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MOLECULAR MECHANISMS OF SKELETAL REPAIR

Award Number: P01AR049920
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2004
PERIOD OF PERFORMANCE END DATE: 05/31/2009

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MOLECULAR MECHANISMS OF SKELETAL REPAIR - DESCRIPTION (provided by applicant): Skeletal repair is a fundamental process that underlies many aspects of orthopaedic and musculoskeletal care ranging from fracture treatment to reconstructive surgery of the spine and extremities. Current estimates indicate that 5-10% of fractures experience delayed or impaired healing, 5-30% of spinal fusions fail to unite and the number of bone graft procedures performed worldwide exceeds 1.5 million per year. Thus while much has been learned regarding the biology of the bone repair process, significant gaps remain in our knowledge and a need exists for the development of strategies to enhance skeletal healing and regeneration. This application will cover areas of cell and molecular biology, biomedical engineering, and metabolic bone disease to provide a coordinated, integrated program of investigations on skeletal repair. Scientists with expertise in each of these domains will interact for the mutual gain of knowledge and synergistic development of concepts and ideas. The scientific program is composed of 3 projects and 4 cores. The projects will elucidate the mechanisms of angiogenesis in bone regeneration using a model of distraction osteogenesis, the role of BMPs in fracture healing using a novel transgenic model in which small-molecule-regulated protein dimerization is used to specifically activate a transcription factor that allows us to express noggin (an inhibitor of BMP function) or BMP2 in both in a conditional and tissue specific manner, and the effects of metabolic dysregulation on fracture healing using diabetes as a model system. The cores will provide services and databases to enhance the development of the projects. The genomics and informatics core will enhance the collection, organization and sharing of data among projects. A centralized facility for carrying out standardized measurements of skeletal healing will be established through the histomorphometry and biomechanics core. The cellular and molecular biology core will provide a centralized facility for the development and maintenance of the cellular and molecular biological reagents as well insure uniform quality control for all our surgical models. Finally, oversight and management of programmatic directives and funds and coordination of advisory input from the internal and external committees will be provided through the administrative core. The program intends to establish a more profound understanding of skeletal repair mechanisms through the integrative and collaborative activities of a team of investigators who have a track record of complimentary and synergistic scientific associations. Successful establishment and implementation of this program will greatly enhance the coordinated activities of this team of investigators and lead to important new results and directions for skeletal healing research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $1,062,436 )
2008	2008	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	5/30/2008	NON-COMPETING CONTINUATION	$1,062,436
														Subtotal = $1,062,436

Issue Date FY: 2007 ( Subtotal = $1,053,210 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	5/31/2007	NON-COMPETING CONTINUATION	$1,053,210
														Subtotal = $1,053,210

Issue Date FY: 2006 ( Subtotal = $1,053,750 )
2006	2006	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/1/2006	NON-COMPETING CONTINUATION	$1,053,750
														Subtotal = $1,053,750

Issue Date FY: 2005 ( Subtotal = $1,094,905 )
2005	2005	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	5/27/2005	NON-COMPETING CONTINUATION	$1,094,905
														Subtotal = $1,094,905

Issue Date FY: 2004 ( Subtotal = $1,101,602 )
2004	2004	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	6/7/2004	NEW	$1,101,602
														Subtotal = $1,101,602

Grand Total All Awards = $5,365,903

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MOLECULAR MECHANISMS OF SKELETAL REPAIR

Award Number: P01AR049920

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2004

PERIOD OF PERFORMANCE END DATE: 05/31/2009

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