Thursday, November 21, 2024 11/21/2024

Cancer Center Support Grant

Award Number: P30CA008748
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary: Precision medicine and targeted therapy are emerging domains in cancer biology that aim to incorporate individual-level clinical, pathological and genomic profiles to tailor treatment strategies for cancer patients. Several precision oncology knowledge bases, like OncoKB, My Cancer Genome, have been established to democratize clinical decision-making by leveraging expert curation of biological and clinical significance of alterations using publicly available resources. These knowledge bases, while extremely powerful, have their limitations, including the scope of annotated genes and alterations, as well as identifying precise therapies for specific combinations of a patient's genomic and clinical profiles. In this proposal, we plan to develop new computational methodologies that will integrate (i) the broad range of implicit cancer knowledge accrued by Large Language Models (LLMs) with (ii) the explicit structured clinical, pathological, and genomic knowledge derived from cancer patients in the Memorial Sloan Kettering Cancer Center’s (MSKCC) Clinical Sequencing cohort and AACR Project GENIE cohort. This will further be reinforced by expert curation, with the aim to predict combinations of genomic alterations and clinical or pathological profiles that can be matched to a specific cancer therapy. The goal of this research is to develop computational models fundamentally anchored around knowledge graphs and LLMs to bridge the gap between clinical and functional risk factors of cancer and cancer therapeutics, and to inform and enhance personalized therapies. The first aim of this proposal is to develop a knowledge graph, MSK-CancerKG, based on patient-specific clinical, pathological, and genomic alteration information from more than 100,000 patients from the MSKCC Clinical Sequencing Cohort and the AACR GENIE Project cohort. This multi-relational knowledge graph will integrate a wide spectrum of clinical features associated with each patient, abstracted features from pathological reports corresponding to the patient-derived tumor samples, along with comprehensive characterization of genomic alterations and the implicated genes. The second aim will be geared towards the fine-tuning of pre-trained Large Language Models (LLMs) using the structured, detailed and more reliable cancer-specific knowledge from MSK- CancerKG. We will meticulously benchmark these fine-tuned models against 4 state-of-the art pre-trained language models, ultimately deriving an optimized combined predictive model, coined MSK-CancerLLM. The benchmarking step will include successful clinical, alteration and treatment prediction accuracy on held-out patient data. The third aim of the proposal will be to further fine-tune MSK-CancerLLM using clinical practice guidelines and feedback to model output from cancer domain experts. The resulting model will be integrated into an AI chatbot, called MSK-Assistant, to facilitate seamless integration and interaction between the backend model and a frontend chatbot interface. Like the ChatGPT application, this will allow the research community to query about cancer biology and personalized drug recommendations and therapeutic interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $13,458,241 )
2024	2024	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	58	3/12/2024	EXTENSION WITH OR WITHOUT FUNDS	$12,112,427
2024	2024	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	58	4/29/2024	EXTENSION WITH OR WITHOUT FUNDS	$1,345,814
														Subtotal = $13,458,241

Issue Date FY: 2023 ( Subtotal = $14,033,522 )
2023	2023	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVENUE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	004	57	9/8/2023	SUPPLEMENT FOR EXPANSION	$299,999
2023	2023	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	002	57	1/20/2023	NON-COMPETING CONTINUATION	$0
2023	2023	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	57	1/9/2023	NON-COMPETING CONTINUATION	$13,733,523
2023	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	003	56	1/23/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	56	1/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $14,033,522

Issue Date FY: 2022 ( Subtotal = $13,957,077 )
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	003	54	5/2/2022	SUPPLEMENT FOR EXPANSION	-$163,555
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	56	2/14/2022	NON-COMPETING CONTINUATION	$13,733,523
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	004	54	5/6/2022	SUPPLEMENT FOR EXPANSION	$163,555
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	56	2/16/2022	SUPPLEMENT FOR EXPANSION	$59,999
2022	2022	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	002	54	4/28/2022	SUPPLEMENT FOR EXPANSION	$163,555
														Subtotal = $13,957,077

Issue Date FY: 2021 ( Subtotal = $14,043,516 )
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	004	55	9/22/2021	SUPPLEMENT FOR EXPANSION	$213,550
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	003	55	5/31/2021	SUPPLEMENT FOR EXPANSION	$59,999
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	005	55	9/23/2021	SUPPLEMENT FOR EXPANSION	$199,999
2021	2021	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	55	12/16/2020	NON-COMPETING CONTINUATION	$13,733,523
2021	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Detection and Diagnosis Research	002	54	4/1/2021	SUPPLEMENT FOR EXPANSION	-$163,555
2021	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	54	11/17/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $14,043,516

Issue Date FY: 2020 ( Subtotal = $14,806,471 )
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	002	54	9/17/2020	SUPPLEMENT FOR EXPANSION	$149,284
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	005	54	9/22/2020	SUPPLEMENT FOR EXPANSION	$186,664
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Detection and Diagnosis Research	004	54	9/21/2020	SUPPLEMENT FOR EXPANSION	$177,000
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	54	1/13/2020	NON-COMPETING CONTINUATION	$13,733,523
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	54	2/5/2020	SUPPLEMENT FOR EXPANSION	$60,000
2020	2020	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Treatment Research	003	54	9/18/2020	SUPPLEMENT FOR EXPANSION	$500,000
														Subtotal = $14,806,471

Issue Date FY: 2019 ( Subtotal = $14,111,780 )
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	007	53	5/13/2019	SUPPLEMENT FOR EXPANSION	$94,527
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	008	53	5/24/2019	SUPPLEMENT FOR EXPANSION	$60,000
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	53	5/9/2019	SUPPLEMENT FOR EXPANSION	$255,120
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	53	1/31/2019	COMPETING CONTINUATION	$13,702,133
2019	2019	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	005	53	4/30/2019	COMPETING CONTINUATION	$848,841
2019	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	52	4/30/2019	SUPPLEMENT FOR EXPANSION	-$113,248
2019	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	001	52	4/30/2019	SUPPLEMENT FOR EXPANSION	-$62,875
2019	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	004	52	4/30/2019	SUPPLEMENT FOR EXPANSION	-$305,312
2019	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	52	4/30/2019	SUPPLEMENT FOR EXPANSION	-$367,406
														Subtotal = $14,111,780

Issue Date FY: 2018 ( Subtotal = $13,320,025 )
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	005	52	8/22/2018	SUPPLEMENT FOR EXPANSION	$113,248
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	52	2/15/2018	SUPPLEMENT FOR EXPANSION	$437,083
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	52	12/21/2017	NON-COMPETING CONTINUATION	$11,117,646
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	52	8/31/2018	SUPPLEMENT FOR EXPANSION	$305,312
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	004	52	5/24/2018	SUPPLEMENT FOR EXPANSION	$48,565
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	002	52	3/27/2018	SUPPLEMENT FOR EXPANSION	$62,875
2018	2018	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	003	52	5/23/2018	NON-COMPETING CONTINUATION	$1,235,296
														Subtotal = $13,320,025

Issue Date FY: 2017 ( Subtotal = $12,809,742 ) (Continued on the next page)
2017	2017	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	004	51	6/27/2017	SUPPLEMENT FOR EXPANSION	$12,574
2017	2017	SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH	1275 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Centers Support Grants	000	51	12/27/2016	NON-COMPETING CONTINUATION	$11,117,646
Grand Total All Awards = $318,681,922

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Cancer Center Support Grant

Award Number: P30CA008748

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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