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Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging

Award Number: P30AG050911
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging - ABSTRACT/SUMMARY – OVERALL Advances in understanding of molecular mechanisms of aging in the last decades, including the discovery of manipulations that delay aging and increase healthspan, led to the creation of a new field of study, geroscience. The translation of current knowledge of aging to interventions to prevent or treat age-associated dysfunction and disease, however, is limited. The Oklahoma Nathan Shock Center (NSC, `Center') focuses on geroscience, unique among NSCs. Geroscience is central to the goals and strengths of our host institutions: the University of Oklahoma Health Sciences (OUHSC), the Oklahoma Medical Research Foundation (OMRF), and the Oklahoma City VA Medical Center (VAHCS). The primary goal of the NSC is to serve as a national resource to enable sustained, accelerated progress in biology of aging and geroscience research, to help bring interventions to the clinic sooner. We will achieve our goal by (1) Offering investigators access to unique advanced technologies to enable transformative basic and translational research on aging/geroscience; (2) Providing intellectual and organizational leadership to the field; (3) Disseminating knowledge of aging biology and its association with human disease; (4) Providing intensive mentoring to early-stage investigators to become the next generation of leaders in aging/geroscience research; (5) Promoting access and opportunity for all investigators in all Center's activities, specially early-stage investigators; and (6) Disseminating knowledge of aging and geroscience to our local and national communities. We will regularly and objectively evaluate progress towards these goals. The aging/ geroscience research program in Oklahoma, nucleated by the NSC, has grown 450% since the Center's inception in 2015 and promoted growth of aging/geroscience research in the nation. The NSC has provided 554 services (285 this cycle), largely to external investigators, with 111 publications and 58 funded investigator-initiated grants in this funding cycle. Seven outstanding early-stage investigators (6 external) are currently in our Mentorship Program. Through the coordinated, cohesive activities of our Cores and the Center's interactions with local programs, other NSCs (U Washington, U Alabama, and JAX), and the NSC3, our proposed Center will continue to achieve a whole that is greater than its individual parts. Together with our administrative and research development cores, we will achieve our Center's goal through the (1) Multiplexing Protein Analysis Core, that provides data- independent acquisition mass spectrometry and metabolic labeling to measure protein steady-state levels and turnover rates; (2) Genomic Sciences Core, that maps the epigenome and measures mitochondrial heteroplasmy and copy number using next-generation or long-read nanopore sequencing; (3) Redox Biology Core, that measures redox status (including radical species), oxidative damage, and mitochondrial function (also in frozen tissues), and related metabolites; and (4) CRISPR Whole-Genome Screening Core, that uses CRISPR to knock out individual genes, one by one, in a high-throughput, rapid fashion, to identify those that mediate aging or age- associated disease phenotypes modeled in practically any human or mouse cell type, including primary cells.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	11	12/31/2025	COMPETING CONTINUATION	$0
2026	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	002	11	3/3/2026	COMPETING CONTINUATION	$0
2026	2024	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	10	2/11/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,325,136 )
2025	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	11	6/16/2025	COMPETING CONTINUATION	$1,325,136
2025	2025	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	002	11	7/15/2025	COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	10	5/29/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,325,136

Issue Date FY: 2024 ( Subtotal = $1,060,578 )
2024	2024	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	10	5/13/2024	NON-COMPETING CONTINUATION	$1,060,578
2024	2023	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	9	4/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,060,578

Issue Date FY: 2023 ( Subtotal = $1,060,578 )
2023	2023	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	9	6/20/2023	NON-COMPETING CONTINUATION	$1,060,578
2023	2022	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	8	10/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,060,578

Issue Date FY: 2022 ( Subtotal = $1,060,579 )
2022	2022	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	002	8	7/28/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	8	6/17/2022	NON-COMPETING CONTINUATION	$1,060,579
2022	2021	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	7	11/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,060,579

Issue Date FY: 2021 ( Subtotal = $1,199,747 )
2021	2021	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	002	7	6/8/2021	NON-COMPETING CONTINUATION	$1,060,577
2021	2021	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Trans-NIH Research Support	007	7	9/1/2021	SUPPLEMENT FOR EXPANSION	$139,170
2021	2020	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	006	6	8/24/2021	COMPETING CONTINUATION	$172,335
2021	2020	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	004	6	8/11/2021	COMPETING CONTINUATION	-$172,335
2021	2020	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	6	4/16/2021	COMPETING CONTINUATION	$172,335
2021	2019	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	5	4/16/2021	NON-COMPETING CONTINUATION	-$172,335
2021	2019	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	005	5	8/24/2021	NON-COMPETING CONTINUATION	-$172,335
2021	2019	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	003	5	8/11/2021	NON-COMPETING CONTINUATION	$172,335
														Subtotal = $1,199,747

Issue Date FY: 2020 ( Subtotal = $1,060,577 )
2020	2020	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	002	6	9/11/2020	COMPETING CONTINUATION	$1,060,577
2020	2019	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	5	7/9/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	5	9/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,060,577

Issue Date FY: 2019 ( Subtotal = $744,426 )
2019	2019	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	5	7/16/2019	NON-COMPETING CONTINUATION	$744,426
2019	2018	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	4	1/31/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $744,426

Issue Date FY: 2018 ( Subtotal = $1,115,765 )
2018	2018	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	4	9/6/2018	SUPPLEMENT FOR EXPANSION	$370,000
2018	2018	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	4	6/28/2018	NON-COMPETING CONTINUATION	$745,765
														Subtotal = $1,115,765

Issue Date FY: 2017 ( Subtotal = $1,069,062 )
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	002	3	7/3/2017	NON-COMPETING CONTINUATION	$746,562
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	008	3	9/22/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	007	3	9/21/2017	SUPPLEMENT FOR EXPANSION	$148,000
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	006	3	9/21/2017	SUPPLEMENT FOR EXPANSION	-$148,000
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	005	3	9/20/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	004	3	9/19/2017	SUPPLEMENT FOR EXPANSION	$174,500
2017	2017	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	003	3	9/18/2017	SUPPLEMENT FOR EXPANSION	$148,000
2017	2016	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	001	2	12/6/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$4,175
2017	2015	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Aging Research	000	1	12/6/2016	NEW	-$4,175
														Subtotal = $1,069,062

Issue Date FY: 2016 ( Subtotal = $896,540 )
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Aging Research	000	2	7/29/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$748,540
2016	2016	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Aging Research	001	2	9/9/2016	SUPPLEMENT FOR EXPANSION	$148,000
														Subtotal = $896,540

Grand Total All Awards = $11,356,475

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Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging

Award Number: P30AG050911

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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