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Microbiota and Allergic Asthma Precision Prevention (MAAP2)

Award Number: P01AI089473
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/06/2012
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Microbiota and Allergic Asthma Precision Prevention (MAAP2) - This application builds on the findings of our initial P01 designed to examine relationships between environmental factors, especially pets, the infant gut microbiota and pediatric allergic asthma. We have shown that: 1) dogs alter the microbial composition of dust in homes, 2) children born into homes with dogs have different developmental patterns of gut microbiota and of IgE, 3) a distinct pattern of gut microbial composition at 1 month of age is related to heightened risk of sensitization to multiple allergens at 2 years and of asthma at 4 years, and this pattern is influenced by numerous maternal characteristics, 4) sensitization to multiple food and inhalant allergens at 2 years is strongly related to asthma at 10 years, 5) the metabolic profiles of stools are related to later allergic sensitization 6) 12,13-DiHOME, a metabolite in stool, promotes development of Th2 lymphocytes and lowers development of Treg lymphocytes in an in vitro assay, and 7) in another study, the meconial microbiota is distinct in neonates born to mothers with asthma. Our complementary mouse studies have shown that: 1) gavaging with dust from homes with dogs reduces lung inflammation from allergen sensitization and from respiratory syncytial virus (RSV) infection, 2) dog dust gavaged mice have increases in Lactobacillus johnsonii in their ceca 3) oral administration of live L. johnsonii confers protection against pulmonary inflammation induced by allergen and RSV, 4) L. johnsonii alters the function of bone marrow- derived dendritic cells, 5) mice orally supplemented with L. johnsonii have altered serum metabolic profiles, and 6) mouse pups born to L. johnsonii-supplemented mothers are protected against allergen challenge and RSV infection. Collectively these findings showing the influence of maternal factors provide the basis for this application's focus on the maternal gut and vaginal microbiotas during pregnancy, and how these relate to infant gut microbial development and risk of allergic asthma. Project 1 focuses on the relationship of maternal environmental and dietary factors, including maternal and infant gut microbiotas, to the child's developing a high-risk for asthma phenotype by age 2 years. Project 2 proposes a detailed examination of relationships between maternal and child microbiota, breast milk composition and IgE development amongst a cohort of pregnancies in which the mother has current allergic asthma. Project 3 synergistically interacts with Projects 1 & 2 and also uses specimens from 10-year-old allergic asthma cases and controls in the initial P01 birth cohort to examine gut microbes producing metabolites associated with a lowered risk of allergic inflammation and how they are transferred from mother and established in offspring. Project 4 will use mouse models to examine the relationships between manipulation of maternal microbiota and immune development in offspring. We anticipate that together these studies will show that interventions directed at the gut microbiota of mothers during pregnancy and of high-risk neonates after birth could reduce the risk of allergic asthma in childhood. Such findings would provide the foundations of a rational strategy to prevent allergic asthma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	10	7/3/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,818,591 )
2024	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	10	8/9/2024	NON-COMPETING CONTINUATION	$2,818,591
														Subtotal = $2,818,591

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	9	8/21/2023	NON-COMPETING CONTINUATION	$0
2023	2022	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	9	7/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,994,595 )
2022	2022	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	9	8/22/2022	NON-COMPETING CONTINUATION	$2,994,595
2022	2020	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	7	4/19/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,994,595

Issue Date FY: 2021 ( Subtotal = $2,972,338 )
2021	2021	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	8	9/2/2021	NON-COMPETING CONTINUATION	$2,972,338
														Subtotal = $2,972,338

Issue Date FY: 2020 ( Subtotal = $3,140,814 )
2020	2020	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	004	7	9/25/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	003	7	8/11/2020	SUPPLEMENT FOR EXPANSION	$65,682
2020	2020	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	002	7	8/7/2020	NON-COMPETING CONTINUATION	$2,940,814
2020	2020	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	6	5/18/2020	SUPPLEMENT FOR EXPANSION	$134,318
2020	2016	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	5	3/23/2020	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $3,140,814

Issue Date FY: 2019 ( Subtotal = $2,859,652 )
2019	2019	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	6	9/5/2019	COMPETING CONTINUATION	$2,859,652
														Subtotal = $2,859,652

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	5	6/22/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2016	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	5	6/21/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $330,605 )
2017	2017	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	002	5	8/18/2017	SUPPLEMENT FOR EXPANSION	$330,605
2017	2016	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	5	1/25/2017	EXTENSION WITH OR WITHOUT FUNDS	$699,396
2017	2015	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	4	1/25/2017	NON-COMPETING CONTINUATION	-$699,396
														Subtotal = $330,605

Issue Date FY: 2016 ( Subtotal = $1,695,940 )
2016	2016	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	5	7/5/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,695,940
														Subtotal = $1,695,940

Issue Date FY: 2015 ( Subtotal = $2,124,181 )
2015	2015	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	4	8/28/2015	NON-COMPETING CONTINUATION	$249,465
2015	2015	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	4	6/12/2015	NON-COMPETING CONTINUATION	$1,874,716
														Subtotal = $2,124,181

Issue Date FY: 2014 ( Subtotal = $3,176,077 )
2014	2014	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	001	3	8/22/2014	NON-COMPETING CONTINUATION	$1,295,706
2014	2014	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	3	6/27/2014	NON-COMPETING CONTINUATION	$1,880,371
														Subtotal = $3,176,077

Issue Date FY: 2013 ( Subtotal = $1,753,575 )
2013	2013	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	2	6/10/2013	NON-COMPETING CONTINUATION	$1,753,575
														Subtotal = $1,753,575

Issue Date FY: 2012 ( Subtotal = $1,792,707 )
2012	2012	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Allergy and Infectious Diseases Research	000	1	7/6/2012	NEW	$1,792,707
														Subtotal = $1,792,707

Grand Total All Awards = $25,659,075

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Microbiota and Allergic Asthma Precision Prevention (MAAP2)

Award Number: P01AI089473

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/06/2012

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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