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Nathan Shock Centers of Excellence in Basic Biology of Aging (P30 Clinical Trial Not Allowed)

Award Number: P30AG013280
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/1997
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Nathan Shock Centers of Excellence in Basic Biology of Aging (P30 Clinical Trial Not Allowed) - OVERALL – PROJECT SUMMARY We propose this renewal application for the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging (UW NSC). The UW NSC has been a leader in providing innovative resources and expertise to the geroscience community for over 30 years. The proposed center resources will continue this history of high impact through outreach to connect investigators in the biology of aging with our set of highly collaborative cores that offer state of the art technologies. These core services are centered around translating complex high dimensional datasets, including multi-omics, into mechanistic insights into the biology of aging. The Protein Phenotypes of Aging (Core C – Michael MacCoss and Judit Villen) provides advanced tools to quantify how changes in the proteome, including turnover and stability, post-translational modifications, and protein interactions, in addition to protein expression, drive aging biology. The Metabolic Phenotypes of Aging Core (Core D – Daniel Raftery and David Marcinek) uses advanced mass spectrometry, NMR, and mitochondrial assays to quantify changes in metabolism and signaling with age. Cores C and D provide tools for generating and testing mechanistic hypotheses, as well as support for development of biological aging clocks and biomarker analyses for clinical trials. The Invertebrate Models of Aging Core (Core E – Maitreya Dunham and Alex Mendenhall) offers unique high throughput phenotyping, gene editing, and chemostat technology to link high dimension data to whole organism (C. elegans) and cellular aging (S. cerevisiae). The Explainable Artificial Intelligence (XAI) for Aging Core (Core F – Su-In Lee) provides a link between the three other resource cores by applying and enhancing Dr. Lee’s novel XAI technology to move beyond black box AI techniques to create biologically interpretable mechanistic insights from high dimensional and multi-omics data. The Research Development Core (Core B – Jessica Young and Mariya Sweetwyne) will connect external investigators and junior faculty to the UW NSC Resource Cores through support for traditional pilot projects (up to $30,000 each) and RFAs for integrative pilots that involve multiple Resource Cores (up to $50,000 each). Core B will also work to “build the bench” of new geroscientists by setting aside $10,000 to support 2-3 summer research projects in the basic biology of aging for undergraduates and high school students from under-represented groups. The Administration and Program Enrichment Core (Core A – David Marcinek and Jessica Young) will support the UW NSC with budget management, outreach and scientific direction through coordination of external advisory boards, symposia and external speakers, training workshops for the Resource Cores, and collaboration with other centers. Core A will also provide bioinformatic and statistical support for rigorous experimental design and analysis for all UW NSC projects. Core A will also support a new initiative to capitalize on the affiliations of the new UW NSC leadership to connect basic scientists to publicly available databases from large cohort studies to facilitate testing the translational potential of mechanistic insights from lab models to human aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	31	12/12/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,294,617 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	31	6/16/2025	COMPETING CONTINUATION	$1,294,617
2025	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	30	10/23/2024	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	30	6/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,294,617

Issue Date FY: 2024 ( Subtotal = $962,037 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	30	6/5/2024	NON-COMPETING CONTINUATION	$962,037
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	29	1/6/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	29	10/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $962,037

Issue Date FY: 2023 ( Subtotal = $962,040 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	29	6/7/2023	NON-COMPETING CONTINUATION	$962,040
2023	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	28	10/21/2022	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	28	3/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $962,040

Issue Date FY: 2022 ( Subtotal = $962,038 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	28	7/22/2022	NON-COMPETING CONTINUATION	$962,038
2022	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	27	11/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $962,038

Issue Date FY: 2021 ( Subtotal = $962,037 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	27	6/25/2021	NON-COMPETING CONTINUATION	$962,037
2021	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	26	5/20/2021	COMPETING CONTINUATION	$1
2021	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	25	5/20/2021	NON-COMPETING CONTINUATION	-$1
														Subtotal = $962,037

Issue Date FY: 2020 ( Subtotal = $962,037 )
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	26	9/10/2020	COMPETING CONTINUATION	$962,037
2020	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	25	12/30/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $962,037

Issue Date FY: 2019 ( Subtotal = $773,694 )
2019	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	25	6/21/2019	NON-COMPETING CONTINUATION	$773,694
2019	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	24	2/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $773,694

Issue Date FY: 2018 ( Subtotal = $769,033 )
2018	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	24	6/28/2018	NON-COMPETING CONTINUATION	$769,033
														Subtotal = $769,033

Issue Date FY: 2017 ( Subtotal = $769,180 )
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	23	7/3/2017	NON-COMPETING CONTINUATION	$769,180
														Subtotal = $769,180

Issue Date FY: 2016 ( Subtotal = $902,440 )
2016	2016	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	22	7/15/2016	NON-COMPETING CONTINUATION	$769,789
2016	2016	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	001	22	9/8/2016	SUPPLEMENT FOR EXPANSION	$77,250
2016	2016	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	002	22	9/16/2016	SUPPLEMENT FOR EXPANSION	$55,401
														Subtotal = $902,440

Issue Date FY: 2015 ( Subtotal = $840,417 )
2015	2015	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	002	21	8/24/2015	SUPPLEMENT FOR EXPANSION	$55,401
2015	2015	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	001	21	7/28/2015	COMPETING CONTINUATION	$785,016
2015	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	20	7/27/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $840,417

Issue Date FY: 2014 ( Subtotal = $983,280 )
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	001	20	8/26/2014	SUPPLEMENT FOR EXPANSION	$55,350
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	20	8/1/2014	NON-COMPETING CONTINUATION	$927,930
														Subtotal = $983,280

Issue Date FY: 2013 ( Subtotal = $931,455 )
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	19	7/12/2013	NON-COMPETING CONTINUATION	$876,105
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	001	19	9/20/2013	SUPPLEMENT FOR EXPANSION	$55,350
														Subtotal = $931,455

Issue Date FY: 2012 ( Subtotal = $1,025,466 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	18	7/13/2012	NON-COMPETING CONTINUATION	$945,706
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	002	18	9/5/2012	SUPPLEMENT FOR EXPANSION	$55,350
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	001	18	8/20/2012	SUPPLEMENT FOR EXPANSION	$24,410
														Subtotal = $1,025,466

Issue Date FY: 2011 ( Subtotal = $1,008,562 ) (Continued on the next page)
Grand Total All Awards = $25,614,714

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Nathan Shock Centers of Excellence in Basic Biology of Aging (P30 Clinical Trial Not Allowed)

Award Number: P30AG013280

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/1997

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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