NON-COMPETING CONTINUATION	$455,294
														Subtotal = $455,294

Issue Date FY: 2022 ( Subtotal = $455,294 )
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	002	11	5/7/2022	COMPETING CONTINUATION	$62,508
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	003	11	6/14/2022	COMPETING CONTINUATION	$0
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	005	11	6/29/2022	COMPETING CONTINUATION	$66,767
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	11	2/23/2022	COMPETING CONTINUATION	$392,786
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	006	11	7/8/2022	COMPETING CONTINUATION	$0
2022	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	004	10	6/29/2022	SUPPLEMENT FOR EXPANSION	-$66,767
2022	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	10	2/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $455,294

Issue Date FY: 2021 ( Subtotal = $519,260 )
2021	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	10	7/27/2021	SUPPLEMENT FOR EXPANSION	$85,647
2021	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	10	2/23/2021	NON-COMPETING CONTINUATION	$433,613
														Subtotal = $519,260

Issue Date FY: 2020 ( Subtotal = $433,613 )
2020	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	9	2/19/2020	NON-COMPETING CONTINUATION	$390,251
2020	2020	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	9	6/9/2020	NON-COMPETING CONTINUATION	$43,362
														Subtotal = $433,613

Issue Date FY: 2019 ( Subtotal = $433,613 )
2019	2019	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	8	2/5/2019	NON-COMPETING CONTINUATION	$433,613
2019	2018	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	7	1/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $433,613

Issue Date FY: 2018 ( Subtotal = $433,613 )
2018	2018	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	7	6/12/2018	NON-COMPETING CONTINUATION	$43,362
2018	2018	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	7	3/1/2018	NON-COMPETING CONTINUATION	$390,251
														Subtotal = $433,613

Issue Date FY: 2017 ( Subtotal = $433,613 )
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	002	6	8/21/2017	COMPETING CONTINUATION	$41,008
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	004	6	8/29/2017	COMPETING CONTINUATION	$8,588
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	6	6/22/2017	COMPETING CONTINUATION	$0
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	6	4/11/2017	COMPETING CONTINUATION	$392,605
2017	2016	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	003	5	8/29/2017	EXTENSION WITH OR WITHOUT FUNDS	-$8,588
														Subtotal = $433,613

Issue Date FY: 2016 ( Subtotal = $433,613 )
2016	2016	UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	5	6/2/2016	EXTENSION WITH OR WITHOUT FUNDS	$433,613
														Subtotal = $433,613

Issue Date FY: 2015 ( Subtotal = $424,941 )
2015	2015	UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	4	4/30/2015	NON-COMPETING CONTINUATION	$424,941
														Subtotal = $424,941

Issue Date FY: 2014 ( Subtotal = $449,277 )
2014	2014	UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	3	9/4/2014	SUPPLEMENT FOR EXPANSION	$20,000
2014	2014	UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	3	6/7/2014	NON-COMPETING CONTINUATION	$429,277
														Subtotal = $449,277

Issue Date FY: 2013 ( Subtotal = $412,368 )
2013	2013	UNIVERSITY OF MINNESOTA	UNIV GATEWAY#450/200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	2	6/10/2013	NON-COMPETING CONTINUATION	$412,368
														Subtotal = $412,368

Issue Date FY: 2012 ( Subtotal = $445,773 )
2012	2012	UNIVERSITY OF MINNESOTA	UNIV GATEWAY#450/200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	000	1	6/28/2012	NEW	$433,613
2012	2012	UNIVERSITY OF MINNESOTA	UNIV GATEWAY#450/200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Research Infrastructure Programs	001	1	8/14/2012	SUPPLEMENT FOR EXPANSION	$12,160
														Subtotal = $445,773

Grand Total All Awards = $6,149,801

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Caenorhabditis Genetics Center

Award Number: P40OD010440

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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