Thursday, December 18, 2025 12/18/2025

Alzheimer's Disease Research Center

Award Number: P30AG066514
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Alzheimer's Disease Research Center - Mount Sinai ADRC (Sano): OVERALL – Research Summary Alzheimer's disease (AD) is a major health threat to the nation and the world causing great human pain and economic loss. While some advances have been made in detection and raising awareness, finding treatments has remained unsuccessful in spite of decades of research. To date, efforts have focused on defining the disease by a narrow characterization of end-stage pathology, using restrictive samples and technologies that systematically exclude the diversity of the disease. This approach has led to multiple failures, resulting in scant progress on the therapeutic front. With this backdrop, the Mount Sinai Alzheimer's Disease Research Center (MSADRC), with its history of success in therapeutic development dedicates itself anew to identify and develop effective approaches to treating AD. Co-located in Manhattan on the Mount Sinai campus and in the Bronx at the James J Peters Veterans Administration Medical Center, we bring the strength of two premiere institutions to the mission of finding a treatment for AD. This application builds on these institutional strengths including systems- based approaches to scientific inquiry, using the computational tools to mine big data and our established expertise in recruiting diverse populations. We propose as our theme “Understanding disease heterogeneity to optimize therapeutic approaches to treat and cure Alzheimer's disease” as it aligns our strengths with the implementation areas and milestones of the National Alzheimer's Project Act (NAPA). We propose 7 cores (Administrative, Clinical, Biomarker, Genetics, Neuropathology, Data, and Outreach) and a Research Education Component, all of which have outstanding leadership reflecting newly recruited faculty as well investigators with established histories at the MSADRC. Using the collaborative efforts of the Clinical and Outreach Core, enhanced by novel methods of patient engagement through the electronic medical records at both locations, we propose to expand and maintain a cohort of 450 diverse individuals, 40% of whom will be from under-represented minorities, all receiving annual clinical evaluations, genetic analysis, and blood biomarker collection. The Genetics Core will collect genetics data on all, generate GWAS, and will obtain plasma samples for established biomarkers and proteomics on this diverse cohort. Our new Biomarker Core, supported by new philanthropy and existing research efforts will obtain structural and functional imaging on all patients, and molecular phenotyping with CSF biomarkers or molecular imaging on at least 50% of the cohort, capturing its full diversity. The Neuropathology Core, expanding collection beyond brain to other relevant tissues and body fluids obtained at autopsy, will allow the preparation of relevant brain regions for unbiased systematic sampling (stereology) and autopsy-derived specimens for iPS, multiomics, microbiome, and exosome studies. The Data Core, enhanced by the addition of the Senior Associate Dean for Scientific Computing and Data Science as Core Co-Leader, will expand the capacity to integrate and share the Core's resources to facilitate interdisciplinary collaborations and create an environment that fosters innovative approaches to finding treatments and cures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	6	12/9/2025	COMPETING CONTINUATION	$0
2026	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	6	11/22/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $4,736,762 )
2025	2025	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	6	6/2/2025	COMPETING CONTINUATION	$4,736,863
2025	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	5	7/13/2025	NON-COMPETING CONTINUATION	-$101
														Subtotal = $4,736,762

Issue Date FY: 2024 ( Subtotal = $3,034,446 )
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	002	5	9/13/2024	NON-COMPETING CONTINUATION	$0
2024	2024	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	5	4/24/2024	NON-COMPETING CONTINUATION	$3,034,446
2024	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	4	10/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,034,446

Issue Date FY: 2023 ( Subtotal = $3,458,408 )
2023	2023	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	4	4/5/2023	NON-COMPETING CONTINUATION	$3,458,408
2023	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	3	10/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,458,408

Issue Date FY: 2022 ( Subtotal = $3,464,531 )
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	3	4/26/2022	NON-COMPETING CONTINUATION	$3,042,031
2022	2022	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	002	3	4/27/2022	SUPPLEMENT FOR EXPANSION	$422,500
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	2	11/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,464,531

Issue Date FY: 2021 ( Subtotal = $3,041,622 )
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	003	2	8/23/2021	NON-COMPETING CONTINUATION	$0
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	002	2	5/18/2021	NON-COMPETING CONTINUATION	$3,041,622
2021	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	1	4/23/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	1	12/10/2020	NEW	$0
														Subtotal = $3,041,622

Issue Date FY: 2020 ( Subtotal = $3,767,432 )
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	000	1	4/24/2020	NEW	$3,029,312
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	001	1	8/17/2020	NEW	$0
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	003	1	9/3/2020	SUPPLEMENT FOR EXPANSION	$314,370
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Aging Research	002	1	8/31/2020	SUPPLEMENT FOR EXPANSION	$423,750
														Subtotal = $3,767,432

Grand Total All Awards = $21,503,201

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Alzheimer's Disease Research Center

Award Number: P30AG066514

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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