Saturday, February 14, 2026 2/14/2026

Prenatal Programming of Reproductive Health and Disease

Award Number: P01HD044232
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2009
PERIOD OF PERFORMANCE END DATE: 01/31/2018

Group Awards By:

View Award Description

Prenatal Programming of Reproductive Health and Disease - DESCRIPTION (provided by applicant): The susceptibility of the reproductive system to early exposure to steroid hormones has become a major concern in our modern societies. At risk is the fetus whose mother has been exposed to exogenous steroids for a variety of reasons: she has had failed contraception and continued exposure to contraceptive steroids, she is on anabolic steroids, or she is inadvertently being exposed to environmental compounds that have estrogenic or androgenic activity. Experimental manipulation of the prenatal steroid environment provides a powerful investigative tool for unraveling mechanisms that underlie programming of the reproductive axis. Findings from the current funding period found prenatal testosterone (T) excess disrupts the developmental trajectory of the fetus culminating in reproductive neuroendocrine, ovarian, metabolic and behavioral perturbations and implicates ovarian hyperandrogenism and hyperinsulinemia in the development of the pathology. This proposal aims to capitalize on this recently validated sheep model to test a novel, unifying hypothesis for the developmental origins of infertility disorders namely "Hyperinsulinemia and functional hyperandrogenism resulting from metabolic perturbations and/or increased steroid drive to the fetal neuroendocrine-ovarian system plays a key role in prenatal T-induced reproductive dysfunctions". The specific goals of the P01 proposal are to 1) use an insulin-sensitizing agent postnatally to ameliorate hyperinsulinemia and determine if it rescues reproductive function in prenatal T-treated sheep, 2) use an anti-androgen postnatally and determine if it rescues reproductive function in prenatal T-treated sheep, 3) determine if co-treatment with T and an androgen antagonist during fetal life will prevent metabolic and reproductive pathology from developing in the adult, and 4) determine the neuroanatomical, neuroendocrine, ovarian, behavioral and metabolic mechanisms underlying restoration of function. The proposal targets key elements of strategic plans that emanated from workshops convened by the NICHD in 2000-01 "From Cells to Selves" and focuses on the following areas: fetal antecedents of disease, reproductive health for the 21st Century, developmental biology and biobehavioral development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	10	5/24/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	10	1/19/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	Regents of the University of Michigan	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	481091287	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	10	11/9/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $1,121,760 )
2015	2015	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	10	2/3/2015	NON-COMPETING CONTINUATION	$1,121,760
														Subtotal = $1,121,760

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	9	8/4/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $1,443,749 )
2013	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	9	8/8/2013	NON-COMPETING CONTINUATION	$1,443,749
														Subtotal = $1,443,749

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2011	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	000	8	12/7/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $1,511,201 )
2011	2011	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	000	8	8/25/2011	NON-COMPETING CONTINUATION	$1,511,201
														Subtotal = $1,511,201

Issue Date FY: 2010 ( Subtotal = $1,788,445 )
2010	2010	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	004	7	9/13/2010	NON-COMPETING CONTINUATION	$1,666,272
2010	2010	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	6	11/25/2009	SUPPLEMENT FOR EXPANSION	$122,173
2010	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	002	6	1/5/2010	COMPETING CONTINUATION	$0
2010	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	003	6	3/31/2010	COMPETING CONTINUATION	$0
2010	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	001	6	11/25/2009	COMPETING CONTINUATION	$0
														Subtotal = $1,788,445

Issue Date FY: 2009 ( Subtotal = $1,419,279 )
2009	2009	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Population Research	001	6	9/30/2009	COMPETING CONTINUATION	$1,419,279
2009	2008	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	5	9/30/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,419,279

Issue Date FY: 2008 ( Subtotal = $884,501 )
2008	2008	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	5	7/31/2008	NON-COMPETING CONTINUATION	$884,501
														Subtotal = $884,501

Issue Date FY: 2007 ( Subtotal = $1,157,768 )
2007	2007	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	4	8/7/2007	NON-COMPETING CONTINUATION	$1,157,768
														Subtotal = $1,157,768

Issue Date FY: 2006 ( Subtotal = $1,317,337 )
2006	2006	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	3	8/4/2006	NON-COMPETING CONTINUATION	$1,317,337
														Subtotal = $1,317,337

Issue Date FY: 2005 ( Subtotal = $1,312,008 )
2005	2005	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	2	8/8/2005	NON-COMPETING CONTINUATION	$1,312,008
														Subtotal = $1,312,008

Issue Date FY: 2004 ( Subtotal = $959,366 )
2004	2004	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Child Health and Human Development Extramural Research	000	1	7/28/2004	NEW	$959,366
														Subtotal = $959,366

Grand Total All Awards = $12,915,414

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Prenatal Programming of Reproductive Health and Disease

Award Number: P01HD044232

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2009

PERIOD OF PERFORMANCE END DATE: 01/31/2018

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer