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Targeting Transcription and Splicing in Cancer

Award Number: P01CA013106
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Targeting Transcription and Splicing in Cancer - OVERALL PROJECT SUMMARY The overall goal of this Program is to understand how transcription and splicing regulation is altered and co- opted by cancer cells to promote tumor initiation and progression, and to apply this knowledge towards development of new therapeutic approaches. During the past 50 years, the strong underlying basic science foundation of the Program Project has allowed members to identify vulnerabilities in cancer and develop novel and highly specific therapeutic strategies. This Program continues to take a multi-pronged approach grounded in basic cancer research to identify and disrupt the molecular dependencies underlying cancer. Within this Program, there are three highly integrated Projects (Targeting oncogenic transcription factors; RNA Splicing dysregulation in cancer; Regulatory RNAs as cancer drivers and dependencies) and four innovative Cores that are using cutting edge technologies to study the molecular mechanisms of cancer biology. To achieve the Program's goals, these studies will exploit novel organoid models of human cancers, pioneering imaging modalities in animal models, therapeutic antisense oligonucleotide strategies against otherwise undruggable targets, and cutting-edge methods in biochemistry, cell biology and molecular biology. The researchers will interrogate the basis of two of the most devastating types of tumors, basal-like carcinomas of the breast and pancreas. All of this work is supported by four Cores that provide access to technologies, services, and expertise that all combine to enhance productivity and promote interactions. The interactive and collaborative nature of this Program guides each of these Projects beyond their singular potential. Research in all three Projects touches on overlapping themes and benefits from the expertise of the other Program members. Together, this Program is making significant progress towards its goal of identifying novel therapeutic targets that will substantially impact cancer treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,592,001 )
2025	2025	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	53	2/28/2025	NON-COMPETING CONTINUATION	$2,592,001
														Subtotal = $2,592,001

Issue Date FY: 2024 ( Subtotal = $2,735,999 )
2024	2024	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Cancer Biology Research	003	52	4/16/2024	NON-COMPETING CONTINUATION	$143,998
2024	2024	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	002	52	3/5/2024	NON-COMPETING CONTINUATION	$2,592,001
2024	2023	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Cancer Biology Research	001	51	3/1/2024	COMPETING CONTINUATION	$424,776
2024	2022	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPG HBR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	50	3/1/2024	NON-COMPETING CONTINUATION	-$424,776
														Subtotal = $2,735,999

Issue Date FY: 2023 ( Subtotal = $2,880,000 )
2023	2023	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	51	2/1/2023	COMPETING CONTINUATION	$2,880,000
														Subtotal = $2,880,000

Issue Date FY: 2022 ( Subtotal = $4,384,609 )
2022	2022	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	001	50	5/24/2022	NON-COMPETING CONTINUATION	$357,932
2022	2022	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	50	2/1/2022	NON-COMPETING CONTINUATION	$4,026,677
														Subtotal = $4,384,609

Issue Date FY: 2021 ( Subtotal = $4,484,444 )
2021	2021	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	49	1/18/2021	NON-COMPETING CONTINUATION	$4,484,444
														Subtotal = $4,484,444

Issue Date FY: 2020 ( Subtotal = $4,483,547 )
2020	2020	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	48	1/30/2020	NON-COMPETING CONTINUATION	$4,483,547
														Subtotal = $4,483,547

Issue Date FY: 2019 ( Subtotal = $4,344,544 )
2019	2019	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	47	1/18/2019	NON-COMPETING CONTINUATION	$4,344,544
														Subtotal = $4,344,544

Issue Date FY: 2018 ( Subtotal = $4,537,433 )
2018	2018	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	46	2/20/2018	COMPETING CONTINUATION	$4,537,433
2018	2017	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	001	45	5/1/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,537,433

Issue Date FY: 2017 ( Subtotal = $2,165,000 )
2017	2017	COLD SPRING HARBOR LABORATORY	1 BUNGTOWN RD	COLD SPRING HARBOR	NY	11724	SUFFOLK	USA	Cancer Biology Research	000	45	3/22/2017	SUPPLEMENT FOR EXPANSION	$2,165,000
														Subtotal = $2,165,000

Issue Date FY: 2016 ( Subtotal = $4,445,418 )
2016	2016	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	002	45	5/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$24,150
2016	2016	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	45	2/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$442,126
2016	2016	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	45	12/1/2015	EXTENSION WITH OR WITHOUT FUNDS	$3,979,142
														Subtotal = $4,445,418

Issue Date FY: 2015 ( Subtotal = $4,421,268 )
2015	2015	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	44	12/30/2014	NON-COMPETING CONTINUATION	$3,979,142
2015	2015	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	44	1/29/2015	NON-COMPETING CONTINUATION	$329,523
2015	2015	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	002	44	2/24/2015	NON-COMPETING CONTINUATION	$112,603
														Subtotal = $4,421,268

Issue Date FY: 2014 ( Subtotal = $4,221,622 )
2014	2014	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	43	4/17/2014	NON-COMPETING CONTINUATION	$304,654
2014	2014	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	43	12/31/2013	NON-COMPETING CONTINUATION	$3,916,968
														Subtotal = $4,221,622

Issue Date FY: 2013 ( Subtotal = $4,101,060 )
2013	2013	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	42	2/13/2013	NON-COMPETING CONTINUATION	$2,176,095
2013	2013	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	42	6/10/2013	NON-COMPETING CONTINUATION	$1,924,965
														Subtotal = $4,101,060

Issue Date FY: 2012 ( Subtotal = $4,486,042 )
2012	2012	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	002	41	9/21/2012	SUPPLEMENT FOR EXPANSION	$188,000
2012	2012	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	41	5/25/2012	COMPETING CONTINUATION	$4,298,042
2012	2011	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	40	5/22/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,486,042

Issue Date FY: 2011 ( Subtotal = $4,592,515 )
2011	2011	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	40	5/27/2011	NON-COMPETING CONTINUATION	$203,584
2011	2011	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	40	12/29/2010	NON-COMPETING CONTINUATION	$4,388,931
														Subtotal = $4,592,515

Issue Date FY: 2010 ( Subtotal = $5,193,446 )
2010	2010	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	003	39	1/27/2010	NON-COMPETING CONTINUATION	$4,743,330
2010	2009	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	001	38	10/22/2009	NON-COMPETING CONTINUATION	$0
2010	2009	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Trans-NIH Recovery Act Research Support	002	38	12/10/2009	SUPPLEMENT FOR EXPANSION	$0
2010	2009	COLD SPRING HARBOR LABORATORY	BUNGTOWN ROAD	COLD SPRING HRBR	NY	11724		USA	Cancer Biology Research	000	38	10/22/2009	NON-COMPETING CONTINUATION	$450,116
														Subtotal = $5,193,446

Issue Date FY: 2009 ( Subtotal = $4,600,470 ) (Continued on the next page)
Grand Total All Awards = $119,282,396

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Targeting Transcription and Splicing in Cancer

Award Number: P01CA013106

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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