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New York-New Jersey Center for Actionable NeuroHIV Biomarkers and Integrated Omics (NYJ-CAN-BIO)

Award Number: P30MH144896
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/06/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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New York-New Jersey Center for Actionable NeuroHIV Biomarkers and Integrated Omics (NYJ-CAN-BIO) - OVERALL - Summary: The Developmental AIDS Research Center New York-New Jersey – Center for Actionable NeuroHIV Biomarkers and Integrated Omics, (NYJ-CAN-BIO) proposes to develop the infrastructure and collaborative resources at Weill Cornell Medicine (WCM) and Rutgers Health (RH) to enable actionable neuroHIV biomarker driven discovery research. This Center is committed to provide expertise, cutting-edge technologies and training for identifying multidimensional biomarkers that are mechanistically meaningful, diagnostically useful, and translatable towards the development of transformative therapies for HIV-associated CNS dysfunction and strategies focused on the eradication of latent HIV within the CNS. While advances in understanding the pathophysiology of HIV effects on the CNS in the era ART have yielded much progress, current biomarkers are not specific to the CNS, and their utility for biotyping neuroHIV clinical manifestations remains unclear and a significant gap in our efforts to resolve the underlying mechanisms and efforts towards HIV eradication in the CNS. A major barrier to progress in the field is a lack of integrated centralized center to coordinate these efforts. NYJ-CAN-BIO is committed to filing this gap and advance a framework for neuroHIV biomarker discovery, fostering innovation, and promoting collaborative efforts to improve the delineation of CNS disease heterogeneity and clinical outcomes in people with HIV or at risk across the Bi-State (New York and New Jersey) area, a region with one of the highest burdens of HIV across the country. NYJ-CAN-BIO will pioneer biomarker-driven approaches that harness our researchers across two institutions and their basic, clinical and translational infrastructures, integrating cutting-edge technologies, such as 3D organoid and physiological systems, advanced multi-omic platforms and emerging innovations in computational analytics and AI that would ultimately provide a resource and biomarker expertise across the exciting nationwide of DARC and ARC networks beyond the bistate area. The Directors of the Center, Dr. Lishomwa Ndhlovu (WCM) and Dr. Tricia Burdo (RH) and Cores have demonstrated excellence and leadership in neuroHIV and will capitalize on the current expertise of affiliated investigators at WCM and RH through the establishment of an integrated Administrative (AC), Developmental and Mentorship (DMC), and Biosignature (BC) Core structure. To achieve these goals, NYJ-CAN-BIO proposes three aims. Aim 1 will catalyze actionable biomarker-driven neuroHIV research through formation of an AC that integrates translational clinical data with omics driven technologies, computational analytics and 3D brain organoid and physiological system-based modeling across collaborating institutions. Aim 2 will train and support all-encompassing cohorts of early-career, new and established investigators in the emerging fields of neuroHIV, biological indicators of disease, immunology, computational neuroscience, 3D brain organoid and physiological system-based modeling. Aim 3 will guide the discovery, validation, and dissemination of multimodal biomarker discovery omics platforms, computational analytics and human-biology-based new approach methodologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $750,000 )
2026	2026	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Mental Health Research Grants	000	1	8/10/2026	NEW	$750,000
														Subtotal = $750,000

Grand Total All Awards = $750,000

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New York-New Jersey Center for Actionable NeuroHIV Biomarkers and Integrated Omics (NYJ-CAN-BIO)

Award Number: P30MH144896

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/06/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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