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Bone Marrow Grafting and Cellular Therapy for Leukemia and Lymphoma

Award Number: P01CA049605
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/1997
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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Bone Marrow Grafting and Cellular Therapy for Leukemia and Lymphoma - Overall Program Project Grant: Project Summary/Abstract Hematopoietic cell transplantation (HCT) is an effective therapy for a broad range of hematological malignances and represents the first successful, widely applied cellular therapy for cancer. The mechanisms of improved outcomes are focused on hematopoietic and immunological engraftment from the donor to the recipient, resulting in graft vs tumor effects and immunological reconstitution. However, several major challenges remain, including immunological recognition and attack of the host termed graft vs host disease (GVHD), immunological incompetence resulting in frequent opportunistic infections, reactivation of endogenous viruses and disease relapse. We have made excellent progress in the prior funding period as detailed in the application. The overall goals of our Program Project Grant are to develop a more robust fundamental understanding of transplantation biology and address the major challenges of HCT including GVHD, disease relapse and immune reconstitution. We will tackle these major challenges through innovative animal modeling, comprehensive biological and molecular analysis, novel imaging of animal and human subjects and biologically focused translational clinical trials. In addition, we will explore the biology of key cellular populations including Treg, iNKT, TR1, CD8 memory and CAR T cells. Our Program involves 5 interactive Projects focusing on the biology and prevention of GVHD through an enhanced understanding of cellular imaging and immune regulation (Projects 1 and 2), prevention and treatment of disease relapse with memory CD8+ T cells and vaccination strategies (Project 3), improved function and efficacy of CAR T cells (Project 4) and monoclonal antibody based strategies (Project 5). These Projects are supported by three Cores (Administration and Clinical Trial Coordination, Biostatistics and Data Management and Cell Processing and Immune Monitoring). Through our interactive Program Project, we will gain novel insights into the biology of hematopoietic cell transplantation and develop innovative strategies to improve outcomes for patients with hematological malignancies. The knowledge gained has profound implications for cancer and transplantation biology and also for the treatment of patients with a broad range of immunological conditions such as autoimmune disorders and transplantation of solid organs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $2,735,488 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	33	9/8/2023	NON-COMPETING CONTINUATION	$2,735,488
														Subtotal = $2,735,488

Issue Date FY: 2022 ( Subtotal = $2,680,780 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	001	32	9/15/2022	NON-COMPETING CONTINUATION	$0
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	32	9/7/2022	NON-COMPETING CONTINUATION	$2,680,780
														Subtotal = $2,680,780

Issue Date FY: 2021 ( Subtotal = $2,735,492 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	001	31	8/25/2021	NON-COMPETING CONTINUATION	$2,735,488
2021	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	29	12/3/2020	COMPETING CONTINUATION	$4
														Subtotal = $2,735,492

Issue Date FY: 2020 ( Subtotal = $2,739,423 )
2020	2020	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	30	8/19/2020	NON-COMPETING CONTINUATION	$2,739,423
														Subtotal = $2,739,423

Issue Date FY: 2019 ( Subtotal = $2,745,880 )
2019	2019	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	001	29	9/16/2019	COMPETING CONTINUATION	$2,745,884
2019	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	28	7/24/2019	NON-COMPETING CONTINUATION	-$4
														Subtotal = $2,745,880

Issue Date FY: 2017 ( Subtotal = $2,700,000 )
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	28	3/21/2017	NON-COMPETING CONTINUATION	$2,430,000
2017	2017	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	001	28	6/7/2017	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $2,700,000

Issue Date FY: 2016 ( Subtotal = $2,700,000 )
2016	2016	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	27	4/4/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,700,000
														Subtotal = $2,700,000

Issue Date FY: 2015 ( Subtotal = $2,700,000 )
2015	2015	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	26	5/19/2015	NON-COMPETING CONTINUATION	$2,700,000
														Subtotal = $2,700,000

Issue Date FY: 2014 ( Subtotal = $2,619,001 )
2014	2014	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	25	5/14/2014	NON-COMPETING CONTINUATION	$2,619,001
														Subtotal = $2,619,001

Issue Date FY: 2013 ( Subtotal = $2,700,000 )
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	24	6/3/2013	COMPETING CONTINUATION	$1,350,000
2013	2013	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	001	24	7/5/2013	COMPETING CONTINUATION	$1,350,000
														Subtotal = $2,700,000

Issue Date FY: 2011 ( Subtotal = $3,462,150 )
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	001	23	5/17/2011	NON-COMPETING CONTINUATION	$153,476
2011	2011	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	23	4/22/2011	NON-COMPETING CONTINUATION	$3,308,674
														Subtotal = $3,462,150

Issue Date FY: 2010 ( Subtotal = $3,583,412 )
2010	2010	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	22	6/4/2010	NON-COMPETING CONTINUATION	$3,583,412
														Subtotal = $3,583,412

Issue Date FY: 2009 ( Subtotal = $3,525,298 )
2009	2009	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	21	3/23/2009	NON-COMPETING CONTINUATION	$3,525,298
														Subtotal = $3,525,298

Issue Date FY: 2008 ( Subtotal = $3,446,067 )
2008	2008	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	20	4/16/2008	NON-COMPETING CONTINUATION	$3,446,067
														Subtotal = $3,446,067

Issue Date FY: 2007 ( Subtotal = $3,353,514 )
2007	2007	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	19	4/5/2007	COMPETING CONTINUATION	$3,353,514
														Subtotal = $3,353,514

Issue Date FY: 2006 ( Subtotal = $3,175,580 )
2006	2006	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	18	4/4/2006	NON-COMPETING CONTINUATION	$3,175,580
														Subtotal = $3,175,580

Issue Date FY: 2005 ( Subtotal = $3,165,316 )
2005	2005	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	17	2/22/2005	NON-COMPETING CONTINUATION	$3,165,316
														Subtotal = $3,165,316

Issue Date FY: 2004 ( Subtotal = $3,062,251 )
2004	2004	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	16	3/9/2004	NON-COMPETING CONTINUATION	$3,062,251
														Subtotal = $3,062,251

Issue Date FY: 2003 ( Subtotal = $2,683,519 )
2003	2003	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	15		NON-COMPETING CONTINUATION	$2,683,519
														Subtotal = $2,683,519

Issue Date FY: 2002 ( Subtotal = $2,884,418 )
2002	2002	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	14	8/21/2002	COMPETING CONTINUATION	$2,884,418
														Subtotal = $2,884,418

Issue Date FY: 2001 ( Subtotal = $2,582,252 )
2001	2001	STANFORD UNIVERSITY	651 SERRA STREET, ROOM 110	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	13	3/8/2001	NON-COMPETING CONTINUATION	$2,582,252
														Subtotal = $2,582,252

Issue Date FY: 2000 ( Subtotal = $2,514,104 ) (Continued on the next page)
2000	2000	STANFORD UNIVERSITY	450 SERRA MALL	STANFORD	CA	94305	SANTA CLARA	USA	Cancer Treatment Research	000	12	3/13/2000	NON-COMPETING CONTINUATION	$2,355,342
Grand Total All Awards = $68,954,617

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Bone Marrow Grafting and Cellular Therapy for Leukemia and Lymphoma

Award Number: P01CA049605

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/1997

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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