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Egg to Embryo: Gene Regulatory Circuitry in Development

Award Number: P01HD037105
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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This is an application for continuation and broadening of a Program Project now in its 9* year. Here we propose to build in many directions on the large success we have had in solving and authenticating a gene regulatory network (GRN) for development. GRNs provide causal explanations for developmental processes in the terms of the genomic regulatory code, where all species-specific developmental processes are ultimately programmed. A developmental GRN serves as a conceptual, system-level logic map, of direct predictive power. Thus GRNs bridge between functional genomic DNA sequence of regulatory significance and the biology of embryogenesis and body plan formation. They do this by specifying the regulatory interactions which causally drive the progression of regulatory states in diverse cellular territories. During recent years, this Program has been responsible for the experimental solution of the most advanced developmental GRN yet available for any developing animal organism. This is the GRN underlying the specification of the endomesodermal territories of the sea urchin embryo. Recently proof of the principle that as a GRN approaches completion it indeed provides explanation of all the observed biological functions has been obtained in this work. We now intend to capitalize on the growing suite of successful technological approaches to GRN analysis that we have developed, to confront challenges that heretofore were inaccessible, or could not even have been defined. The current sea urchin embryo GRN concerns about half of the embryo, that ultimately forming the gut, the skeletogenic cell lineages and the non-skeletogenic mesoderm, from the earliest zygotic genomic activity (at the beginning of cleavage) to just before gastrulation. A start on the oral and aboral ectodermal GRNs has also been made. We intend to expand this GRN in qualitatively distinct ways which will represent radical advances if successful. In the DAVIDSON COMPONENT the GRN will be expanded to include all regulatory genes predicted by genomic analysis, and observed to be expressed specifically in the endomesodermal territories, (cont.)


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$15,035 )
2022	2018	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	20	12/29/2021	NON-COMPETING CONTINUATION	-$15,035
2022	2010	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	000	11	12/29/2021	SUPPLEMENT FOR EXPANSION	$15,035
2022	2010	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	002	11	1/10/2022	SUPPLEMENT FOR EXPANSION	-$15,035
														Subtotal = -$15,035

Issue Date FY: 2021 ( Subtotal = -$189 )
2021	2018	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	20	9/24/2021	NON-COMPETING CONTINUATION	-$189
														Subtotal = -$189

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	20	5/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $1,677,219 )
2018	2018	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	20	5/22/2018	NON-COMPETING CONTINUATION	$1,677,219
														Subtotal = $1,677,219

Issue Date FY: 2017 ( Subtotal = $1,668,501 )
2017	2017	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	19	6/7/2017	NON-COMPETING CONTINUATION	$1,668,501
														Subtotal = $1,668,501

Issue Date FY: 2016 ( Subtotal = $1,643,467 )
2016	2016	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	18	5/27/2016	NON-COMPETING CONTINUATION	$1,643,467
														Subtotal = $1,643,467

Issue Date FY: 2015 ( Subtotal = $1,609,895 )
2015	2015	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	17	5/5/2015	NON-COMPETING CONTINUATION	$1,609,895
														Subtotal = $1,609,895

Issue Date FY: 2014 ( Subtotal = $1,660,082 )
2014	2014	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	16	6/26/2014	COMPETING CONTINUATION	$1,660,082
2014	2013	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	15	6/24/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,660,082

Issue Date FY: 2013 ( Subtotal = $1,542,376 )
2013	2013	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	15	6/10/2013	NON-COMPETING CONTINUATION	$1,542,376
														Subtotal = $1,542,376

Issue Date FY: 2012 ( Subtotal = $1,642,520 )
2012	2012	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	14	5/18/2012	NON-COMPETING CONTINUATION	$1,642,520
														Subtotal = $1,642,520

Issue Date FY: 2011 ( Subtotal = $1,671,579 )
2011	2011	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	13	6/9/2011	NON-COMPETING CONTINUATION	$1,671,579
														Subtotal = $1,671,579

Issue Date FY: 2010 ( Subtotal = $1,732,419 )
2010	2010	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	002	12	6/16/2010	NON-COMPETING CONTINUATION	$1,688,739
2010	2010	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	001	11	4/14/2010	SUPPLEMENT FOR EXPANSION	$8,100
2010	2010	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	11	3/15/2010	SUPPLEMENT FOR EXPANSION	$35,580
2010	2009	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	003	11	9/28/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,732,419

Issue Date FY: 2009 ( Subtotal = $1,811,163 )
2009	2009	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	003	11	9/17/2009	SUPPLEMENT FOR EXPANSION	$219,751
2009	2009	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	11	5/21/2009	COMPETING CONTINUATION	$1,583,372
2009	2009	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	002	11	7/10/2009	SUPPLEMENT FOR EXPANSION	$8,040
2009	2008	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	10	5/21/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,811,163

Issue Date FY: 2008 ( Subtotal = $1,229,721 )
2008	2008	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	10	3/6/2008	NON-COMPETING CONTINUATION	$1,229,721
														Subtotal = $1,229,721

Issue Date FY: 2007 ( Subtotal = $1,218,499 )
2007	2007	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	9	3/10/2007	NON-COMPETING CONTINUATION	$1,218,499
														Subtotal = $1,218,499

Issue Date FY: 2006 ( Subtotal = $1,218,581 )
2006	2006	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	8	3/18/2006	NON-COMPETING CONTINUATION	$1,218,581
														Subtotal = $1,218,581

Issue Date FY: 2005 ( Subtotal = $1,211,806 )
2005	2005	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	7	3/15/2005	NON-COMPETING CONTINUATION	$1,211,806
														Subtotal = $1,211,806

Issue Date FY: 2004 ( Subtotal = $1,209,643 )
2004	2004	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	6	1/23/2004	COMPETING CONTINUATION	$1,209,643
														Subtotal = $1,209,643

Issue Date FY: 2003 ( Subtotal = $1,133,590 )
2003	2003	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Population Research	000	5		NON-COMPETING CONTINUATION	$1,133,590
														Subtotal = $1,133,590

Issue Date FY: 2002 ( Subtotal = $1,100,527 )
2002	2002	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Population Research	000	4	3/28/2002	NON-COMPETING CONTINUATION	$1,100,527
														Subtotal = $1,100,527

Issue Date FY: 2001 ( Subtotal = $1,070,777 ) (Continued on the next page)
Grand Total All Awards = $28,100,678

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Egg to Embryo: Gene Regulatory Circuitry in Development

Award Number: P01HD037105

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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