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Arizona Alzheimer's Disease Core Center

Award Number: P30AG019610
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2001
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Arizona Alzheimer's Disease Core Center - PROJECT SUMMARY/ABSTRACT The coronavirus SARS-CoV-2 (Covid-19 or 2019-nCoV) emerged in Wuhan, China, in late 2019 and then rapidly spread worldwide. It causes severe acute respiratory syndrome, SARS, with substantial morbidity and mortality. Little is yet known whether the CNS is involved, but other coronaviruses are known to invade the brain. There is as yet, however, no published data on the presence or neuropathological consequences of CNS SARS-CoV-2 in infected humans. This project aims to fill this important knowledge gap. The Arizona ADCC became the NIA's first statewide AD Center in 2001. Since then, it has established Clinical and Neuropathology Cores that are world-class resources of longitudinally assessed individuals, and, together with an extraordinary ancillary Brain and Body Donation Program, annually contribute on average 80 autopsied subjects. In this supplemental application we propose to conduct important studies probing the extent and consequences of SARS-CoV-2 CNS infection in an estimated 100 or more subjects coming to autopsy over an 18 month period spanning the global pandemic. The project is supported by an extremely strong, multidisciplinary team. Specific Aim 1 will determine the prevalence of CNS infection with SARS-CoV-2 in consecutive autopsies, using postmortem nasal swab, postmortem blood serology and assay of multiple brain regions for SARS-CoV-2 RNA. Specific Aim 2 will assess the gene expression effects of brain regional SARS-CoV-2 infection using RNAseq transcriptomics. Deconvolution analysis will infer gene expression changes separately for neurons, microglia, astrocytes, oligodendrocytes and endothelial cells. Hypothetical gene expression effects would include those typical for inflammatory responses, cell death and demyelination. Additionally, this analysis will put SARS-CoV-2 findings into perspective vs other microbial or viral presence as detected by their specific transcripts, reflecting past pathogen exposure history. Specific Aim 3 will determine the neuropathological correlates of the findings from Specific Aims 1 and 2, by surveying the brain for typical viral-associated histopathology including meningitis, encephalitis, microglial nodules, perivascular mononuclear cell cuffing and demyelination, and by determining with immunohistochemistry and in-situ hybridization whether specific cell types are infected. These findings may yield critical clues useful for devising diagnostic and therapeutic strategies for possible neurological manifestations of SARS-CoV-2 and the planned studies provide an unprecedented opportunity to survey the prevalence and extent of brain invasion by a novel pathogen during a worldwide pandemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$16 )
2024	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	001	20	1/22/2024	SUPPLEMENT FOR EXPANSION	-$2
2024	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	21	1/22/2024	NON-COMPETING CONTINUATION	-$14
														Subtotal = -$16

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	21	6/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	21	3/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $3,385,924 )
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	005	21	6/19/2020	NON-COMPETING CONTINUATION	$2,978,035
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	004	20	6/11/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	002	20	5/21/2020	SUPPLEMENT FOR EXPANSION	$407,889
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	006	21	7/27/2020	NON-COMPETING CONTINUATION	$0
2020	2020	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	003	20	6/9/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	001	20	4/22/2020	NON-COMPETING CONTINUATION	$0
2020	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	20	3/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,385,924

Issue Date FY: 2019 ( Subtotal = $2,979,062 )
2019	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	004	20	8/21/2019	NON-COMPETING CONTINUATION	$0
2019	2019	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	003	20	7/12/2019	NON-COMPETING CONTINUATION	$2,979,062
2019	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	002	19	6/12/2019	NON-COMPETING CONTINUATION	$0
2019	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	001	19	2/5/2019	NON-COMPETING CONTINUATION	$0
2019	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	19	10/29/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,979,062

Issue Date FY: 2018 ( Subtotal = $2,991,508 )
2018	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	001	19	9/12/2018	SUPPLEMENT FOR EXPANSION	$1,242,362
2018	2018	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	19	8/3/2018	NON-COMPETING CONTINUATION	$1,749,146
														Subtotal = $2,991,508

Issue Date FY: 2017 ( Subtotal = $1,750,408 )
2017	2017	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	004	18	7/14/2017	NON-COMPETING CONTINUATION	$1,750,408
2017	2016	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	001	17	1/13/2017	COMPETING CONTINUATION	$75,516
2017	2016	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	003	17	5/11/2017	COMPETING CONTINUATION	$2,272
2017	2015	BANNER HEALTH	2901 N CENTRAL AVE	PHOENIX	AZ	85012	MARICOPA	USA	Aging Research	002	16	5/11/2017	NON-COMPETING CONTINUATION	-$2,272
2017	2015	BANNER HEALTH	2901 N CENTRAL AVE	PHOENIX	AZ	85012	MARICOPA	USA	Aging Research	000	16	1/13/2017	NON-COMPETING CONTINUATION	-$75,516
														Subtotal = $1,750,408

Issue Date FY: 2016 ( Subtotal = $1,817,195 )
2016	2016	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Aging Research	001	17	8/3/2016	COMPETING CONTINUATION	$1,817,195
2016	2015	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	16	7/29/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,817,195

Issue Date FY: 2015 ( Subtotal = $1,393,937 )
2015	2015	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	000	16	7/14/2015	NON-COMPETING CONTINUATION	$1,393,937
														Subtotal = $1,393,937

Issue Date FY: 2014 ( Subtotal = $1,506,232 )
2014	2014	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	003	15	9/9/2014	SUPPLEMENT FOR EXPANSION	$62,500
2014	2014	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	002	15	7/14/2014	NON-COMPETING CONTINUATION	$1,443,732
2014	2013	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	001	14	2/13/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,060,404
2014	2013	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	13	2/12/2014	NON-COMPETING CONTINUATION	-$1,060,404
														Subtotal = $1,506,232

Issue Date FY: 2013 ( Subtotal = $1,356,753 )
2013	2013	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	13	6/28/2013	NON-COMPETING CONTINUATION	$1,356,753
2013	2013	BANNER HEALTH	1441 NORTH 12TH STREET	PHOENIX	AZ	85006	MARICOPA	USA	Aging Research	002	14	2/13/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,060,404
2013	2013	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	001	13	2/12/2014	NON-COMPETING CONTINUATION	-$1,060,404
														Subtotal = $1,356,753

Issue Date FY: 2012 ( Subtotal = $1,461,758 )
2012	2012	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	12	6/29/2012	NON-COMPETING CONTINUATION	$1,461,758
														Subtotal = $1,461,758

Issue Date FY: 2011 ( Subtotal = $1,631,973 )
2011	2011	SUN HEALTH RESEARCH INSTITUTE	P.O. BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	001	11	8/12/2011	COMPETING CONTINUATION	$1,631,973
2011	2010	SUN HEALTH RESEARCH INSTITUTE	POST OFFICE BOX 1278	SUN CITY	AZ	85372	MARICOPA	USA	Aging Research	000	10	8/11/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,631,973

Issue Date FY: 2010 ( Subtotal = $1,475,375 ) (Continued on the next page)
Grand Total All Awards = $32,493,527

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Arizona Alzheimer's Disease Core Center

Award Number: P30AG019610

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2001

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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