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Indiana Core Center for Clinical Research in Musculoskeletal Health

Award Number: P30AR072581
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Indiana Core Center for Clinical Research in Musculoskeletal Health - Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The overarching goal of the Indiana Core Center for Clinical Research (ICCCR) – the Indiana Center for Musculoskeletal Health Clinical Research Center (ICMH-CRC) is to provide the needed training and resources to enhance clinical research in musculoskeletal disorders to improve musculoskeletal health across a broad range of diseases and populations. In Aim 1 we will deploy the Administrative Core to facilitate cross disciplinary clinical research by connecting MSK researchers with investigators studying chronic disease, enhance work with the community to educate, inform, recruit and assess disadvantaged and minoritized populations, provide pilot funding, and train the next generation of musculoskeletal researchers. We will innovate through increased community engagement with racial and ethnically diverse populations to encourage participation in MSK research. In Aim 2, we will integrate and harmonize big data from multiple data sources in the Musculoskeletal Informatics Methodology (MIM) Core. We will develop a facile, secure and innovative MSK Data Mart that integrates and harmonizes 1) The state-wide “traditional” electronic health record (EHR), 2) Measures of social and structural determinants of health based on geocoding, 3) The prospective collection of data from the FIT Core, and 4) genomics and sample availability from the MSK Biobank. The Data Mart will expand our core linkage and maximize MSK assessment based on the computable (computer data derived) phenotypes developed and refined during our first P30. In Aim 3, we will foster growth of the Musculoskeletal Function, Imaging, and Tissue (FIT) Resource Core to provide standardized assessments of musculoskeletal health and expand the availability of biospecimens to facilitate exploration of musculoskeletal health and disease. We will innovate our resource Core (FIT Core) by taking the Core “on the road’ to the community health centers and organizations, diversifying our tested population to develop race and ethnicity specific Z scores. We will also perform whole exome sequencing on DNA collected from the participants to expand the utility of the MSK functional (physical function), morphologic (imaging), and computable (electronic health record) phenotypes by linking with genomic data. These goals will serve to promote and advance clinical research in MSK disorders leading to prevention, diagnosis, treatment and cure for ALL individuals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	12/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $649,835 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	9	9/17/2025	NON-COMPETING CONTINUATION	$649,835
														Subtotal = $649,835

Issue Date FY: 2024 ( Subtotal = $753,045 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	8	9/6/2024	NON-COMPETING CONTINUATION	$753,045
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	3/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $753,045

Issue Date FY: 2023 ( Subtotal = $770,161 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	7	7/14/2023	NON-COMPETING CONTINUATION	$770,161
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	6	5/10/2023	COMPETING CONTINUATION	$0
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	6	3/31/2023	COMPETING CONTINUATION	$365,414
2023	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	3/31/2023	NON-COMPETING CONTINUATION	-$365,414
														Subtotal = $770,161

Issue Date FY: 2022 ( Subtotal = $786,796 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	6	9/20/2022	COMPETING CONTINUATION	$786,796
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	9/12/2022	NON-COMPETING CONTINUATION	$0
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	12/21/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $786,796

Issue Date FY: 2021 ( Subtotal = $776,745 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	5	8/11/2021	NON-COMPETING CONTINUATION	$776,745
2021	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	1/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $776,745

Issue Date FY: 2020 ( Subtotal = $776,745 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	8/27/2020	NON-COMPETING CONTINUATION	$776,745
2020	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	1/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $776,745

Issue Date FY: 2019 ( Subtotal = $776,745 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	8/9/2019	NON-COMPETING CONTINUATION	$776,745
2019	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $776,745

Issue Date FY: 2018 ( Subtotal = $776,745 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/3/2018	NON-COMPETING CONTINUATION	$776,745
														Subtotal = $776,745

Issue Date FY: 2017 ( Subtotal = $805,495 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/19/2017	NEW	$805,495
														Subtotal = $805,495

Grand Total All Awards = $6,872,312

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Indiana Core Center for Clinical Research in Musculoskeletal Health

Award Number: P30AR072581

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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