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DNA Repair, Mutations and Cellular Aging

Award Number: P01AG017242
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1999
PERIOD OF PERFORMANCE END DATE: 04/30/2024

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DNA Repair, Mutations and Cellular Aging - ABSTRACT – Overall Progress in aging research over the last two decades has now firmly established an important role for DNA damage and genome instability in age-related cellular degeneration and death. Since its inception in 1999 investigators in this PPG demonstrated that genetic defects in some but not all DNA repair pathways are associated with premature aging phenotypes in mice, developed the first methods to detect spontaneous DNA mutations in primary tissues, identified transcription stress as a novel age-related molecular phenotype, developed a mouse model to detect and eliminate senescent cells in mice and subsequently demonstrated causality in aging phenotypes, and provided the first evidence that rare genetic variants in genome maintenance pathways are enriched in human centenarians. Studies from other groups have confirmed many of our conclusions, and genome instability is now regarded a hallmark of aging. However, what remains lacking is specific insight into the genetic control and molecular mechanisms that link DNA damage and genome instability to aging and longevity in humans. This renewal application is organized around three major research questions that remain in this field: (1) the key genome maintenance genotypes that control human aging and longevity; (2) the genetic and molecular basis of DNA damage-driven aging; and (3) How DNA damage and its molecular sequelae affect cell fate diversity in aging. These key questions will be addressed jointly and in an integrated manner by four research projects, an Administrative Core and a Bioinformatics Core. We expect that the resulting specific insight into the role of DNA damage and repair in human aging will give us the means to develop interventions to minimize the adverse effects of DNA damage metabolism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,980,580 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	28	5/8/2023	NON-COMPETING CONTINUATION	$1,980,580
														Subtotal = $1,980,580

Issue Date FY: 2022 ( Subtotal = $1,993,062 )
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	004	27	7/12/2022	NON-COMPETING CONTINUATION	$1,993,062
2022	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	24	10/12/2021	COMPETING CONTINUATION	$1,422,755
2022	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	002	24	10/12/2021	COMPETING CONTINUATION	$1,052
2022	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	23	10/12/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,422,755
2022	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	003	23	10/12/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,052
														Subtotal = $1,993,062

Issue Date FY: 2021 ( Subtotal = $1,999,051 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	002	26	6/16/2021	NON-COMPETING CONTINUATION	$1,999,051
2021	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	24	5/21/2021	COMPETING CONTINUATION	-$1,422,755
2021	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	23	5/21/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,422,755
														Subtotal = $1,999,051

Issue Date FY: 2020 ( Subtotal = $2,722,291 )
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	003	25	7/30/2020	SUPPLEMENT FOR EXPANSION	$419,479
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	004	25	7/31/2020	SUPPLEMENT FOR EXPANSION	$286,947
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	002	25	4/30/2020	NON-COMPETING CONTINUATION	$2,015,865
2020	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	24	3/14/2020	COMPETING CONTINUATION	$1,423,807
2020	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	23	3/14/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,423,807
														Subtotal = $2,722,291

Issue Date FY: 2019 ( Subtotal = $2,253,789 )
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	009	24	8/14/2019	COMPETING CONTINUATION	$154,903
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	004	24	6/25/2019	COMPETING CONTINUATION	$2,098,886
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	003	23	6/24/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	22	2/8/2019	NON-COMPETING CONTINUATION	-$1,138,702
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	008	22	7/24/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	007	23	7/16/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,392,014
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	005	22	7/16/2019	SUPPLEMENT FOR EXPANSION	-$526,204
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	22	1/15/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	006	22	7/16/2019	NON-COMPETING CONTINUATION	-$865,810
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	002	23	2/8/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,138,702
														Subtotal = $2,253,789

Issue Date FY: 2018 ( Subtotal = $3,211,307 )
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	22	8/23/2018	NON-COMPETING CONTINUATION	$0
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	22	7/30/2018	NON-COMPETING CONTINUATION	$2,685,103
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	002	22	9/13/2018	SUPPLEMENT FOR EXPANSION	$526,204
														Subtotal = $3,211,307

Issue Date FY: 2017 ( Subtotal = $2,740,123 )
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	001	21	6/21/2017	NON-COMPETING CONTINUATION	$274,013
2017	2017	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Aging Research	000	21	5/12/2017	NON-COMPETING CONTINUATION	$2,466,110
														Subtotal = $2,740,123

Issue Date FY: 2016 ( Subtotal = $2,744,971 )
2016	2016	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Aging Research	000	20	6/14/2016	NON-COMPETING CONTINUATION	$2,744,971
														Subtotal = $2,744,971

Issue Date FY: 2015 ( Subtotal = $2,646,873 )
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	18	4/3/2015	NON-COMPETING CONTINUATION	$2,646,873
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE INC	111 E 210TH ST	BRONX	NY	10467	BRONX	USA	Aging Research	002	19	9/22/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,764,582
2015	2015	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	18	9/21/2015	NON-COMPETING CONTINUATION	-$1,764,582
														Subtotal = $2,646,873

Issue Date FY: 2014 ( Subtotal = $2,839,070 )
2014	2014	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	17	9/16/2014	COMPETING CONTINUATION	$2,839,070
2014	2013	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	16	9/12/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,839,070

Issue Date FY: 2013 ( Subtotal = $1,956,982 )
2013	2013	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	16	5/6/2013	NON-COMPETING CONTINUATION	$1,863,794
2013	2013	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	001	16	5/15/2013	NON-COMPETING CONTINUATION	$93,188
														Subtotal = $1,956,982

Issue Date FY: 2012 ( Subtotal = $2,086,375 )
2012	2012	ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIV	1300 MORRIS PARK AVENUE	BRONIX	NY	10461		USA	Aging Research	000	15	3/2/2012	NON-COMPETING CONTINUATION	$2,086,375
														Subtotal = $2,086,375

Grand Total All Awards = $46,837,301

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DNA Repair, Mutations and Cellular Aging

Award Number: P01AG017242

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1999

PERIOD OF PERFORMANCE END DATE: 04/30/2024

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