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Regional Oncology Research Center (Heterogeneity)

Award Number: P30CA006973
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Regional Oncology Research Center (Heterogeneity) - PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-032. Black women have the highest breast cancer mortality rate and shortest overall survival among all racial/ethnic groups of women in the United States. Adverse social determinants of health (SDoH) (e.g., structural racism) are documented sources of racial disparities in breast cancer. However, research studies examining the mechanistic pathways of these associations and those examining within-group differences among Black women are lacking. This study seeks to overcome these limitations of current research by examining the extent to which SDoH measures are associated with inflammatory biomarkers among Black women. We will recruit a socio-demographically heterogeneous sample of Black breast cancer survivors from Maryland. Participants will provide survey data, blood samples, and qualitative data. Integrating these data, we will assess associations and generate new hypotheses about the influence of adverse SDoH on breast cancer among Black women. In Aim 1 of the study, we will examine associations between SDoH, patient-reported outcomes, and inflammation-related protein biomarkers in a sample of 100 socio-demographically diverse Black BC survivors. We will employ statistical and laboratory analyses to examine associations of SDoH measures and health-related quality of life with inflammatory biomarkers overall and explore stratifications by measures of individual socioeconomic position. In Aim 2 of the study, we will conduct eight focus groups with a subset of participants from Aim 1. Focus groups will be homogeneous by age group and area of residence to more comprehensively understand within-group lived experiences related to SDoH and breast cancer. We will integrate qualitative analyses with findings from Aim 1 using a mixed methods analytic approach. The study is strongly aligned with NOT-CA-24-032 and with the priorities of the parent grant (P30CA006973). Findings will provide insight into how social factors can impact inflammation and cancer outcomes in varied socio-demographic subgroups of Black women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	61	2/19/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $8,083,596 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	61	5/7/2024	NON-COMPETING CONTINUATION	$7,776,239
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	003	61	9/11/2024	SUPPLEMENT FOR EXPANSION	$207,357
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	002	61	9/10/2024	SUPPLEMENT FOR EXPANSION	$100,000
2024	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	60	10/16/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $8,083,596

Issue Date FY: 2023 ( Subtotal = $9,007,005 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	004	60	8/28/2023	SUPPLEMENT FOR EXPANSION	$249,785
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	002	59	3/21/2023	SUPPLEMENT FOR EXPANSION	$100,000
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	007	60	9/22/2023	SUPPLEMENT FOR EXPANSION	$480,981
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	005	60	9/19/2023	SUPPLEMENT FOR EXPANSION	$100,000
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	003	60	7/11/2023	NON-COMPETING CONTINUATION	$7,776,239
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	006	60	9/20/2023	SUPPLEMENT FOR EXPANSION	$300,000
2023	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	59	2/22/2023	COMPETING CONTINUATION	$264,849
2023	2021	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	58	2/22/2023	NON-COMPETING CONTINUATION	-$264,849
														Subtotal = $9,007,005

Issue Date FY: 2022 ( Subtotal = $7,877,577 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	002	59	7/1/2022	SUPPLEMENT FOR EXPANSION	$82,381
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	004	59	8/30/2022	COMPETING CONTINUATION	$51,029
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	005	59	9/1/2022	COMPETING CONTINUATION	-$51,029
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	006	59	9/2/2022	SUPPLEMENT FOR EXPANSION	$51,029
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	59	6/20/2022	COMPETING CONTINUATION	$7,776,239
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	003	59	7/4/2022	SUPPLEMENT FOR EXPANSION	-$32,072
2022	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	58	10/21/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $7,877,577

Issue Date FY: 2021 ( Subtotal = $7,720,833 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	004	58	4/12/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	003	58	4/9/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	005	58	9/24/2021	SUPPLEMENT FOR EXPANSION	$150,000
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	002	58	4/8/2021	NON-COMPETING CONTINUATION	$7,070,833
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	57	1/11/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	57	10/15/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $7,720,833

Issue Date FY: 2020 ( Subtotal = $7,817,616 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	004	57	9/14/2020	SUPPLEMENT FOR EXPANSION	$199,687
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	003	57	8/26/2020	SUPPLEMENT FOR EXPANSION	$148,434
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	57	3/31/2020	NON-COMPETING CONTINUATION	$7,070,833
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	002	57	8/25/2020	SUPPLEMENT FOR EXPANSION	$199,691
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	57	8/24/2020	SUPPLEMENT FOR EXPANSION	$198,971
														Subtotal = $7,817,616

Issue Date FY: 2019 ( Subtotal = $7,330,836 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	004	56	6/11/2019	SUPPLEMENT FOR EXPANSION	$200,003
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	003	56	6/7/2019	SUPPLEMENT FOR EXPANSION	$60,000
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	002	56	6/5/2019	NON-COMPETING CONTINUATION	$7,070,833
2019	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	54	10/22/2018	COMPETING CONTINUATION	$781
2019	2016	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	000	53	10/22/2018	EXTENSION WITH OR WITHOUT FUNDS	-$781
														Subtotal = $7,330,836

Issue Date FY: 2018 ( Subtotal = $7,328,078 ) (Continued on the next page)
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	009	55	7/18/2018	SUPPLEMENT FOR EXPANSION	$199,060
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	008	55	6/4/2018	SUPPLEMENT FOR EXPANSION	$59,984
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	005	55	4/16/2018	NON-COMPETING CONTINUATION	$7,069,034
2018	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	004	54	12/19/2017	COMPETING CONTINUATION	$721,975
2018	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	007	54	5/7/2018	COMPETING CONTINUATION	$2,532
2018	2016	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Cancer Centers Support Grants	001	53	12/19/2017	SUPPLEMENT FOR EXPANSION	-$60,000
Grand Total All Awards = $193,303,303

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Regional Oncology Research Center (Heterogeneity)

Award Number: P30CA006973

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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