Thursday, October 2, 2025 10/2/2025

Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application)

Award Number: P30AR079206
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/14/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application) - We seek to establish a new resource-based Center to foster and support research and training aimed at understanding the mechanisms underlying pain associated with musculoskeletal (MSK) and rheumatic diseases, with the ultimate goal of better managing and preventing it. One third of the world’s population is affected by chronic pain, and the MSK system is the most prevalent source of pain and disability. Currently available analgesic drugs act on a limited number of targets, and they do not provide sustained pain relief and their chronic use is associated with serious adverse effects. One of the major obstacles in identifying safe and efficacious drugs for producing pain relief is our general lack of understanding of the mechanisms underlying MSK pain, and how these mechanisms may overlap or differ between different types of rheumatic and MSK diseases. The Chicago Center on Musculoskeletal Pain (C-COMP) will address this need in a timely and unique manner, capitalizing on the world class expertise that is available to us in the areas of MSK research, pain and neurobiology to achieve the following broad long-term goals: (1) To integrate basic, translational and clinical expertise in a multidisciplinary Center which will provide the leadership and resources for promoting MSK pain research; (2) To enhance the research environment for the MSK research community by providing access to world-class expertise and state-of-the-art resources, technologies, and infrastructure for studying pain; (3) To promote interdisciplinary research between the MSK research field and the field of pain/neuroscience; (4) To expand the MSK pain research community by attracting early career as well as established researchers into this area of study. We envision three Cores operating in support of these overall goals. The Administrative Core A (PI: A.M. Malfait; co-director: J.J. Jacobs) will provide leadership, maintain effective communication, partner with related Centers to stimulate human translation of findings, and implement a dynamic enrichment program. The Behavioral Resource Core B (PI: R.E. Miller; co-director: D.R. Sumner) will provide a centralized resource to facilitate behavioral assays in a broad array of animal models of rheumatic and MSK diseases, including training for behavioral tests, access to customized protocols, equipment, and space to perform testing, a consultation service and a customized, full-service option for behavioral testing. The Neurobiology Core C (PI: RJ Miller; codirector: D.R. Sumner) will offer state-of-the-art techniques for assessment and manipulation of neuronal circuitry involved in pain physiology, such as in vivo calcium imaging, electrophysiology, chemo/optogenetics, transcriptomics/bioinformatics and neuroanatomical techniques. This will allow the Center’s research community to engage in cutting-edge investigations of the mechanisms of pain in animal models of MSK disease. In summary, C-COMP will provide (1) unique resources and infrastructure for supporting high-quality externally funded research and (2) pilot funding, education, and training in a multidisciplinary and collaborative fashion. This integrated approach is expected to accelerate research in pain associated with MSK and rheumatic disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $681,562 )
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	5	9/3/2025	NON-COMPETING CONTINUATION	$681,562
2025	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	8/19/2025	NON-COMPETING CONTINUATION	$0
2025	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	4/2/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $681,562

Issue Date FY: 2024 ( Subtotal = $761,693 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	005	4	8/14/2024	NON-COMPETING CONTINUATION	$761,693
2024	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	2/14/2024	NON-COMPETING CONTINUATION	$0
2024	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	10/27/2023	NON-COMPETING CONTINUATION	$0
2024	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	3	8/5/2024	NON-COMPETING CONTINUATION	$0
2024	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	3	5/16/2024	NON-COMPETING CONTINUATION	$0
2024	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	3	2/16/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $761,693

Issue Date FY: 2023 ( Subtotal = $844,965 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	7/21/2023	NON-COMPETING CONTINUATION	$765,965
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	3	9/7/2023	SUPPLEMENT FOR EXPANSION	$79,000
2023	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $844,965

Issue Date FY: 2022 ( Subtotal = $770,114 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	8/4/2022	NON-COMPETING CONTINUATION	$770,114
														Subtotal = $770,114

Issue Date FY: 2021 ( Subtotal = $788,393 )
2021	2021	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/14/2021	NEW	$788,393
														Subtotal = $788,393

Grand Total All Awards = $3,846,727

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Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application)

Award Number: P30AR079206

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/14/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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