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Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI)

Award Number: P01AG041710
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2013
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) - Overall—Abstract Adults in South Africa are surviving to older ages, yet the burden and risk factors of aging-related diseases, particularly dementia and Alzheimer’s disease, remains poorly defined. By 2050, more than 75% of global dementia cases are projected to occur in low- and middle-income countries (LMICs). The proposed renewal of the Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) Program includes four tightly integrated projects supported by three cores that together will reveal interrelationships among common chronic diseases and other risk factors of cognitive impairment and dementia in South Africa. Each project rests on a common platform of individual surveys, cognitive assessments, biomarker collection, and mortality ascertainment, with additional measures specific to each project. In previous funding cycles (2014-2022), we successfully collected three waves of HAALSI Agincourt data in 5059 participants ≥40 years of age, achieving response rates of 86-94% among living cohort members. We also collected two waves of data under the Harmonized Cognitive Assessment Protocol (HCAP) at 3-year intervals. For this renewal application, the HAALSI Program will continue following the HAALSI Agincourt cohort (Aim 1), including original enrollees and a refresher sample of 1898, 40- to 49-year-olds, for a total of 13 years of longitudinal data. We will conduct a third HCAP wave on a subsample of the HAALSI Agincourt cohort, with expanded biomarker, neuroimaging, and clinical assessments to understand interactions among cognitive impairment/dementia, HIV infection, and cardiometabolic disorders (CMDs). In Aim 2, we will identify biological, social, and economic predictors of mortality and dementia, and assess disease incidence and changes in physical and cognitive function in the HAALSI Agincourt cohort. In addition, in Aim 3, we will pilot and launch a nationally representative cohort study of 4500 people ≥40 years of age and their partners (approximately 7200 total) using approaches from the HAALSI Agincourt survey; of these, approximately 624 will also undergo the HCAP. The HAALSI National survey will enable us to estimate the prevalence of dementia and other aging-related conditions, and their cross-sectional associations with social and economic, behavioral, and health utilization exposures. We will use innovative transportability methods to assess the alignment of diseases in the rural Agincourt county with the national level. In Aim 4, we will evaluate the health impacts of public health and social policies developed to improve healthy aging, specifically those aimed at reducing salt intake, and increasing financial security of older adults and families. Finally, in Aim 5, we will maximize collaborations with HRS sister studies, H3Africa and DS-I Africa projects, enabling cross-country comparisons and studies at the level of population genetics. Together, the HAALSI Program will produce valuable insights into the burden and drivers of dementia and other aging-related diseases which inform the development of effective United States health policies to ensure healthy aging and wellbeing of aging populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $5,899,956 )
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	002	12	6/23/2026	SUPPLEMENT FOR EXPANSION	$6,385
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	001	12	6/23/2026	SUPPLEMENT FOR EXPANSION	$1,300,148
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	000	12	6/11/2026	NON-COMPETING CONTINUATION	$3,008,844
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	003	12	6/24/2026	SUPPLEMENT FOR EXPANSION	$1,584,579
														Subtotal = $5,899,956

Issue Date FY: 2025 ( Subtotal = $6,202,076 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	002	11	9/12/2025	SUPPLEMENT FOR EXPANSION	$2,439,585
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	001	11	8/28/2025	SUPPLEMENT FOR EXPANSION	$1,334,268
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	003	11	9/15/2025	SUPPLEMENT FOR EXPANSION	$175,441
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Aging Research	000	11	8/22/2025	NON-COMPETING CONTINUATION	$2,252,782
														Subtotal = $6,202,076

Issue Date FY: 2024 ( Subtotal = $5,464,940 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	003	10	6/13/2024	NON-COMPETING CONTINUATION	$5,464,940
2024	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	9	3/19/2024	COMPETING CONTINUATION	$364,529
2024	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	7	3/19/2024	SUPPLEMENT FOR EXPANSION	-$113,119
2024	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	8	3/19/2024	NON-COMPETING CONTINUATION	-$251,410
														Subtotal = $5,464,940

Issue Date FY: 2023 ( Subtotal = $4,792,073 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	9	5/17/2023	COMPETING CONTINUATION	$4,792,073
														Subtotal = $4,792,073

Issue Date FY: 2021 ( Subtotal = $2,247,815 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	003	8	8/24/2021	NON-COMPETING CONTINUATION	$0
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	8	8/9/2021	NON-COMPETING CONTINUATION	$1,550,282
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	7	5/10/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	7	2/24/2021	SUPPLEMENT FOR EXPANSION	$697,533
														Subtotal = $2,247,815

Issue Date FY: 2020 ( Subtotal = $1,593,852 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	7	6/10/2020	NON-COMPETING CONTINUATION	$1,593,852
														Subtotal = $1,593,852

Issue Date FY: 2019 ( Subtotal = $1,686,549 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	6	9/24/2019	NON-COMPETING CONTINUATION	$0
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	6	6/11/2019	NON-COMPETING CONTINUATION	$1,686,549
														Subtotal = $1,686,549

Issue Date FY: 2018 ( Subtotal = $1,634,077 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	008	5	6/22/2018	NON-COMPETING CONTINUATION	$1,634,077
2018	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	006	4	1/8/2018	COMPETING CONTINUATION	$40,138
2018	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	4	11/2/2017	COMPETING CONTINUATION	-$1,736,994
2018	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	4	11/7/2017	COMPETING CONTINUATION	$1,736,994
2018	2016	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	005	3	12/29/2017	SUPPLEMENT FOR EXPANSION	$40,136
2018	2016	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	003	3	11/11/2017	SUPPLEMENT FOR EXPANSION	$0
2018	2016	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	007	3	1/8/2018	SUPPLEMENT FOR EXPANSION	-$40,138
2018	2015	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	3	11/10/2017	SUPPLEMENT FOR EXPANSION	$0
2018	2015	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	004	3	12/29/2017	SUPPLEMENT FOR EXPANSION	-$40,136
														Subtotal = $1,634,077

Issue Date FY: 2017 ( Subtotal = $1,736,994 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	4	9/15/2017	COMPETING CONTINUATION	$1,736,994
2017	2015	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	3	9/14/2017	NON-COMPETING CONTINUATION	$0
2017	2015	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	3	7/10/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,736,994

Issue Date FY: 2016 ( Subtotal = $133,250 )
2016	2016	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	3	9/7/2016	SUPPLEMENT FOR EXPANSION	$133,250
														Subtotal = $133,250

Issue Date FY: 2015 ( Subtotal = $1,039,799 )
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	3	8/28/2015	SUPPLEMENT FOR EXPANSION	$160,594
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	3	6/25/2015	NON-COMPETING CONTINUATION	$879,205
														Subtotal = $1,039,799

Issue Date FY: 2014 ( Subtotal = $990,263 )
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	2	9/15/2014	SUPPLEMENT FOR EXPANSION	$80,750
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	2	8/21/2014	NON-COMPETING CONTINUATION	$909,513
														Subtotal = $990,263

Issue Date FY: 2013 ( Subtotal = $907,898 ) (Continued on the next page)
Grand Total All Awards = $34,329,542

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Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI)

Award Number: P01AG041710

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2013

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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