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Female Long-term Adverse Metabolic Effects (FLAME): Inflammatory health outcomes of gestational and type 2 diabetes in reproductive-age women

Award Number: P20GM121301
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Female Long-term Adverse Metabolic Effects (FLAME): Inflammatory health outcomes of gestational and type 2 diabetes in reproductive-age women - Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,951,003 )
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	005	7	8/28/2024	SUPPLEMENT FOR EXPANSION	$42,765
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	004	7	8/27/2024	NON-COMPETING CONTINUATION	$2,580,000
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	006	7	8/29/2024	SUPPLEMENT FOR EXPANSION	$328,238
2024	2023	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	003	6	3/1/2024	COMPETING CONTINUATION	$563,241
2024	2023	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	000	6	2/27/2024	COMPETING CONTINUATION	$0
2024	2021	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	001	5	3/1/2024	NON-COMPETING CONTINUATION	-$507,691
2024	2021	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	002	5	3/1/2024	SUPPLEMENT FOR EXPANSION	-$55,551
														Subtotal = $2,951,003

Issue Date FY: 2023 ( Subtotal = $2,580,000 )
2023	2023	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	6	7/14/2023	COMPETING CONTINUATION	$2,580,000
														Subtotal = $2,580,000

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	001	5	7/15/2022	NON-COMPETING CONTINUATION	$0
2022	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	003	5	9/30/2022	NON-COMPETING CONTINUATION	$0
2022	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	5	11/10/2021	NON-COMPETING CONTINUATION	$0
2022	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	002	5	8/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,524,675 )
2021	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	5	9/1/2021	NON-COMPETING CONTINUATION	$2,275,675
2021	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	001	5	9/7/2021	SUPPLEMENT FOR EXPANSION	$249,000
														Subtotal = $2,524,675

Issue Date FY: 2020 ( Subtotal = $2,730,401 )
2020	2020	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	002	4	8/28/2020	SUPPLEMENT FOR EXPANSION	$429,600
2020	2020	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	001	4	8/25/2020	NON-COMPETING CONTINUATION	$2,300,801
2020	2019	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	3	12/16/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,730,401

Issue Date FY: 2019 ( Subtotal = $2,239,965 )
2019	2019	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	002	3	9/5/2019	NON-COMPETING CONTINUATION	$2,239,965
2019	2018	MAINE MEDICAL CENTER	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	001	2	1/21/2019	NON-COMPETING CONTINUATION	$0
2019	2018	MAINE MEDICAL CENTER	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	2	11/6/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,239,965

Issue Date FY: 2018 ( Subtotal = $2,150,940 )
2018	2018	MAINE MEDICAL CENTER	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	2	9/5/2018	NON-COMPETING CONTINUATION	$2,150,940
														Subtotal = $2,150,940

Issue Date FY: 2017 ( Subtotal = $2,159,876 )
2017	2017	MAINE MEDICAL CENTER	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	1	8/25/2017	NEW	$2,159,876
														Subtotal = $2,159,876

Grand Total All Awards = $17,336,860

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Female Long-term Adverse Metabolic Effects (FLAME): Inflammatory health outcomes of gestational and type 2 diabetes in reproductive-age women

Award Number: P20GM121301

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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