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Mitochondrial Protective Interventions, Aging and Healthspan

Award Number: P01AG001751
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/1997
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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Mitochondrial Protective Interventions, Aging and Healthspan - OVERALL: MITOCHONDRIAL PROTECTIVE INTERVENTIONS, AGING AND HEALTHSPAN P01 - SUMMARY/ABSTRACT We propose a highly focused, integrated and interactive effort to examine the hypothesis that mitochondrial targeted therapeutics are capable of resisting age-related disease and improving health and function in multiple organ systems in aging mammals. We are focused on heart, skeletal muscle and retina (vision) in aging; the vital function of each of these organs is highly reliant on mitochondrial energetics; each declines reproducibly with age and each contributes to frailty in the elderly human population. Most importantly, we show evidence that each of these age related healthspan limitations can be not just attenuated, but substantially reversed in old animals treated with a mitochondrial therapeutic agent, the tetrapeptide drug SS- 31. Thus, we have developed a strong translational goal of applying mitochondrial protective agents to achieve substantial health benefits in the aging mammalian models of mice and rats. The potential translational impact of this approach is high, as SS-31 is already in multiple phase II clinical trials, including three inspired by the prior animal studies performed by our P01 investigators. We propose three Projects: 1) Mitochondrial ROS and Cardiac Aging (Rabinovitch); 2) Mitochondrial Function and Skeletal Muscle Aging (Marcinek) and 3) Mitochondrial Function and Vision Aging (Prusky/Szeto). While each of these thee projects has their specific organ focus, each also shares a common third Aim of working jointly to establish the healthspan and lifespan benefits of SS-31 when it is continuously delivered to mice beginning at middle age, with and without the added stress of a high fat diet. We propose 5 Cores to provide vital support and services that are used by all three projects to accomplish their aims: A: Administration (Rabinovitch); B: Murine Healthspan and Lifespan, (Ladiges); C: Proteomics (MacCoss); D: Mitochondrial Protective Chemistry (Szeto) and E: Magnetic Resonance & Optics Spectroscopy (Conley).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$8,968 )
2024	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	37	12/7/2023	NON-COMPETING CONTINUATION	-$8,968
														Subtotal = -$8,968

Issue Date FY: 2021 ( Subtotal = $1,996,314 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	37	4/2/2021	NON-COMPETING CONTINUATION	$1,996,314
														Subtotal = $1,996,314

Issue Date FY: 2020 ( Subtotal = $1,996,314 )
2020	2020	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	36	3/27/2020	NON-COMPETING CONTINUATION	$1,996,314
														Subtotal = $1,996,314

Issue Date FY: 2019 ( Subtotal = $1,996,314 )
2019	2019	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	35	4/18/2019	NON-COMPETING CONTINUATION	$1,996,314
														Subtotal = $1,996,314

Issue Date FY: 2018 ( Subtotal = $2,153,375 )
2018	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	34	5/18/2018	NON-COMPETING CONTINUATION	$2,153,375
														Subtotal = $2,153,375

Issue Date FY: 2017 ( Subtotal = $2,337,196 )
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	004	33	8/29/2017	SUPPLEMENT FOR EXPANSION	$154,563
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	003	33	7/27/2017	SUPPLEMENT FOR EXPANSION	$159,067
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	002	33	5/16/2017	COMPETING CONTINUATION	$60,326
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	33	3/24/2017	COMPETING CONTINUATION	$2,023,566
2017	2015	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Aging Research	001	32	5/16/2017	NON-COMPETING CONTINUATION	-$60,326
														Subtotal = $2,337,196

Issue Date FY: 2015 ( Subtotal = $1,834,106 )
2015	2015	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	32	3/6/2015	NON-COMPETING CONTINUATION	$1,834,106
														Subtotal = $1,834,106

Issue Date FY: 2014 ( Subtotal = $1,866,109 )
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	31	3/4/2014	NON-COMPETING CONTINUATION	$1,866,109
														Subtotal = $1,866,109

Issue Date FY: 2013 ( Subtotal = $1,765,370 )
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	30	3/29/2013	NON-COMPETING CONTINUATION	$1,681,304
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	001	30	5/23/2013	NON-COMPETING CONTINUATION	$84,066
														Subtotal = $1,765,370

Issue Date FY: 2012 ( Subtotal = $1,868,417 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	29	2/20/2012	NON-COMPETING CONTINUATION	$1,868,417
														Subtotal = $1,868,417

Issue Date FY: 2011 ( Subtotal = $1,894,689 )
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	28	3/11/2011	COMPETING CONTINUATION	$1,894,689
														Subtotal = $1,894,689

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	27	7/15/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $1,819,964 )
2007	2007	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	27	8/23/2007	NON-COMPETING CONTINUATION	$1,819,964
														Subtotal = $1,819,964

Issue Date FY: 2006 ( Subtotal = $1,843,916 )
2006	2006	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	26	8/16/2006	NON-COMPETING CONTINUATION	$1,843,916
														Subtotal = $1,843,916

Issue Date FY: 2005 ( Subtotal = $1,867,959 )
2005	2005	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	25	8/24/2005	NON-COMPETING CONTINUATION	$1,867,959
														Subtotal = $1,867,959

Issue Date FY: 2004 ( Subtotal = $1,707,015 )
2004	2004	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	24	8/25/2004	NON-COMPETING CONTINUATION	$1,707,015
														Subtotal = $1,707,015

Issue Date FY: 2003 ( Subtotal = $1,620,625 )
2003	2003	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98195	KING	USA	Aging Research	000	23	9/29/2003	COMPETING CONTINUATION	$1,620,625
														Subtotal = $1,620,625

Issue Date FY: 2000 ( Subtotal = $999,409 )
2000	2000	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	22	8/22/2000	NON-COMPETING CONTINUATION	$999,409
														Subtotal = $999,409

Issue Date FY: 1999 ( Subtotal = $965,676 )
1999	1999	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	21	8/5/1999	NON-COMPETING CONTINUATION	$965,676
														Subtotal = $965,676

Issue Date FY: 1998 ( Subtotal = $953,199 )
1998	1998	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Aging Research	000	20	7/21/1998	NON-COMPETING CONTINUATION	$953,199
														Subtotal = $953,199

Grand Total All Awards = $31,476,999

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Mitochondrial Protective Interventions, Aging and Healthspan

Award Number: P01AG001751

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/1997

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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