Wednesday, July 16, 2025 7/16/2025

Frontotemporal Dementia: Genes, Images, and Emotions

Award Number: P01AG019724
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2002
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Frontotemporal Dementia: Genes, Images, and Emotions - PROJECT SUMMARY—Frontotemporal Dementia (FTD): Genes, Images, and Emotions Frontotemporal dementia (FTD) research is entering a new era of therapeutic discovery, spurred in part by contributions from this program project grant (PPG), entitled “Frontotemporal Dementia: Genes, Images, and Emotions,” which has a 20-year history of productivity and collaboration. In renewal, this PPG has been designed to close important clinical-translational knowledge gaps that could, if unaddressed, impede progress toward new therapies. The PPG will include four projects and seven cores. Project 1 will dissect the cognitive and emotional processes disrupted in FTD using novel laboratory and neuroimaging approaches and will translate this knowledge into automated, scalable tools for pathology prediction and disease-monitoring. Project 2 will link transcriptomic and proteomic discovery platforms to TDP-43 loss-of-function biology, seeking to develop new plasma-based molecular diagnostic and disease monitoring biomarkers. Project 3 will use laboratory-based emotions research methods to evaluate FTD caregivers, a group at risk for poor health outcomes, with an eye toward enhanced caregiver wellbeing and patient clinical trial participation. Project 4 will seek to identify sources of heterogeneity in FTD clinical progression and treatment goals. Core A (Administration) will oversee all aspects of the PPG to assure success of the project. Core B (Clinical) will recruit and evaluate patients and caregivers, including those from groups historically underrepresented in research, and collect clinical, neuropsychological, and functional assessments. Core C (Data Management and Biostatistics) will ensure data quality and availability and provide biostatistical consultation to all projects. Core D (Neuropathology) will coordinate autopsies and render neuropathological diagnoses, serving as the diagnostic gold standard and providing tissue for basic science and biomarker discovery efforts. Core E (Imaging) will acquire and process MRI scans and obtain amyloid-PET to detect AD in selected diagnostically uncertain patients. Core F (Genetics) will identify known genetic FTD pathogenic and risk variants through whole-exome sequencing and provide gene expression profiling in support of Project 2. Core G (Biospecimens) will obtain and bank biofluid specimens, provide samples and proteomics data to Projects 2 and 4, and use established fluid biomarkers to detect neurodegeneration and AD pathophysiology. These tightly integrated projects and cores will support our overall aim of accelerating progress in the era of FTD therapeutic discovery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $5,506,891 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	23	6/20/2025	NON-COMPETING CONTINUATION	$449,541
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	23	4/28/2025	NON-COMPETING CONTINUATION	$5,057,350
														Subtotal = $5,506,891

Issue Date FY: 2024 ( Subtotal = $5,446,505 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	002	22	4/17/2024	NON-COMPETING CONTINUATION	$5,446,505
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	21	3/19/2024	COMPETING CONTINUATION	$41,281
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	20	3/19/2024	SUPPLEMENT FOR EXPANSION	-$41,281
														Subtotal = $5,446,505

Issue Date FY: 2023 ( Subtotal = $5,536,934 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	002	21	7/21/2023	COMPETING CONTINUATION	$0
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	21	7/19/2023	COMPETING CONTINUATION	$5,553,559
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	20	10/25/2022	SUPPLEMENT FOR EXPANSION	-$16,625
														Subtotal = $5,536,934

Issue Date FY: 2022 ( Subtotal = $1,808,623 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	20	8/29/2022	SUPPLEMENT FOR EXPANSION	$1,808,623
														Subtotal = $1,808,623

Issue Date FY: 2021 ( Subtotal = $2,395,872 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	20	7/16/2021	SUPPLEMENT FOR EXPANSION	$19,299
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	20	7/12/2021	NON-COMPETING CONTINUATION	$2,357,274
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	002	20	7/19/2021	SUPPLEMENT FOR EXPANSION	$19,299
														Subtotal = $2,395,872

Issue Date FY: 2020 ( Subtotal = $2,410,901 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	003	19	6/30/2020	SUPPLEMENT FOR EXPANSION	$19,299
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	002	19	6/29/2020	SUPPLEMENT FOR EXPANSION	$19,299
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	19	5/21/2020	NON-COMPETING CONTINUATION	$2,372,303
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	18	4/15/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,410,901

Issue Date FY: 2019 ( Subtotal = $2,392,453 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	002	18	8/19/2019	SUPPLEMENT FOR EXPANSION	$23,552
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	003	18	9/11/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	001	18	6/10/2019	NON-COMPETING CONTINUATION	$2,368,901
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	17	2/22/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,392,453

Issue Date FY: 2018 ( Subtotal = $2,373,110 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	17	5/14/2018	NON-COMPETING CONTINUATION	$2,373,110
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	16	4/26/2018	COMPETING CONTINUATION	$0
														Subtotal = $2,373,110

Issue Date FY: 2017 ( Subtotal = $2,395,580 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	002	16	6/26/2017	COMPETING CONTINUATION	$113,015
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	004	16	9/25/2017	COMPETING CONTINUATION	$41,281
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	16	5/31/2017	COMPETING CONTINUATION	$1,967,009
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	001	16	6/5/2017	COMPETING CONTINUATION	$315,556
2017	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	003	15	9/25/2017	EXTENSION WITH OR WITHOUT FUNDS	-$41,281
														Subtotal = $2,395,580

Issue Date FY: 2016 ( Subtotal = $1,901,680 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	15	5/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,901,680
														Subtotal = $1,901,680

Issue Date FY: 2015 ( Subtotal = $1,835,989 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	14	5/18/2015	NON-COMPETING CONTINUATION	$1,835,989
														Subtotal = $1,835,989

Issue Date FY: 2014 ( Subtotal = $1,891,742 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	13	5/31/2014	NON-COMPETING CONTINUATION	$1,891,742
														Subtotal = $1,891,742

Issue Date FY: 2013 ( Subtotal = $1,781,427 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	12	9/4/2013	NON-COMPETING CONTINUATION	$1,781,427
														Subtotal = $1,781,427

Issue Date FY: 2012 ( Subtotal = $1,959,873 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	11	8/16/2012	COMPETING CONTINUATION	$1,959,873
														Subtotal = $1,959,873

Issue Date FY: 2011 ( Subtotal = $1,682,474 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	10	8/10/2011	NON-COMPETING CONTINUATION	$1,682,474
														Subtotal = $1,682,474

Issue Date FY: 2010 ( Subtotal = $1,708,405 )
2010	2010	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	9	8/11/2010	NON-COMPETING CONTINUATION	$1,708,405
														Subtotal = $1,708,405

Grand Total All Awards = $55,822,861

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Frontotemporal Dementia: Genes, Images, and Emotions

Award Number: P01AG019724

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2002

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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