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OHSU Knight Cancer Institute

Award Number: P30CA069533
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/1997
PERIOD OF PERFORMANCE END DATE: 06/30/2027

Group Awards By:

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OHSU Knight Cancer Institute - PROJECT SUMMARY: Director’s Overview and Essential Characteristics Brian Druker, M.D., Center Director The Knight Cancer Institute (KCI) at Oregon Health & Science University (OHSU) in Portland, Oregon, is the only NCI-designated comprehensive cancer center in our catchment area, the state of Oregon. Our goal is to leverage our unique strengths into treatment, early detection, and prevention strategies to improve patient outcomes. The KCI has 191 members belonging to four scientific programs (Cancer Biology, Translational Oncology, Quantitative Oncology, and Cancer Prevention and Control) and using six Shared Resources. In the past reporting period, we developed and are implementing a comprehensive strategic plan which defines three focus areas for our center: Culture of Inclusion and Innovation, Precision Oncology, and Precision Early Detection. We have defined a comprehensive Diversity Action Plan to align with OHSU's efforts to be an anti- racist institution and drive our efforts to ensure a Culture of Inclusion and Innovation within the KCI. Using our strategic plan as a compass, we recruited 56 investigators, including 12 senior leaders. We completed the design and construction of three new buildings, which allowed for the consolidation of our research and clinical care. We restructured our administration and advisory committees to ensure our members' engagement in the effective implementation of the strategic plan. These efforts have led to substantial increases in CCSG metrics, including NCI funding, intra- and inter-programmatic interactions, collaborative grants, and investigator-initiated trials. Thus, our current 191 KCI members are supported by $61.6 million in extramural funding, $26.9 million from the NCI. In the current funding period, members published 2,265 cancer-focused, peer-reviewed publications, of which 26% were intra-programmatic, 20% inter-programmatic, and 63% externally collaborative. In 2019, the last full year before the pandemic, 556 patients were enrolled on interventional treatment trials, representing 11% of our 5,065 new analytic cases. We continue our leadership in precision oncology (implementing sophisticated clinical trials based on comprehensive tumor analytics) and in advancing understanding of tumor biology, the immune microenvironment, and immunotherapeutics. We have provided leadership in numerous collaborative NCI projects and were selected to lead a Biden Cancer Moonshot grant, Evaluation of Population Based Testing for HBOC and Lynch Syndromes. We have refined and improved screening guidelines for multiple cancers, contributed to exercise guidelines for cancer survivors, made substantial investments in Community Outreach and Engagement, and invested in the education and training of the next-generation cancer workforce. Together, these achievements have accelerated progress towards driving scientific discoveries in precision oncology and precision early detection through our culture of inclusion and innovation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	27	1/26/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $3,197,535 )
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	003	27	8/28/2025	SUPPLEMENT FOR EXPANSION	$150,000
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	27	7/11/2025	NON-COMPETING CONTINUATION	$2,891,535
2025	2025	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	004	27	9/4/2025	SUPPLEMENT FOR EXPANSION	$156,000
2025	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	26	11/25/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	001	26	5/5/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,197,535

Issue Date FY: 2024 ( Subtotal = $3,083,153 )
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	003	26	8/21/2024	SUPPLEMENT FOR EXPANSION	$191,618
2024	2024	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	26	8/15/2024	NON-COMPETING CONTINUATION	$2,891,535
2024	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	25	10/25/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	001	25	4/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,083,153

Issue Date FY: 2023 ( Subtotal = $3,382,903 )
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	006	25	9/18/2023	SUPPLEMENT FOR EXPANSION	$299,750
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	004	25	7/19/2023	NON-COMPETING CONTINUATION	$2,891,535
2023	2023	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	005	25	7/21/2023	SUPPLEMENT FOR EXPANSION	$191,618
2023	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	24	5/12/2023	COMPETING CONTINUATION	$561,142
2023	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	003	23	5/12/2023	SUPPLEMENT FOR EXPANSION	-$115,000
2023	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	001	23	5/12/2023	SUPPLEMENT FOR EXPANSION	-$60,000
2023	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	23	5/12/2023	NON-COMPETING CONTINUATION	-$386,142
														Subtotal = $3,382,903

Issue Date FY: 2022 ( Subtotal = $3,198,153 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	24	5/26/2022	COMPETING CONTINUATION	$2,891,535
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	001	24	7/1/2022	SUPPLEMENT FOR EXPANSION	$115,000
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	24	8/23/2022	SUPPLEMENT FOR EXPANSION	$191,618
														Subtotal = $3,198,153

Issue Date FY: 2021 ( Subtotal = $2,884,999 )
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	003	23	7/16/2021	SUPPLEMENT FOR EXPANSION	$249,999
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	006	23	9/24/2021	SUPPLEMENT FOR EXPANSION	$150,000
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	23	7/1/2021	NON-COMPETING CONTINUATION	$2,310,000
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	004	23	7/17/2021	SUPPLEMENT FOR EXPANSION	$60,000
2021	2021	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	005	23	9/14/2021	SUPPLEMENT FOR EXPANSION	$115,000
2021	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	001	22	11/18/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	22	11/13/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,884,999

Issue Date FY: 2020 ( Subtotal = $3,688,636 )
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	22	6/17/2020	SUPPLEMENT FOR EXPANSION	$115,000
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	005	22	8/28/2020	SUPPLEMENT FOR EXPANSION	$499,758
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	22	6/10/2020	NON-COMPETING CONTINUATION	$2,310,000
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	007	22	9/9/2020	SUPPLEMENT FOR EXPANSION	$149,879
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	008	22	9/18/2020	SUPPLEMENT FOR EXPANSION	$150,000
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	006	22	9/1/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	003	22	8/17/2020	SUPPLEMENT FOR EXPANSION	$154,000
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	004	22	8/24/2020	SUPPLEMENT FOR EXPANSION	$249,999
2020	2020	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	001	22	6/16/2020	SUPPLEMENT FOR EXPANSION	$60,000
														Subtotal = $3,688,636

Issue Date FY: 2019 ( Subtotal = $2,934,082 )
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	003	21	7/19/2019	SUPPLEMENT FOR EXPANSION	$115,000
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	21	7/12/2019	SUPPLEMENT FOR EXPANSION	$249,458
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	004	21	9/3/2019	SUPPLEMENT FOR EXPANSION	$199,624
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	002	21	7/16/2019	SUPPLEMENT FOR EXPANSION	$60,000
2019	2019	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Cancer Centers Support Grants	000	21	6/28/2019	NON-COMPETING CONTINUATION	$2,310,000
														Subtotal = $2,934,082

Issue Date FY: 2018 ( Subtotal = $2,908,431 ) (Continued on the next page)
Grand Total All Awards = $56,820,168

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OHSU Knight Cancer Institute

Award Number: P30CA069533

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/1997

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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