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The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)

Award Number: P30HD106451
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC) - Summary (Overall) The Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub will serve as a national resource for multi- disciplinary expertise and knowledge in maternal and pediatric therapeutics. The MPRINT Data, Model, Knowledge, and Research Coordination Center (DMKRCC) will support the MPRINT Centers of Excellence in Therapeutics (CET) and Steering Committee to coordinate and expand research relating to maternal and pediatric therapeutics. The DMKRCC will serve as the administrative component of the MPRINT Hub, coordinate outreach and dissemination of MPRINT Hub activities, and will serve as a conduit between the MPRINT Hub and the broader scientific community. Additionally, the MPRINT DMKRCC will organize annual MPRINT meetings and educational activities, including webinars, to cultivate translational research in maternal and pediatric therapeutics. The DMKRCC will identify, aggregate, and make available data, knowledge, and expertise in maternal and pediatric therapeutics to the wider research, drug development, and regulatory communities. Specifically, the DMKRCC will identify, evaluate, and collate pertinent data in a knowledgebase that will be made available through a web portal; utilize and enhance pharmacometric modeling approaches such as physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD); support clinical trial design; and foster expertise in drug development and personalized therapy for maternal and pediatric populations. The specific aims of this proposal will develop a cohesive organizational structure to support the research of the MPRINT Hub as a whole as well as the individual cores within the DMKRCC. We will develop infrastructure to facilitate data sharing and knowledge dissemination, and work with the CETs and Steering Committee to identify and address changing needs of the maternal and pediatric communities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	000	4	1/16/2025	NON-COMPETING CONTINUATION	$496,237
2025	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	001	4	3/3/2025	NON-COMPETING CONTINUATION	-$496,236
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = $3,341,554 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	002	4	7/24/2024	NON-COMPETING CONTINUATION	$3,341,554
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	000	3	11/2/2023	NON-COMPETING CONTINUATION	$0
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	001	3	12/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,341,554

Issue Date FY: 2023 ( Subtotal = $3,386,327 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	001	3	7/21/2023	NON-COMPETING CONTINUATION	$3,386,327
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	000	2	6/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,386,327

Issue Date FY: 2022 ( Subtotal = $4,377,865 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	002	2	8/3/2022	NON-COMPETING CONTINUATION	$3,403,105
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	001	1	6/9/2022	SUPPLEMENT FOR EXPANSION	$974,760
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	000	1	1/18/2022	NEW	$0
														Subtotal = $4,377,865

Issue Date FY: 2021 ( Subtotal = $2,999,998 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Child Health and Human Development Extramural Research	000	1	9/10/2021	NEW	$2,999,998
														Subtotal = $2,999,998

Grand Total All Awards = $14,105,745

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The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)

Award Number: P30HD106451

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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