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Wisconsin Alzheimer's Disease Research Center

Award Number: P30AG062715
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Wisconsin Alzheimer's Disease Research Center - PROJECT SUMMARY - OVERALL The overarching goal of the renewal of the Wisconsin Alzheimer’s Disease Research Center (ADRC) is to conduct breakthrough research on the pathobiology, preclinical biomarkers, early diagnosis, treatment, and prevention of Alzheimer’s disease (AD) and related dementias. This goal will be accomplished by establishing a stimulating, interdisciplinary environment for collaborative, equitable, and generalizable research that provides invaluable clinical data, ante-mortem biospecimens, and autopsy brain tissue. Funded by NIA in 2009, the Wisconsin ADRC will oversee eight well-integrated Cores and the Research Education Component that will support timely, innovative research, which will: 1) characterize preclinical biomarkers of AD and their role in predicting transition from preclinical to clinical stages of the disease; 2) investigate the neurobiology of AD; 3) identify novel vascular and genetic risk factors, linking them to the disease pathology and clinical phenotype; 4) incorporate contemporary biochemical and molecular techniques into clinical-pathologic cohort studies, including multidimensional omics and next generation sequencing; and 5) participate and facilitate the missions of other federal, state, and local agency-supported aging and dementia research programs. The overall goals of the Center will be accomplished through coordinated activities of its eight Cores and the REC. The Administrative Core will provide scientific leadership to the ADRC. The Clinical Core will perform standardized evaluations and collect UDS and additional data on all research participants. It will work closely with the Outreach, Recruitment and Engagement (ORE) and the Inclusion of Underrepresented Groups (IURG) Cores to enhance enrollment of participants from underrepresented groups. The Data Management and Statistical (DMS) Core will continue to meet all data management, informatics, and statistical needs and support all the PC- and web-based services and processes. The Neuropathology Core will continue to provide neuropathologic diagnoses and process, store, and distribute antemortem biospecimens and postmortem brain tissue to support novel research in AD. The ORE Core will provide a broad-range of educational and community outreach programs about AD and support the Wisconsin ADRC’ goal to recruit research volunteers, especially those from URGs into the Clinical Core and other NIA-funded initiatives, such as ACTC, ADCS, ADNI, NCRAD and GWAS studies. The IURG Core will work closely with the ORE and Clinical Cores to enhance recruitment and retention of URG participants into the ADRC. The Biomarker Core will support and provide access to resources in preclinical neuroimaging and fluid biomarkers of AD. The REC will coordinate closely with the Clinical, ORE, IURG, Neuropathology, and DMS Cores to provide state-of-the-art, competency-based training to learners of varied backgrounds and levels of training, including high school students, undergraduates, doctoral students, postdoctoral fellows, and early-stage faculty in all aspects of aging & dementia research. The Care Research Core will provide novel expertise and resources to conduct innovative studies that will enhance patient care and change clinical practice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	001	6	2/14/2025	COMPETING CONTINUATION	$4,726
2025	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	5	2/14/2025	NON-COMPETING CONTINUATION	-$4,726
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $4,451,960 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	6	6/12/2024	COMPETING CONTINUATION	$4,451,960
														Subtotal = $4,451,960

Issue Date FY: 2023 ( Subtotal = $3,013,796 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	001	5	4/19/2023	NON-COMPETING CONTINUATION	$3,013,796
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	002	5	5/23/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	000	4	12/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,013,796

Issue Date FY: 2022 ( Subtotal = $3,014,887 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Aging Research	001	4	4/4/2022	NON-COMPETING CONTINUATION	$3,014,887
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	3	10/21/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,014,887

Issue Date FY: 2021 ( Subtotal = $3,056,445 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	001	3	4/6/2021	NON-COMPETING CONTINUATION	$3,056,445
2021	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	2	11/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,056,445

Issue Date FY: 2020 ( Subtotal = $4,356,415 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	004	2	9/4/2020	SUPPLEMENT FOR EXPANSION	$387,035
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	2	3/9/2020	NON-COMPETING CONTINUATION	$3,466,632
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	002	2	8/14/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	003	2	8/28/2020	SUPPLEMENT FOR EXPANSION	$347,774
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	001	2	8/7/2020	SUPPLEMENT FOR EXPANSION	$154,974
														Subtotal = $4,356,415

Issue Date FY: 2019 ( Subtotal = $3,406,220 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	001	1	7/14/2019	SUPPLEMENT FOR EXPANSION	$343,420
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	000	1	4/29/2019	NEW	$3,006,041
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Aging Research	002	1	9/3/2019	SUPPLEMENT FOR EXPANSION	$56,759
														Subtotal = $3,406,220

Grand Total All Awards = $21,299,723

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Wisconsin Alzheimer's Disease Research Center

Award Number: P30AG062715

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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