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Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology

Award Number: P01HL141084
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology - PROJECT SUMMARY (OVERALL) The overarching goal of this Program Project Grant (PPG) is to elucidate mechanisms of cardiotoxicity and to develop a platform to test cardiotoxicity of new cancer therapeutics. Project 1 (Moslehi) will use a combination of mouse- and cell-based models to address the central question of whether cardiotoxicity associated with ibrutinib is on- or off-target. Project 2 (Wu) will establish novel pooled “cell villages” from patients to map genetic inter-individual difference in response to kinase inhibitors to elucidate genetic susceptibility to cardiotoxicity from kinase inhibitors. Project 3 (Mercola) aims to identify mechanisms that protect against cardiotoxicity of ibrutinib using a pipeline for discovery of protective targets based on reverting epigenomic consequences of exposure to a toxic drug. All three projects will be supported by an iPSC Processing Core (Core B) (Sallam) that will facilitate a unique repository of iPSC lines from patients with ibrutinib treatment. An Administrative Core (Wu) will support all three projects and the core to facilitate a fully integrated program project and enable high- impact research. The proposed PPG and assembled group collectively introduces synergies that will significantly impact the field of cardio-oncology and make translationally actionable inroads to decrease the burden of adverse effects of cancer therapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	001	6	5/9/2025	COMPETING CONTINUATION	$1,697,034
2025	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	5	5/9/2025	NON-COMPETING CONTINUATION	-$1,697,034
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,415,648 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	001	6	8/21/2024	COMPETING CONTINUATION	$2,415,648
2024	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	5	8/14/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,415,648

Issue Date FY: 2023 ( Subtotal = $2,366,100 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	5	8/9/2023	NON-COMPETING CONTINUATION	$2,366,100
														Subtotal = $2,366,100

Issue Date FY: 2022 ( Subtotal = $2,366,100 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	4	8/5/2022	NON-COMPETING CONTINUATION	$2,366,100
														Subtotal = $2,366,100

Issue Date FY: 2021 ( Subtotal = $2,366,100 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	3	8/18/2021	NON-COMPETING CONTINUATION	$2,366,100
														Subtotal = $2,366,100

Issue Date FY: 2020 ( Subtotal = $2,366,100 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	2	8/28/2020	NON-COMPETING CONTINUATION	$2,366,100
														Subtotal = $2,366,100

Issue Date FY: 2019 ( Subtotal = $2,380,225 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Cardiovascular Diseases Research	000	1	9/1/2019	NEW	$2,380,225
														Subtotal = $2,380,225

Grand Total All Awards = $14,260,273

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Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology

Award Number: P01HL141084

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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