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Early Career Cancer Clinical Investigator Award for Fiscal Year (FY) 2024

Award Number: P30CA060553
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/1997
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Early Career Cancer Clinical Investigator Award for Fiscal Year (FY) 2024 - Project Summary There are over 1.1 million people with HIV (PWH) in the United States, and nearly one-half (47%) are 50 or older. Even in the era of modern anti-retroviral therapy (ART) PWH are increasingly developing chronic co-morbid conditions associated with aging, including a variety of HIV-associated malignancies. The incidence of and mortality due to many HIV-associated cancers is exacerbated among PWH compared to HIV negative individuals. The etiology driving these findings is complicated but is thought to be due to lifestyle factors (e.g., smoking) and to pathophysiologic processes attributable to HIV. In addition to HIV-related inflammation, poor social determinants of health (SDoH) also contribute to higher levels of inflammation.13-15 SDoH include “the conditions in which people are born, grow, work, and live, and the wider set of forces and systems shaping the conditions of daily life.” SDoH have multiple domains (e.g., housing, primary care provider access, transportation, food security, medication affordability, substance use treatment, access to mental healthcare). In addition to these “conventional” domains, another key domain for socially minoritized populations is stigma as a fundamental SDoH. Indeed, systematic minoritization of socially stigmatized groups overarchingly shapes outcomes in other SDoH domains in these populations. These effects are often amplified among multiply minoritized populations. HIV disproportionately affects the health of many multiply minoritized groups, such as Black and Hispanic sexual minority men, transgender women of color, and Black cisgender women, among others. Studies indicate these multiply minoritized PWH populations are also often most likely to be impacted by HIV-associated cancers. These studies have largely focused on behavioral and/or clinical risk factors for malignancies without adequately addressing SDoH. Studies investigating how SDoH associate with disparities in the screening, diagnosis, treatment and outcomes of HIV-related malignancies among diverse – and especially multiply minoritized – PWH are therefore urgently needed. Our Chicago-based team thus proposes to accomplish the following Specific Aims: Specific Aim 1: Develop harmonized electronic medical record (EMR) algorithms to identify SDoH, demographic variables, and HIV care cascade outcomes as well as screening, diagnosis, and morbidity/mortality outcomes of HIV-associated malignancies of diverse PWH at UC and NM. Specific Aim 2: Investigate associations between SDoH and the screening, diagnosis, and morbidity/mortality outcomes of HIV-associated cancers and HIV care cascade outcomes among diverse PWH at UC and NM. The proposed project aligns with the highest impact NIH HIV/AIDS Research priorities. Its successful accomplishment will solidify collaborations in our interdisciplinary team to support a future R01 application in response to RFA-CA-22-056, “Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer.”


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $6,340,668 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	30	9/10/2024	SUPPLEMENT FOR EXPANSION	$59,992
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	003	30	8/23/2024	NON-COMPETING CONTINUATION	$6,280,676
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	29	11/28/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	29	6/26/2024	EXTENSION WITH OR WITHOUT FUNDS	$849,219
2024	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	28	6/26/2024	NON-COMPETING CONTINUATION	-$849,219
														Subtotal = $6,340,668

Issue Date FY: 2023 ( Subtotal = $6,526,763 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	29	8/30/2023	EXTENSION WITH OR WITHOUT FUNDS	$6,280,676
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	003	29	9/6/2023	SUPPLEMENT FOR EXPANSION	$247,704
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	28	1/2/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Detection and Diagnosis Research	001	25	5/11/2023	SUPPLEMENT FOR EXPANSION	-$1,617
														Subtotal = $6,526,763

Issue Date FY: 2022 ( Subtotal = $6,389,205 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	28	9/22/2022	SUPPLEMENT FOR EXPANSION	$108,535
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	28	7/20/2022	NON-COMPETING CONTINUATION	$6,280,670
														Subtotal = $6,389,205

Issue Date FY: 2021 ( Subtotal = $6,707,918 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	27	9/24/2021	SUPPLEMENT FOR EXPANSION	$302,248
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	003	27	8/10/2021	SUPPLEMENT FOR EXPANSION	$125,000
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	27	7/30/2021	NON-COMPETING CONTINUATION	$6,280,670
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Detection and Diagnosis Research	001	25	7/2/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Detection and Diagnosis Research	000	25	12/28/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $6,707,918

Issue Date FY: 2020 ( Subtotal = $7,590,293 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	26	9/10/2020	SUPPLEMENT FOR EXPANSION	$191,000
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	003	26	8/26/2020	SUPPLEMENT FOR EXPANSION	$298,623
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	26	8/27/2020	SUPPLEMENT FOR EXPANSION	$150,000
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	005	26	8/28/2020	SUPPLEMENT FOR EXPANSION	$150,000
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	26	8/25/2020	SUPPLEMENT FOR EXPANSION	$125,000
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	26	7/31/2020	NON-COMPETING CONTINUATION	$6,280,670
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Detection and Diagnosis Research	000	25	7/9/2020	SUPPLEMENT FOR EXPANSION	$395,000
														Subtotal = $7,590,293

Issue Date FY: 2019 ( Subtotal = $7,075,138 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	25	7/26/2019	SUPPLEMENT FOR EXPANSION	$250,000
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	005	25	7/30/2019	SUPPLEMENT FOR EXPANSION	$244,589
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	006	25	8/1/2019	SUPPLEMENT FOR EXPANSION	$99,879
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	25	7/29/2019	SUPPLEMENT FOR EXPANSION	$200,000
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	007	25	8/31/2019	NON-COMPETING CONTINUATION	$0
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	25	7/24/2019	NON-COMPETING CONTINUATION	$6,280,670
2019	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	24	1/10/2019	COMPETING CONTINUATION	$54,795
2019	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	23	1/10/2019	SUPPLEMENT FOR EXPANSION	-$54,795
														Subtotal = $7,075,138

Issue Date FY: 2018 ( Subtotal = $7,174,721 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	003	24	9/6/2018	SUPPLEMENT FOR EXPANSION	$246,169
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	005	24	9/25/2018	SUPPLEMENT FOR EXPANSION	$58,383
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	24	8/10/2018	COMPETING CONTINUATION	$6,295,169
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	24	9/14/2018	COMPETING CONTINUATION	$125,000
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	24	9/5/2018	SUPPLEMENT FOR EXPANSION	$200,000
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	24	8/24/2018	SUPPLEMENT FOR EXPANSION	$250,000
														Subtotal = $7,174,721

Issue Date FY: 2017 ( Subtotal = $5,207,300 ) (Continued on the next page)
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	008	23	8/30/2017	SUPPLEMENT FOR EXPANSION	$79,482
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	005	23	8/17/2017	NON-COMPETING CONTINUATION	$4,865,652
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	007	23	8/29/2017	SUPPLEMENT FOR EXPANSION	$204,369
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	006	23	8/28/2017	SUPPLEMENT FOR EXPANSION	$57,797
2017	2016	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	22	3/7/2017	EXTENSION WITH OR WITHOUT FUNDS	$3,586
Grand Total All Awards = $137,956,388

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Early Career Cancer Clinical Investigator Award for Fiscal Year (FY) 2024

Award Number: P30CA060553

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/1997

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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