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Cancer Center Support Grant

Award Number: P30CA023108
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/1997
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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Cancer Center Support Grant - Project Summary/Abstract: Overall The Norris Cotton Cancer Center (NCCC) is responsible for overseeing all cancer-related academic and clinical activities across the entirety of Dartmouth College and the Dartmouth-Hitchcock (D-H) health system, as evidenced by 123 Members spanning 4 Schools and 24 Departments and NCCC-initiated research infrastructure adopted campus-wide. In the current application, we summarize research accomplishments and document fulfillment of the NCI’s Six Essential Characteristics for NCI-Designated Centers. The mission of NCCC is to accelerate trans-disciplinary research to prevent and cure cancer, enhance survivorship, and promote health equity, evident in significant funded patient-centric population science and diversity-focused engagement of trainees across the education continuum. Reflecting deep integration within our host institutions, NCCC is comprised of four truly trans-disciplinary research programs, reflecting active NCCC Planning & Evaluation: Immunology and Cancer Immunotherapy (ICI); Translational Engineering in Cancer (TEC); Cancer Biology and Therapeutics (CBT); and Cancer Population Sciences (CPS). Included in our research portfolio are groundbreaking scientific initiatives in cancer immunology, cancer engineering, biological mechanisms, experimental therapeutics, molecular epidemiology, health care delivery science and cancer prevention and control, with an enhanced emphasis on translating research discoveries to hard-to-reach populations, especially those within our rural two-state catchment area of New Hampshire and Vermont. NCCC continues to be defined by its high impact scientific publications and the frequency with which they are enabled by Cancer Center support of trans-disciplinary research, as evidenced by inter- (31%) and intra-(17%) co- authorships, cancer themes in IDeA-funded program projects, and access to NCCC Shared Resources that include several (e.g., Pathology, Trace Elements, Genomics) relied upon widely by other NCI designated centers. Consistent with our commitment to both high quality science and the successful translation of research discoveries to the clinic, the past five years have witnessed an 18% increase in our NIH-funded research portfolio, including a >7:1 return on Developmental Funds, and a 62% increase in clinical trials accrual, including funding as an NCTN lead participation site. Depth of Leadership was evidenced by accomplishments during a recent Director transition. Shortly following the September 2017 arrival of Dr. Steven Leach as Center Director, NCCC embarked upon a new 2018 Strategic Plan, which identified accelerating translational and trans-disciplinary research as our single highest overarching strategic priority. Emanating from this plan and enabled by a dramatic increase in investment from our parent institutions, in this application we further document the launch of multiple new initiatives in faculty recruitment (8 completed in 2017-2018, 3 active, and 2 pending), faculty research support, education and community outreach, serving to propel a comprehensive NCCC into its fifth decade of NCI designation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,139,306 )
2025	2025	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	003	46	5/19/2025	COMPETING CONTINUATION	$2,669,049
2025	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	001	45	4/3/2025	SUPPLEMENT FOR EXPANSION	-$48,413
2025	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	000	45	4/3/2025	NON-COMPETING CONTINUATION	-$481,330
2025	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Detection and Diagnosis Research	002	41	4/8/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,139,306

Issue Date FY: 2024 ( Subtotal = $3,388,494 )
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	001	45	7/29/2024	SUPPLEMENT FOR EXPANSION	$209,673
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	000	45	3/1/2024	NON-COMPETING CONTINUATION	$2,770,940
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	003	45	8/30/2024	SUPPLEMENT FOR EXPANSION	$99,999
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	002	45	8/28/2024	NON-COMPETING CONTINUATION	$307,882
														Subtotal = $3,388,494

Issue Date FY: 2023 ( Subtotal = $3,178,822 )
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	002	44	9/18/2023	SUPPLEMENT FOR EXPANSION	$100,000
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	000	44	12/1/2022	NON-COMPETING CONTINUATION	$3,078,822
2023	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Detection and Diagnosis Research	001	41	12/7/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,178,822

Issue Date FY: 2022 ( Subtotal = $3,332,697 )
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	001	43	2/18/2022	SUPPLEMENT FOR EXPANSION	$115,000
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Detection and Diagnosis Research	003	41	9/13/2022	SUPPLEMENT FOR EXPANSION	$63,875
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	002	43	9/9/2022	SUPPLEMENT FOR EXPANSION	$75,000
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	000	43	1/24/2022	NON-COMPETING CONTINUATION	$3,078,822
														Subtotal = $3,332,697

Issue Date FY: 2021 ( Subtotal = $3,451,719 )
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	004	42	8/31/2021	SUPPLEMENT FOR EXPANSION	$171,781
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	005	42	9/9/2021	SUPPLEMENT FOR EXPANSION	$115,000
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	002	42	12/1/2020	NON-COMPETING CONTINUATION	$3,078,822
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	006	42	9/20/2021	SUPPLEMENT FOR EXPANSION	$149,991
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Detection and Diagnosis Research	001	41	11/18/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	000	41	11/6/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Detection and Diagnosis Research	003	41	4/28/2021	SUPPLEMENT FOR EXPANSION	-$63,875
														Subtotal = $3,451,719

Issue Date FY: 2020 ( Subtotal = $5,539,304 )
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	020	41	9/11/2020	SUPPLEMENT FOR EXPANSION	$199,997
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	019	41	9/3/2020	SUPPLEMENT FOR EXPANSION	$199,998
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	004	41	6/4/2020	SUPPLEMENT FOR EXPANSION	$169,239
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	016	41	7/13/2020	SUPPLEMENT FOR EXPANSION	$100,000
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Detection and Diagnosis Research	015	41	7/10/2020	SUPPLEMENT FOR EXPANSION	$328,000
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	005	41	6/8/2020	SUPPLEMENT FOR EXPANSION	$204,000
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	017	41	7/14/2020	SUPPLEMENT FOR EXPANSION	$820,000
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	002	41	5/21/2020	SUPPLEMENT FOR EXPANSION	$83,332
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	41	5/20/2020	SUPPLEMENT FOR EXPANSION	$137,804
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	013	41	6/22/2020	COMPETING CONTINUATION	$951,461
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	000	41	5/15/2020	COMPETING CONTINUATION	$3,106,067
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	018	41	8/31/2020	SUPPLEMENT FOR EXPANSION	$99,999
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	014	41	7/8/2020	SUPPLEMENT FOR EXPANSION	$31,668
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	003	41	5/22/2020	SUPPLEMENT FOR EXPANSION	$59,200
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	008	40	6/22/2020	SUPPLEMENT FOR EXPANSION	-$132,519
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	009	40	6/22/2020	SUPPLEMENT FOR EXPANSION	-$59,200
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	006	40	6/22/2020	NON-COMPETING CONTINUATION	-$206,661
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	011	40	6/22/2020	SUPPLEMENT FOR EXPANSION	-$50,000
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	012	40	6/22/2020	SUPPLEMENT FOR EXPANSION	-$205,908
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Cancer Centers Support Grants	010	40	6/22/2020	SUPPLEMENT FOR EXPANSION	-$83,332
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	007	40	6/22/2020	SUPPLEMENT FOR EXPANSION	-$213,841
														Subtotal = $5,539,304

Issue Date FY: 2019 ( Subtotal = $3,884,624 ) (Continued on the next page)
Grand Total All Awards = $86,381,828

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Cancer Center Support Grant

Award Number: P30CA023108

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/1997

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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