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Neurobiology of Mild Cognitive Impairment in the Elderly

Award Number: P01AG014449
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/1997
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Neurobiology of Mild Cognitive Impairment in the Elderly - OVERALL PROGRAM SUMMARY/ABSTRACT Alzheimer’s disease (AD) is a devastating progressive neurodegenerative disorder affecting >6 million older people in the USA for which there is no viable treatment option. Accordingly, defining the earliest cellular and molecular mechanisms that drive the preclinical phase of dementia to develop novel disease modifying therapeutics is a public health priority worldwide. The thrust of our PPG entitled “Neurobiology of Mild Cognitive Impairment in the Elderly” continues to be to elucidate the cellular and molecular basis or chain of events leading from no cognitive impairment (NCI) to mild cognitive impairment (MCI), the time-points considered the most likely therapeutic windows for treating dementia. Moreover, we continue to focus our efforts on NCI subjects with AD pathology suggestive of preclinical AD, in order to resolve the molecular and cellular neuropathogenic sequela underlying this preclincal stage of the disease. We will implement a series of interrelated connectome projects centered on the cholinergic basal forebrain (CBF)-default mode network (DMN) circuit, which is critical for memory and executive function and displays early pathology and biomaker activity prior to MCI (prodromal AD). CBF neuron dysfunction plays a pivotal role in the onset of clinical dementia and is the basis for the majority of FDA approved drugs for AD. This PPG competitive renewal application continues to bring together a number of basic and clinical scientists with multidisciplinary, complementary expertise in preclinical AD to investigate circuit-based neuronal system dysfunction at the earliest stages in the disease process. The PPG includes an Administrative & Clinical/Tissue Distribution Core, a Statistics & Data Management Core and three research projects titled: Tau Abnormalities and Mild Cognitive Impairment in the Elderly Scott Counts, Project Leader, PL, Michigan State University, Cholinergic Basal Forebrain Neurotrophic Abnormalities and Mild Cognitive Impairment in the Elderly (Elliott Mufson, PL, Barrow Neurologic Institute/Banner Alzheimer’s Institute), and Synaptic and Cholinergic Abnormalities in Mild Cognitive Impairment in the Elderly (Milos Ikonomovic, PL University of Pittsburgh). The Cores support each Project and all Projects interact intellectually, scientifically, and thematically. All Cores and Projects utilize the same Rush Religious Orders Study (RROS) cases and tissues for continuity, which confers the ability to correlate biologic measures with cognitive and neuropathological criterion. The lack of true animal models and a lack of efficacy of current drugs make our human clinical pathological studies particularly relevant for understanding mechanisms of preclinical AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	DIGNITY HEALTH	350 W THOMAS RD	PHOENIX	AZ	85013	MARICOPA	USA	Aging Research	000	26	10/17/2024	NON-COMPETING CONTINUATION	$0
2025	2024	DIGNITY HEALTH	350 W THOMAS RD	PHOENIX	AZ	85013	MARICOPA	USA	Aging Research	001	26	2/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,396,025 )
2024	2024	DIGNITY HEALTH	185 BERRY ST STE 200	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	26	6/17/2024	NON-COMPETING CONTINUATION	$2,396,025
														Subtotal = $2,396,025

Issue Date FY: 2023 ( Subtotal = $2,396,025 )
2023	2023	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	25	5/17/2023	NON-COMPETING CONTINUATION	$2,396,025
2023	2020	DIGNITY HEALTH	185 BERRY ST STE 200	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	22	4/11/2023	COMPETING CONTINUATION	-$727,482
2023	2019	DIGNITY HEALTH	185 BERRY ST STE 200	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	21	4/11/2023	NON-COMPETING CONTINUATION	$727,482
														Subtotal = $2,396,025

Issue Date FY: 2022 ( Subtotal = $2,394,525 )
2022	2022	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	24	4/5/2022	NON-COMPETING CONTINUATION	$2,394,525
														Subtotal = $2,394,525

Issue Date FY: 2021 ( Subtotal = $2,252,409 )
2021	2021	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	003	23	6/11/2021	NON-COMPETING CONTINUATION	$2,390,023
2021	2020	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	22	5/13/2021	COMPETING CONTINUATION	-$137,614
2021	2020	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	22	4/29/2021	COMPETING CONTINUATION	$1,150,364
2021	2019	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	21	4/29/2021	NON-COMPETING CONTINUATION	-$1,150,364
														Subtotal = $2,252,409

Issue Date FY: 2020 ( Subtotal = $2,659,479 )
2020	2020	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	22	4/9/2020	COMPETING CONTINUATION	$0
2020	2020	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	22	3/25/2020	COMPETING CONTINUATION	$2,659,479
2020	2019	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	21	3/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,659,479

Issue Date FY: 2019 ( Subtotal = $1,681,922 )
2019	2019	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	21	3/14/2019	NON-COMPETING CONTINUATION	$1,681,922
														Subtotal = $1,681,922

Issue Date FY: 2018 ( Subtotal = $1,682,041 )
2018	2018	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	20	1/30/2018	NON-COMPETING CONTINUATION	$1,513,837
2018	2018	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	002	20	6/22/2018	NON-COMPETING CONTINUATION	$0
2018	2018	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	001	20	4/19/2018	NON-COMPETING CONTINUATION	$168,204
														Subtotal = $1,682,041

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	DIGNITY HEALTH	185 BERRY ST STE 300	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Aging Research	000	19	2/17/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $1,962,706 )
2016	2016	ST JOSEPH'S HOSPITAL, BARROW NEUROLOGICAL INSTITUTE	POST OFFICE BOX 2071	PHOENIX	AZ	85001	MARICOPA	USA	Aging Research	000	19	4/13/2016	NON-COMPETING CONTINUATION	$1,962,706
														Subtotal = $1,962,706

Issue Date FY: 2015 ( Subtotal = $1,901,499 )
2015	2015	ST JOSEPH'S HOSPITAL, BARROW NEUROLOGICAL INSTITUTE	POST OFFICE BOX 2071	PHOENIX	AZ	85001	MARICOPA	USA	Aging Research	002	18	3/30/2015	NON-COMPETING CONTINUATION	$1,901,499
2015	2014	ST JOSEPH'S HOSPITAL, BARROW NEUROLOGICAL INSTITUTE	POST OFFICE BOX 2071	PHOENIX	AZ	85001	MARICOPA	USA	Aging Research	001	17	11/28/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,090,150
2015	2014	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	16	11/26/2014	COMPETING CONTINUATION	-$1,090,150
														Subtotal = $1,901,499

Issue Date FY: 2014 ( Subtotal = $1,858,470 )
2014	2014	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	001	16	1/29/2014	COMPETING CONTINUATION	$2,248,976
2014	2014	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	002	16	2/20/2014	COMPETING CONTINUATION	-$390,506
2014	2012	RUSH UNIVERSITY MEDICAL CENTER	1653 WEST CONGRESS WAY	CHICAGO	IL	60612	COOK	USA	Aging Research	000	15	1/24/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,858,470

Issue Date FY: 2012 ( Subtotal = $1,827,491 )
2012	2012	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	15	3/19/2012	NON-COMPETING CONTINUATION	$1,827,491
														Subtotal = $1,827,491

Issue Date FY: 2011 ( Subtotal = $1,346,902 )
2011	2011	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	14	3/24/2011	NON-COMPETING CONTINUATION	$1,261,191
2011	2011	RUSH-PRESBYTERIAN-ST LUKE`S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	001	14	6/29/2011	NON-COMPETING CONTINUATION	$85,711
														Subtotal = $1,346,902

Issue Date FY: 2010 ( Subtotal = $2,345,950 )
2010	2010	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	001	13	9/30/2010	NON-COMPETING CONTINUATION	$500,000
2010	2010	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	13	3/19/2010	NON-COMPETING CONTINUATION	$1,845,950
														Subtotal = $2,345,950

Issue Date FY: 2009 ( Subtotal = $1,816,351 )
2009	2009	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	12	4/13/2009	NON-COMPETING CONTINUATION	$1,816,351
														Subtotal = $1,816,351

Issue Date FY: 2008 ( Subtotal = $1,834,847 )
2008	2008	RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER	1700 WEST VAN BUREN STREET	CHICAGO	IL	60612	COOK	USA	Aging Research	000	11	3/31/2008	COMPETING CONTINUATION	$1,834,847
														Subtotal = $1,834,847

Grand Total All Awards = $41,400,721

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Neurobiology of Mild Cognitive Impairment in the Elderly

Award Number: P01AG014449

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/1997

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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