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UW Center for Translational Muscle Research

Award Number: P30AR074990
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/05/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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UW Center for Translational Muscle Research - ABSTRACT - OVERALL The University of Washington (UW) Center for Translational Muscle Research (CTMR) will continue to provide critical resources and programs to enhance productivity of investigators to address multi-scale and multidisciplinary research of muscle disease and treatment strategies. Our research and clinical faculty at the UW, Seattle Childrens and the Fred Hutch Cancer Research Center have expertise in muscle disease and aging, exercise, and neuromuscular plasticity. The overall goal of the CTMR is to provide a unifying force to this Seattle area research community and beyond that accelerates innovative research by providing research tools, facilities, and expertise in a combination available only at the UW. This will facilitate novel insights into muscle pathologies and move new therapeutics towards the clinic and the marketplace. The CTMR offers 4 cores, one administrative and three research resource cores. The Administrative Core (A) provides program management and enrichment through symposia and workshops, seminar series, training and educational opportunities for new investigators and more experienced investigators moving into muscle research. It also administers a very successful Pilot Awards program that provides funding resources to test ideas, develop approaches and collect data that can be used for follow-on extramural research applications or ongoing projects. The Resource Cores feature multi-scale (physical and temporal) measurement and analytical tools. The Mechanics and Devices Core (B) provides state of the art measurements of muscle biomechanics at multiple levels of integration and develops new assays for maturation and assessment of early-stage muscle. The Metabolism and Energetics Core (C) provides tools for in depth measures and analysis of metabolomics, energetics, cell respiration and mitochondrial function. The Quantitative Analysis Core (D) provides computational and statistical tools for understanding mechanisms of function and dysfunction with disease and suggesting new therapeutic targets. The ability to gain information at multiple scales - from protein to organelles, cells, tissue, and organ - across energetic, metabolic, structure and functional domains using experimental and quantitative analytic tools with integrative capacity is a powerful approach that is not easily available to an individual investigator or research group. Such an interdisciplinary approach offers the capacity to accelerate research to better understand skeletal muscle aging, injury and diseases and speed therapeutics development. In the first 4 years, the CTMR has been significantly impactful on training and establishing new investigators in muscle research and facilitating movement of more established investigators into new research areas. The Resource Cores have developed or purchased new instrumentation and assays to meet the changing needs of CTMR faculty. In this renewal proposal we summarize forward looking efforts to remain at the forefront of research and development, so that - with essential support from the P30 – the CTMR will continue to meet the needs and be an indispensable resource for our growing muscle community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	6	1/6/2026	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $788,834 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	7	8/29/2025	NON-COMPETING CONTINUATION	$56,926
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	4/14/2025	NON-COMPETING CONTINUATION	$731,908
														Subtotal = $788,834

Issue Date FY: 2024 ( Subtotal = $813,231 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	005	6	8/27/2024	COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	6	8/26/2024	COMPETING CONTINUATION	$121,944
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	6	4/12/2024	COMPETING CONTINUATION	$813,231
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	10/24/2023	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	5	8/26/2024	NON-COMPETING CONTINUATION	-$121,944
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	4/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $813,231

Issue Date FY: 2023 ( Subtotal = $860,340 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	6/8/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	4/7/2023	NON-COMPETING CONTINUATION	$860,340
														Subtotal = $860,340

Issue Date FY: 2022 ( Subtotal = $860,340 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	4/20/2022	NON-COMPETING CONTINUATION	$860,340
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	4	8/5/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	4	5/18/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	11/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $860,340

Issue Date FY: 2021 ( Subtotal = $860,340 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	3/1/2021	NON-COMPETING CONTINUATION	$860,340
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	3	9/14/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	3	5/18/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	11/12/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $860,340

Issue Date FY: 2020 ( Subtotal = $860,340 )
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	9/23/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	3/9/2020	NON-COMPETING CONTINUATION	$860,340
														Subtotal = $860,340

Issue Date FY: 2019 ( Subtotal = $859,848 )
2019	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	4/5/2019	NEW	$859,848
														Subtotal = $859,848

Grand Total All Awards = $5,903,273

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UW Center for Translational Muscle Research

Award Number: P30AR074990

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/05/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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