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Heterogeneity of tumor transcriptomics in underrepresented populations

Award Number: P30CA042014
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Heterogeneity of tumor transcriptomics in underrepresented populations - ABSTRACT In 2021, Huntsman Cancer Institute (HCI) formalized our long-standing service to the entire 5-state Mountain West (MW). Three of the five states: Idaho, Nevada, and Utah, all ranked among the top five fastest growing states in the 2020 U.S. Census. At the same time, the area we serve is notable for its vast frontier areas. Of the 169 counties in the Mountain West, 104 are frontier (< 7 people per square mile), covering 74% of the landmass and an additional 54 classify as rural (< 100 people per square mile). Combined, the frontier and rural counties account for 97% of the landmass. Over 10% of the Mountain West population lives in frontier counties and over 40% lives in frontier and rural counties combined. These populations experience disparities due primarily to distance to care. HCI is committed to overcome distance as a disparity by ensuring frontier and rural patients have equal access to excellent care and prevention services, regardless of location. Cervical cancer incidence rates are higher in rural Utah (compared to urban Utah) and 5-year relative survival rates are lower among rural cervical cancer patients than among urban patients. Furthermore, Utah ranks as one of the lowest states in the nation for cervical cancer screening with rural communities demonstrating the lowest rates. This study pilot tests a mail-delivered HPV self-collection program for rural Utah women (N=900). This study aims to develop a rural community health center delivered home-based human papillomavirus (HPV) self- collection outreach program for women overdue for cervical cancer screening and a follow-up program for women with HPV screen-positive results. Specifically, we will launch an HPV self-collection program to women overdue for cervical cancer screening, revise related illustrated video- and print-delivered instructions in English and Spanish on how to complete the test, and develop an effective follow-up approach for HPV screen-positive patients. Through surveys, we will assess barriers for why patients do not return the HPV self- collection kits and why HPV screen-positive women do not receive follow-up care. We will also assess the organizational, provider, and clinic staff level factors at rural community health centers that facilitate the implementation, assessment and follow-up for the pilot HPV self-collection program. These clinic-level assessments will be completed through work-flow analyses, surveys, and semi-structured interviews. Findings from this study will be used to develop a mail-delivered HPV self-collection protocol for rural community health centers that can be adapted and replicated in other rural community health center settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $4,777,590 )
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	007	35	9/18/2024	SUPPLEMENT FOR EXPANSION	$192,489
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	009	35	9/20/2024	SUPPLEMENT FOR EXPANSION	$100,000
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	005	35	6/5/2024	SUPPLEMENT FOR EXPANSION	$190,613
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	008	35	9/19/2024	SUPPLEMENT FOR EXPANSION	$99,983
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	006	35	9/17/2024	SUPPLEMENT FOR EXPANSION	$200,000
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	004	35	6/4/2024	NON-COMPETING CONTINUATION	$4,199,958
2024	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	002	34	10/13/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	001	34	10/13/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	34	10/31/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2019	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	000	30	10/1/2023	SUPPLEMENT FOR EXPANSION	-$205,453
														Subtotal = $4,777,590

Issue Date FY: 2023 ( Subtotal = $5,880,983 )
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	008	34	9/21/2023	SUPPLEMENT FOR EXPANSION	$231,000
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	002	34	5/17/2023	NON-COMPETING CONTINUATION	$4,586,542
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	004	34	9/18/2023	SUPPLEMENT FOR EXPANSION	$124,997
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	003	34	9/15/2023	SUPPLEMENT FOR EXPANSION	$215,470
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	006	34	9/20/2023	SUPPLEMENT FOR EXPANSION	$307,975
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	007	34	9/20/2023	SUPPLEMENT FOR EXPANSION	$200,000
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	005	34	9/19/2023	SUPPLEMENT FOR EXPANSION	$214,999
2023	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	001	33	11/29/2022	SUPPLEMENT FOR EXPANSION	$0
2023	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	000	33	11/2/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $5,880,983

Issue Date FY: 2022 ( Subtotal = $5,327,342 )
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	010	33	5/3/2022	SUPPLEMENT FOR EXPANSION	$114,840
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	007	33	4/25/2022	NON-COMPETING CONTINUATION	-$519,611
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	008	33	4/29/2022	SUPPLEMENT FOR EXPANSION	$154,772
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	011	33	5/25/2022	SUPPLEMENT FOR EXPANSION	$190,622
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	013	33	6/8/2022	NON-COMPETING CONTINUATION	$217,291
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	006	33	4/19/2022	NON-COMPETING CONTINUATION	$4,719,569
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	009	33	5/2/2022	SUPPLEMENT FOR EXPANSION	$249,999
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	014	33	9/9/2022	SUPPLEMENT FOR EXPANSION	$199,860
2022	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	012	32	5/26/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	000	32	10/22/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	001	31	11/4/2021	COMPETING CONTINUATION	$279,497
2022	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	004	31	11/4/2021	COMPETING CONTINUATION	$43,466
2022	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	002	30	11/4/2021	SUPPLEMENT FOR EXPANSION	-$79,508
2022	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	005	30	11/4/2021	SUPPLEMENT FOR EXPANSION	-$43,466
2022	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	003	30	11/4/2021	SUPPLEMENT FOR EXPANSION	-$199,989
														Subtotal = $5,327,342

Issue Date FY: 2021 ( Subtotal = $4,912,287 ) (Continued on the next page)
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	005	32	4/9/2021	SUPPLEMENT FOR EXPANSION	$60,000
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	013	32	9/23/2021	SUPPLEMENT FOR EXPANSION	$149,999
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	006	32	4/12/2021	SUPPLEMENT FOR EXPANSION	$137,331
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	011	32	9/21/2021	SUPPLEMENT FOR EXPANSION	$249,999
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	012	32	9/22/2021	SUPPLEMENT FOR EXPANSION	$115,000
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	010	32	8/31/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	004	32	4/8/2021	NON-COMPETING CONTINUATION	$4,199,958
2021	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	007	31	5/18/2021	COMPETING CONTINUATION	-$279,497
2021	2020	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	000	31	12/2/2020	COMPETING CONTINUATION	$322,962
2021	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	008	30	5/18/2021	SUPPLEMENT FOR EXPANSION	$79,508
2021	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	009	30	5/18/2021	SUPPLEMENT FOR EXPANSION	$199,989
2021	2019	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cancer Centers Support Grants	003	30	12/2/2020	SUPPLEMENT FOR EXPANSION	-$199,989
Grand Total All Awards = $61,761,370

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Heterogeneity of tumor transcriptomics in underrepresented populations

Award Number: P30CA042014

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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