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Conserved Transcriptional Response to Adversity (CTRA) and COVID-19: Role of Pre-existing Neighborhood Characteristics and Cognitive Impairment

Award Number: P30AG049638
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Conserved Transcriptional Response to Adversity (CTRA) and COVID-19: Role of Pre-existing Neighborhood Characteristics and Cognitive Impairment - Bateman et al., NOT-AG-20-022 2020 PROJECT SUMMARY The proposed administrative supplement will fund an investigation of the impact of COVID-19 on participants of the Wake Forest Alzheimer’s Disease Research Center (ADRC). We will determine the impact of COVID-19 related social distancing and stress on individuals with cognitive impairment as compared to older adults with normal cognition in the WF ADRC center cohort. The proposed supplement will be conducted in the Clinical Core cohort of the ADRC at Wake Forest School of Medicine, and falls within the general scope of the ADRC of identifying factors that modulate cognitive decline in aging and Alzheimer’s disease, and synergizes with our center’s focus on health disparities by utilizing a metric of neighborhood disadvantage. The proposal is based on evidence that loneliness and stress are associated with cognitive decline and are expected to be more prevalent as a result of social distancing public health measures for the prevention of COVID-19 spread. Several prior studies have shown that loneliness is associated with chronic stress in older adults, and that loneliness is further associated with cognitive decline, with some suggestion of a bidirectional relationship. Loneliness has been shown to be affected by neighborhood variables as well. Our proposed supplement will examine the impact of COVID-19 on loneliness and stress, and determine whether participants with pre- pandemic cognitive impairment, or those living in more deprived neighborhoods, are more vulnerable to the impact. There are two parts to our proposed study: a telephone-based questionnaire visit and dried blood spot collection for transcriptional analysis. We will collected two questionnaires focused on the impact of COVID-19, as well as questionnaires to assess perceived stress, loneliness, coping strategies, and psychological well- being. Each participant will be geocoded and their area deprivation index will be obtained based on publically- available data. A new collaborative relationship has been established with the UCLA Social Genomics Core which will perform the RNA extraction and analysis. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$22,152 )
2023	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	5	8/9/2023	SUPPLEMENT FOR EXPANSION	-$22,152
														Subtotal = -$22,152

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	5	5/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $3,346,280 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	005	5	8/14/2020	SUPPLEMENT FOR EXPANSION	$316,108
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	002	5	6/17/2020	SUPPLEMENT FOR EXPANSION	$152,153
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	001	5	6/11/2020	NON-COMPETING CONTINUATION	$2,878,019
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	004	5	8/3/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	003	5	7/6/2020	NON-COMPETING CONTINUATION	$0
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	006	5	8/20/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	4	11/1/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,346,280

Issue Date FY: 2019 ( Subtotal = $3,278,692 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	002	4	7/26/2019	SUPPLEMENT FOR EXPANSION	$309,715
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	4	7/22/2019	NON-COMPETING CONTINUATION	$1,945,326
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	001	4	7/25/2019	SUPPLEMENT FOR EXPANSION	$1,023,651
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	003	4	8/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,278,692

Issue Date FY: 2018 ( Subtotal = $1,916,759 )
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	3	7/31/2018	NON-COMPETING CONTINUATION	$1,770,906
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	002	3	9/24/2018	SUPPLEMENT FOR EXPANSION	$145,853
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	001	3	9/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,916,759

Issue Date FY: 2017 ( Subtotal = $1,901,797 )
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	001	2	8/28/2017	SUPPLEMENT FOR EXPANSION	$155,000
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	2	7/14/2017	NON-COMPETING CONTINUATION	$1,746,797
														Subtotal = $1,901,797

Issue Date FY: 2016 ( Subtotal = $1,746,765 )
2016	2016	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Aging Research	000	1	8/25/2016	NEW	$1,746,765
														Subtotal = $1,746,765

Grand Total All Awards = $12,168,141

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Conserved Transcriptional Response to Adversity (CTRA) and COVID-19: Role of Pre-existing Neighborhood Characteristics and Cognitive Impairment

Award Number: P30AG049638

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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