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Molecular Biology and Genetics of Human Tumor Viruses

Award Number: P01CA022443
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/1997
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Molecular Biology and Genetics of Human Tumor Viruses - OVERALL – PROJECT SUMMARY/ABSTRACT Molecular Biology and Genetics of Human Tumor Viruses Paul F. Lambert, PI Viruses cause approximately 15% of human cancers. A viral etiology to a human cancer can have substantive consequences on its treatment and prevention. For example, many virally-caused human cancers express virally encoded products, which are potential targets for anti-viral, tumor-specific therapies. In addition, unique sets of cellular genes and pathways contribute to virally-associated cancers, many of which are currently being pursued as targets for anti-cancer therapies. This program project grant (PPG), now in its 45th year of continual funding, has two major objectives: to use molecular biology and genetics to elucidate the life cycles of and transformation by human tumor viruses and to translate this understanding into the identification of targets for specific anti-viral, anti-tumor therapies. The PPG has seven lead investigators who share these research goals in studying multiple human tumor viruses in two different virus families: papillomaviruses, and herpesviruses. Together, these viruses cause the vast majority of virally-associated human cancers. The PPG has been highly productive over the current funding period with 88 studies published of which 33% involve two or more labs, reflecting on the strong synergies arising from the PPG. Our PPG has a unique organization in which each of four projects have two or more labs working together on a common theme in human tumor virology. Cross-fertilization of ideas and expertise between projects is fostered by having many of the seven investigators participating in multiple projects. This interactive and collaborative organization has been highly fruitful over the current funding period in several regards. Firstly, each project has been productive and has collaborated with other projects. Secondly, innovative new ideas and approaches have arisen, many of which are now being used across multiple projects. Thirdly, the collaborative environment created by this PPG has spawned new interactions that have brought additional expertise to the PPG. The specific themes of this PPG are: 1) Characterize the Mechanism by Which Papillomaviruses Evade Host Immunity; 2) Uncovering Mechanisms of the Lymphoid Oncogenesis of Epstein-Barr Virus and Kaposi’s Sarcoma Herpesvirus; 3) Latent and Lytic EBV Infection in Epithelial Cells; and 4) Defining the Role of EBV in DLBCL Pathogenesis and Identification of Therapeutic Targets. Three cores provide expertise in A) administration, statistics and bioinformatics, B) instrumentation, microscopy and histology, and C) virus engineering and production.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,069,205 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	002	47	4/15/2025	NON-COMPETING CONTINUATION	$2,069,205
2025	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	46	2/24/2025	COMPETING CONTINUATION	$3,494
2025	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	001	45	2/24/2025	SUPPLEMENT FOR EXPANSION	-$3,494
														Subtotal = $2,069,205

Issue Date FY: 2024 ( Subtotal = $2,069,205 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	001	46	3/21/2024	COMPETING CONTINUATION	$2,069,205
2024	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	45	3/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,069,205

Issue Date FY: 2023 ( Subtotal = $500,000 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	45	9/13/2023	SUPPLEMENT FOR EXPANSION	$500,000
														Subtotal = $500,000

Issue Date FY: 2022 ( Subtotal = $2,328,810 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	45	9/13/2022	NON-COMPETING CONTINUATION	$56,169
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	45	5/3/2022	NON-COMPETING CONTINUATION	$2,272,641
														Subtotal = $2,328,810

Issue Date FY: 2021 ( Subtotal = $2,345,231 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	44	5/31/2021	NON-COMPETING CONTINUATION	$2,272,641
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	001	44	6/9/2021	SUPPLEMENT FOR EXPANSION	$72,590
														Subtotal = $2,345,231

Issue Date FY: 2020 ( Subtotal = $2,421,081 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	003	43	9/1/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	002	43	8/11/2020	SUPPLEMENT FOR EXPANSION	$75,850
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	43	4/24/2020	NON-COMPETING CONTINUATION	$2,345,231
2020	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	000	42	11/14/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,421,081

Issue Date FY: 2019 ( Subtotal = $2,271,489 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Biology Research	003	42	7/29/2019	SUPPLEMENT FOR EXPANSION	$67,026
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	42	4/30/2019	NON-COMPETING CONTINUATION	$2,204,463
2019	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	41	12/21/2018	COMPETING CONTINUATION	$1,352
2019	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	40	12/21/2018	NON-COMPETING CONTINUATION	-$1,352
														Subtotal = $2,271,489

Issue Date FY: 2018 ( Subtotal = $2,272,641 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	004	41	9/17/2018	COMPETING CONTINUATION	$243,580
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	41	4/5/2018	COMPETING CONTINUATION	$2,272,641
2018	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	003	40	9/17/2018	NON-COMPETING CONTINUATION	-$243,580
2018	2016	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	39	1/11/2018	EXTENSION WITH OR WITHOUT FUNDS	$487
2018	2015	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	38	1/11/2018	NON-COMPETING CONTINUATION	-$487
														Subtotal = $2,272,641

Issue Date FY: 2017 ( Subtotal = $2,063,652 )
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	40	4/27/2017	NON-COMPETING CONTINUATION	$1,857,287
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	40	6/7/2017	NON-COMPETING CONTINUATION	$206,365
														Subtotal = $2,063,652

Issue Date FY: 2016 ( Subtotal = $2,063,652 )
2016	2016	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	39	4/20/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,063,652
														Subtotal = $2,063,652

Issue Date FY: 2015 ( Subtotal = $2,078,646 )
2015	2015	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	38	4/22/2015	NON-COMPETING CONTINUATION	$2,078,646
														Subtotal = $2,078,646

Issue Date FY: 2014 ( Subtotal = $2,532,651 )
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	37	5/6/2014	NON-COMPETING CONTINUATION	$2,001,744
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	37	9/11/2014	NON-COMPETING CONTINUATION	$14,994
2014	2013	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	36	3/13/2014	COMPETING CONTINUATION	$515,913
														Subtotal = $2,532,651

Issue Date FY: 2013 ( Subtotal = $2,063,652 )
2013	2013	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	36	3/13/2014	COMPETING CONTINUATION	$515,913
2013	2013	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	36	8/5/2013	COMPETING CONTINUATION	$0
2013	2013	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	36	6/6/2013	COMPETING CONTINUATION	$1,547,739
														Subtotal = $2,063,652

Issue Date FY: 2012 ( Subtotal = $1,850,672 )
2012	2012	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	35	8/8/2012	NON-COMPETING CONTINUATION	$1,850,672
														Subtotal = $1,850,672

Issue Date FY: 2011 ( Subtotal = $1,858,213 ) (Continued on the next page)
2011	2011	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	34	6/15/2011	NON-COMPETING CONTINUATION	$82,374
Grand Total All Awards = $51,952,862

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Molecular Biology and Genetics of Human Tumor Viruses

Award Number: P01CA022443

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/1997

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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