Thursday, September 18, 2025 9/18/2025

Alzheimer's Disease Research Centers

Award Number: P30AG066530
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Alzheimer's Disease Research Centers - Overall: Project Summary – 2P30AG066444-06 The Washington University Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC) initiates, fosters, and supports the performance of innovative, cutting-edge research on Alzheimer disease (AD) and related dementias (ADRD) with regard to the etiology, pathogenesis, diagnosis, treatment, and prevention of disease. We provide well-characterized research participants (persons with symptomatic AD and age-matched controls), their clinical, cognitive, and imaging data, and their biospecimens (DNA, CSF, plasma, dermal fibroblasts, iPSCs, brain tissue) to research projects. We also provide intellectual and financial support to scientists at Washington University, other Alzheimer Disease Research Centers, and the research community nationally and internationally and engage in formal and informal collaborations, including multidisciplinary/multi-Center studies and the initiatives sponsored by the National Institute on Aging and the National Alzheimer Coordinating Center. Historically, our Center has focused on the earliest stages of dementia to identify the initial clinical and pathologic changes that distinguish AD from normal aging. Our approach is balanced between clinical and basic science domains with emphasis on interdisciplinary efforts. We will continue our training of students, fellows, and junior faculty in clinical and basic science research skills. We will continue to engage in outreach activities to transfer information on ADRD to lay and professional audiences. We are committed to assuring that our research cohort includes individuals at higher risk for dementia from the greater metropolitan St. Louis area. This renewal application includes eight Cores, plus the Research Education Component (REC): A: Administrative, B: Clinical, C: Data Management & Statistics, D: Neuropathology, E: Outreach, Recruitment, & Engagement, F: Biomarker, G: Genetics & High Throughput -Omics, and H: Health Disparities Engagement.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $4,770,384 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	001	6	7/30/2025	COMPETING CONTINUATION	$4,770,384
2025	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	000	5	6/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,770,384

Issue Date FY: 2024 ( Subtotal = $1 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	003	5	8/14/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	002	5	6/6/2024	NON-COMPETING CONTINUATION	$1
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	000	4	6/4/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	001	4	6/4/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1

Issue Date FY: 2023 ( Subtotal = $3,266,231 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	003	4	6/28/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	001	4	6/9/2023	SUPPLEMENT FOR EXPANSION	$34,650
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	000	4	6/8/2023	NON-COMPETING CONTINUATION	$3,231,581
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	002	4	6/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,266,231

Issue Date FY: 2022 ( Subtotal = $3,416,603 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	2	10/25/2021	SUPPLEMENT FOR EXPANSION	$57,173
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	005	3	9/2/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	003	3	7/1/2022	SUPPLEMENT FOR EXPANSION	$69,300
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	004	3	7/5/2022	SUPPLEMENT FOR EXPANSION	$58,549
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	002	3	6/29/2022	NON-COMPETING CONTINUATION	$3,231,581
2022	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	001	2	1/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,416,603

Issue Date FY: 2021 ( Subtotal = $3,212,081 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	004	2	8/16/2021	SUPPLEMENT FOR EXPANSION	$34,650
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	003	2	6/7/2021	NON-COMPETING CONTINUATION	$3,231,581
2021	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	1	10/19/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	001	1	3/2/2021	NEW	-$54,150
2021	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	002	1	4/5/2021	NEW	$0
														Subtotal = $3,212,081

Issue Date FY: 2020 ( Subtotal = $3,698,231 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	001	1	8/31/2020	SUPPLEMENT FOR EXPANSION	$412,500
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Aging Research	000	1	8/26/2020	NEW	$3,285,731
														Subtotal = $3,698,231

Grand Total All Awards = $18,363,531

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Alzheimer's Disease Research Centers

Award Number: P30AG066530

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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