Friday, October 10, 2025 10/10/2025

Learning from Remission and Relapse in SLE

Award Number: P01AI172523
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Learning from Remission and Relapse in SLE - Abstract – Overview This program project is an exploration of patients with Systemic Lupus Erythematosus who are in long term clinical remission on no corticosteroid or immunosuppressive medication. We will study blood immune cells at the single cell level exploring distribution of cellular subsets and transcriptional, epigenetic and proteomic profiles, as well as the repertoire of naive and memory B cells reactive with nuclear antigens. We will explore brain function in these patients to determine if there is ongoing inflammation in the central nervous system in some patients despite a lack of inflammation in the periphery. Given the now recognized interplay of the immune system and the brain, we will seek correlations between immune cell profile and brain function. As approximately 25% of patients in remission can be expected to relapse over 5 years, we will seek predictors of relapse. These studies should teach us about patient heterogeneity, novel states of immune or brain homeostasis, and predictors of sustained remission or flare.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,902,476 )
2025	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Allergy and Infectious Diseases Research	000	2	8/28/2025	NON-COMPETING CONTINUATION	$2,678,601
2025	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Allergy and Infectious Diseases Research	002	2	9/11/2025	SUPPLEMENT FOR EXPANSION	$90,908
2025	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Allergy and Infectious Diseases Research	001	2	9/10/2025	SUPPLEMENT FOR EXPANSION	$132,967
														Subtotal = $2,902,476

Issue Date FY: 2024 ( Subtotal = $2,902,477 )
2024	2024	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Allergy and Infectious Diseases Research	000	1	5/9/2024	NEW	$2,902,477
														Subtotal = $2,902,477

Grand Total All Awards = $5,804,953

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Learning from Remission and Relapse in SLE

Award Number: P01AI172523

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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