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Addressing liver cancer health disparities among the South Texas Hispanic population residing in three persistent poverty counties using the STOP-HCC-HCV program as a framework

Award Number: P30CA054174
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract In 2017, Texas had the highest incidence of liver cancer in the United States and ranked second in liver cancer-associated mortality and the highest incidence rates occur in South Texas. Between 2001-2015, Texas had an average annual increase in liver cancer incidence of 3.9%, the national average was 3.8% per year for the same period. The population in South Texas is 70% Hispanic, 87% of whom identify as Mexican Americans. The South Texas Hispanic population experiences socioeconomic and healthcare disparities, leading to disproportionately higher rates of infectious disease-related cancer, including liver cancer. Between 2012-2017, the liver cancer incidence and mortality rate were higher among the Hispanic population than non-Hispanic whites in Texas. Additionally, Mexican Americans have a seven-fold all-cause mortality due to chronic HCV- associated disease compared to non-Hispanic whites and non-Hispanic blacks. Chronic HCV infection is a major risk factor for liver cancer. Our long-term goal is that by addressing chronic HCV infection through secondary prevention measures, we can assuage the liver cancer disparity in South Texas Hispanics. To achieve this goal, this study proposes two specific aims: (1) use Replicate Effective Programs (REP) to implement the evidence-based STOP-HCC-HCV program in two clinic systems primarily serving low-income, underserved Hispanic communities in three South Texas persistent poverty counties; (2) evaluate the effect of the STOP-HCC-HCV evidence-based program through empirical analysis of patient use outcomes and stakeholder feedback. The counties selected for this proposal are Hidalgo, Starr, and Cameron Counties, located in South Texas and designated as a Persistent Poverty Area, Health Professional Shortage Area, and Medically Underserved Area. There is a tendency for the public health system in persistent poverty areas to be chronically neglected. This proposed intervention will provide sustainable infrastructure to two community clinics using teleconsultations, tele-mentoring, making improvements to workflow and navigation, providing educational resources, and a technical evaluation to improve the HCV screening, treatment, and cure rates. The STOP- HCC-HCV program significantly increased the proportion of South Texas baby boomers screened and treated for chronic HCV; by tailoring this program for use in novel populations, we can strengthen the primary prevention of liver cancer through secondary prevention of HCV and contribute to the national strategic goal of eliminating HCV. Additionally, the data collected from this program will inform the development of future preventive strategies directly relevant for the South Texas Hispanic population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $2,191,700 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	28	7/19/2023	NON-COMPETING CONTINUATION	$2,191,700
2023	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	27	1/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,191,700

Issue Date FY: 2022 ( Subtotal = $2,191,700 )
2022	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	27	6/27/2022	NON-COMPETING CONTINUATION	$2,191,700
														Subtotal = $2,191,700

Issue Date FY: 2021 ( Subtotal = $2,391,659 )
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	010	26	9/23/2021	SUPPLEMENT FOR EXPANSION	$199,959
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	009	26	8/1/2021	NON-COMPETING CONTINUATION	$2,191,700
2021	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	008	25	7/13/2021	COMPETING CONTINUATION	$145,150
2021	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	005	25	6/24/2021	COMPETING CONTINUATION	-$146,650
2021	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	002	25	5/20/2021	COMPETING CONTINUATION	$146,650
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	004	24	6/24/2021	SUPPLEMENT FOR EXPANSION	$60,000
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	007	24	7/13/2021	SUPPLEMENT FOR EXPANSION	-$60,000
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	003	24	6/24/2021	SUPPLEMENT FOR EXPANSION	$86,650
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	24	5/20/2021	SUPPLEMENT FOR EXPANSION	-$86,650
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	24	5/20/2021	SUPPLEMENT FOR EXPANSION	-$60,000
2021	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	006	24	7/13/2021	SUPPLEMENT FOR EXPANSION	-$85,150
														Subtotal = $2,391,659

Issue Date FY: 2020 ( Subtotal = $2,657,763 )
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Treatment Research	002	25	9/18/2020	SUPPLEMENT FOR EXPANSION	$167,497
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Treatment Research	001	25	9/3/2020	SUPPLEMENT FOR EXPANSION	$299,744
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	25	8/13/2020	COMPETING CONTINUATION	$2,190,522
														Subtotal = $2,657,763

Issue Date FY: 2019 ( Subtotal = $2,195,000 )
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	002	24	9/13/2019	SUPPLEMENT FOR EXPANSION	-$539
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	24	9/12/2019	SUPPLEMENT FOR EXPANSION	$60,539
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	24	6/5/2019	SUPPLEMENT FOR EXPANSION	$2,135,000
														Subtotal = $2,195,000

Issue Date FY: 2018 ( Subtotal = $2,335,753 )
2018	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	002	24	8/23/2018	SUPPLEMENT FOR EXPANSION	$59,998
2018	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	24	8/1/2018	SUPPLEMENT FOR EXPANSION	$112,755
2018	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	003	24	9/5/2018	SUPPLEMENT FOR EXPANSION	$70,000
2018	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	24	7/17/2018	NON-COMPETING CONTINUATION	$2,093,000
														Subtotal = $2,335,753

Issue Date FY: 2017 ( Subtotal = $2,325,981 )
2017	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	23	8/18/2017	SUPPLEMENT FOR EXPANSION	$120,226
2017	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	002	23	8/21/2017	SUPPLEMENT FOR EXPANSION	$112,755
2017	2017	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	23	7/17/2017	NON-COMPETING CONTINUATION	$2,093,000
														Subtotal = $2,325,981

Issue Date FY: 2016 ( Subtotal = $2,326,896 )
2016	2016	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	22	8/18/2016	NON-COMPETING CONTINUATION	$2,093,000
2016	2016	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	22	8/19/2016	SUPPLEMENT FOR EXPANSION	$121,141
2016	2016	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	002	22	8/20/2016	SUPPLEMENT FOR EXPANSION	$112,755
														Subtotal = $2,326,896

Issue Date FY: 2015 ( Subtotal = $1,921,141 )
2015	2015	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	21	8/28/2015	SUPPLEMENT FOR EXPANSION	$121,141
2015	2015	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	21	7/29/2015	NON-COMPETING CONTINUATION	$1,800,000
														Subtotal = $1,921,141

Issue Date FY: 2014 ( Subtotal = $1,875,000 )
2014	2014	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	20	9/16/2014	COMPETING CONTINUATION	$1,800,000
2014	2014	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	20	9/23/2014	SUPPLEMENT FOR EXPANSION	$75,000
														Subtotal = $1,875,000

Issue Date FY: 2013 ( Subtotal = $725,628 )
2013	2013	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	000	19	8/8/2013	SUPPLEMENT FOR EXPANSION	$650,628
2013	2013	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Cause and Prevention Research	002	19	8/27/2013	SUPPLEMENT FOR EXPANSION	$75,000
2013	2011	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78284	BEXAR	USA	Cancer Centers Support Grants	001	19	8/13/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $725,628

Issue Date FY: 2012 ( Subtotal = $1,349,633 ) (Continued on the next page)
2012	2012	UNIVERSITY OF TEXAS HEALTH SCIENCE CTR AT SAN ANTONIO	7703 FLOYD CURL DRIVE	SAN ANTONIO	TX	78229	BEXAR	USA	Cancer Centers Support Grants	001	19	8/20/2012	SUPPLEMENT FOR EXPANSION	-$668
Grand Total All Awards = $54,293,663

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Addressing liver cancer health disparities among the South Texas Hispanic population residing in three persistent poverty counties using the STOP-HCC-HCV program as a framework

Award Number: P30CA054174

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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