Saturday, April 20, 2024 4/20/2024

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Award Number: P30CA013330
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Abstract It is now well-established that COVID-19 in patients with cancer carries a higher morbidity and mortality, especially in amongst patients with hematologic malignancies1, 2. Effective vaccines have been developed and authorized by the FDA to combat this pandemic3-5. However, emerging data suggests that despite these vaccines inducing high levels of immunity in the general population, patients with hematologic malignancies have lower rates of seroconversion for the SARS-CoV-2 Spike antibody6-9. Indeed, our prior data had suggested excellent immunogenicity of the currently FDA authorized Covid-19 vaccines for most patients with a malignant diagnosis with exception of unique cohorts- patients with hematological malignancies and following highly immune suppressive therapies (SCT, CAR-T, anti-CD20). Our current study plans to address the efficacy of Covid-19 booster vaccinations amongst patients with a cancer diagnosis with a special focus on patients with undetectable or low anti-Spike IgG antibody levels. 250 patients with a diverse range of ethnicities, cancer diagnosis and prior cancer therapies will be enrolled in this study and the response to booster vaccinations will be assessed using standard anti-Spike IgG as well as investigational T cell and Virus Neutralization assays. In addition, in a second cohort we will define if a “mix and match” vaccination strategy might be more successful at achieving detectable immunity in patients with persistently negative/low antibody levels despite booster vaccinations. In this cohort, 100 patients will be accrued who by anti-spike IgG assays have not developed detectable or have low levels of humoral immunity. These patients will be randomized to receive an additional dose of an mRNA based vaccine (BNT162b2) versus an adenoviral vaccine (AdCov2.S).Both studies will assess safety and efficacy of these vaccination schemes and will provide long-term data with 24 months of follow up planned. These studies should provide critical information to best address proper protective strategies for uniquely vulnerable patient populations with a cancer diagnosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $4,087,971 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	001	51	9/7/2023	COMPETING CONTINUATION	$4,087,971
2023	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	50	10/19/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,087,971

Issue Date FY: 2022 ( Subtotal = $4,132,080 )
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	003	50	9/21/2022	SUPPLEMENT FOR EXPANSION	$249,999
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	008	50	9/27/2022	SUPPLEMENT FOR EXPANSION	$334,913
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	49	12/14/2021	SUPPLEMENT FOR EXPANSION	$431,130
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	007	50	9/27/2022	SUPPLEMENT FOR EXPANSION	$249,999
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	005	50	9/27/2022	SUPPLEMENT FOR EXPANSION	-$334,913
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	006	50	9/27/2022	SUPPLEMENT FOR EXPANSION	-$249,999
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	001	50	7/7/2022	NON-COMPETING CONTINUATION	$2,906,419
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	002	50	7/11/2022	SUPPLEMENT FOR EXPANSION	$209,619
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	004	50	9/22/2022	SUPPLEMENT FOR EXPANSION	$334,913
														Subtotal = $4,132,080

Issue Date FY: 2021 ( Subtotal = $3,404,805 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	007	49	6/25/2021	SUPPLEMENT FOR EXPANSION	$237,147
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	006	49	6/22/2021	NON-COMPETING CONTINUATION	$2,916,911
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	008	49	6/28/2021	SUPPLEMENT FOR EXPANSION	$250,747
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	004	48	12/23/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	003	48	12/22/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	009	48	9/17/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	002	48	12/21/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	48	11/17/2020	NON-COMPETING CONTINUATION	$0
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	005	48	12/28/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	001	48	12/16/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,404,805

Issue Date FY: 2020 ( Subtotal = $3,697,114 )
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	004	48	8/24/2020	SUPPLEMENT FOR EXPANSION	$250,373
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	002	48	8/4/2020	NON-COMPETING CONTINUATION	$2,916,911
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	007	48	9/18/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	005	48	9/3/2020	SUPPLEMENT FOR EXPANSION	$125,216
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Detection and Diagnosis Research	006	48	9/8/2020	SUPPLEMENT FOR EXPANSION	$167,791
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	003	48	8/21/2020	SUPPLEMENT FOR EXPANSION	$236,823
2020	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	47	11/26/2019	COMPETING CONTINUATION	$14,865
2020	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	001	46	11/26/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$14,865
														Subtotal = $3,697,114

Issue Date FY: 2019 ( Subtotal = $2,916,911 )
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	005	47	8/19/2019	COMPETING CONTINUATION	$2,916,911
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	003	45	4/29/2019	SUPPLEMENT FOR EXPANSION	-$432,248
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	001	45	2/13/2019	SUPPLEMENT FOR EXPANSION	-$1,854,986
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	004	46	4/29/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$432,248
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	002	46	2/13/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,854,986
2019	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	000	45	2/12/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,916,911

Issue Date FY: 2018 ( Subtotal = $3,646,138 )
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Centers Support Grants	000	45	7/18/2018	SUPPLEMENT FOR EXPANSION	$3,646,138
2018	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	001	45	8/1/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,646,138

Issue Date FY: 2017 ( Subtotal = $3,646,138 )
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cancer Cause and Prevention Research	000	45	7/3/2017	NON-COMPETING CONTINUATION	$3,646,138
														Subtotal = $3,646,138

Issue Date FY: 2016 ( Subtotal = $4,645,998 ) (Continued on the next page)
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Cause and Prevention Research	004	44	6/14/2016	NON-COMPETING CONTINUATION	$3,746,138
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Cause and Prevention Research	006	44	8/30/2016	SUPPLEMENT FOR EXPANSION	$199,989
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Centers Support Grants	007	44	8/31/2016	SUPPLEMENT FOR EXPANSION	$500,000
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Cancer Cause and Prevention Research	005	44	6/22/2016	SUPPLEMENT FOR EXPANSION	$199,871
Grand Total All Awards = $103,212,980

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Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Award Number: P30CA013330

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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