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Addressing alcohol misuse in HIV prevention and care: The Brown University Alcohol Research Center on HIV (ARCH)

Award Number: P01AA019072
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Overall Project Summary Alcohol misuse impacts the depth and breadth of the HIV epidemic, both domestically and globally, through multiple pathways—increasing sexual risk behaviors, reducing adherence to antiretroviral therapy, and increasing the risk for HIV-associated comorbidities and mortality. To reduce the incidence of HIV, approaches must be developed that concurrently address alcohol misuse in the context of HIV testing and behavioral and biomedical prevention approaches. Likewise, to increase rates of HIV viral suppression and reduce HIV-related comorbidities, alcohol misuse must be addressed effectively in diverse populations across a spectrum of HIV care settings. The Brown University Alcohol Research Center on HIV (ARCH) has been supporting collaborative research to develop scalable alcohol-HIV interventions, including video counseling, telehealth, and web-enabled applications, that can be delivered broadly and efficiently using centralized personnel and technological resources. This application to renew the Brown ARCH is organized around the central theme that in order to achieve population impact, interventions addressing alcohol misuse in HIV prevention and care need to be evaluated with an emphasis on real-world effectiveness, scalability, and sustainability, according to the principles of implementation science. Specifically, we propose three projects that leverage our unique strengths in (a) training professionals in alcohol misuse interventions, (b) utilizing video counseling and telehealth as scalable means of reaching populations and providing continuing care, and (c) utilizing behavioral intervention technologies to provide alcohol interventions and ongoing support for change. Research Component 1 (MPI: Wray and Monti) extends our work on the role of alcohol use in HIV transmission among men who have sex with men (MSM) by testing the effectiveness of a web-based intervention that addresses both alcohol use and sex risk in MSM completing HIV self-testing. Research Component 2 (PI: Kahler) extends our work on behavioral telehealth interventions to reduce alcohol misuse in HIV-infected MSM by testing our previously developed video counseling and text messaging interventions in a diverse sample of patients in HIV care at four large, urban federally-qualified health centers. Research Components 1 and 2 share a Hybrid Type 1 effectiveness-implementation trial design, providing data on real-world effectiveness while gathering data related to implementation to inform future studies. Research Component 3 (MPI: Becker and Kuo) complements these projects by conducting an implementation trial that evaluates a cascading training model to promote alcohol screening and brief intervention across HIV care settings in South Africa. Together, these projects—supported by an Administrative Core, Research Methods Core, and Program Advisory Committee and complemented by an outstanding training program in alcohol-HIV research with robust pilot funding opportunities—will make a substantial impact in translating basic and applied knowledge on alcohol and HIV into scalable approaches to reducing the negative impact of alcohol misuse on HIV prevention and care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,191,410 )
2023	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	14	6/30/2023	NON-COMPETING CONTINUATION	$1,191,410
2023	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	13	1/24/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,191,410

Issue Date FY: 2022 ( Subtotal = $1,344,024 )
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	13	6/18/2022	NON-COMPETING CONTINUATION	$1,203,071
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	002	13	6/21/2022	SUPPLEMENT FOR EXPANSION	$140,953
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	12	12/16/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,344,024

Issue Date FY: 2021 ( Subtotal = $1,398,472 )
2021	2021	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	004	12	5/27/2021	NON-COMPETING CONTINUATION	$1,241,580
2021	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	005	12	9/15/2021	SUPPLEMENT FOR EXPANSION	$156,892
2021	2020	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	002	11	11/13/2020	COMPETING CONTINUATION	$1,575,294
2021	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	003	11	4/16/2021	COMPETING CONTINUATION	$0
2021	2019	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	10	11/13/2020	NON-COMPETING CONTINUATION	-$1,234,319
2021	2018	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	9	11/13/2020	NON-COMPETING CONTINUATION	-$340,975
														Subtotal = $1,398,472

Issue Date FY: 2020 ( Subtotal = $1,353,170 )
2020	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	11	7/1/2020	COMPETING CONTINUATION	$1,353,170
2020	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	10	6/23/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,353,170

Issue Date FY: 2019 ( Subtotal = $1,234,319 )
2019	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	10	7/16/2019	NON-COMPETING CONTINUATION	$1,234,319
														Subtotal = $1,234,319

Issue Date FY: 2018 ( Subtotal = $1,231,561 )
2018	2018	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	9	5/17/2018	NON-COMPETING CONTINUATION	$1,231,561
														Subtotal = $1,231,561

Issue Date FY: 2017 ( Subtotal = $1,244,238 )
2017	2017	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	8	5/31/2017	NON-COMPETING CONTINUATION	$1,244,238
														Subtotal = $1,244,238

Issue Date FY: 2016 ( Subtotal = $1,369,966 )
2016	2016	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	7	6/22/2016	NON-COMPETING CONTINUATION	$1,270,011
2016	2016	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	7	9/8/2016	SUPPLEMENT FOR EXPANSION	$99,955
														Subtotal = $1,369,966

Issue Date FY: 2015 ( Subtotal = $1,287,649 )
2015	2015	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	001	6	8/27/2015	COMPETING CONTINUATION	$1,216,698
2015	2015	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	002	6	9/25/2015	COMPETING CONTINUATION	$70,951
2015	2014	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	5	8/27/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,287,649

Issue Date FY: 2014 ( Subtotal = $1,232,310 )
2014	2014	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	5	8/6/2014	NON-COMPETING CONTINUATION	$1,232,310
														Subtotal = $1,232,310

Issue Date FY: 2013 ( Subtotal = $1,243,905 )
2013	2013	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	4	8/31/2013	NON-COMPETING CONTINUATION	$1,243,905
														Subtotal = $1,243,905

Issue Date FY: 2012 ( Subtotal = $1,438,104 )
2012	2012	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	3	8/15/2012	NON-COMPETING CONTINUATION	$1,438,104
														Subtotal = $1,438,104

Issue Date FY: 2011 ( Subtotal = $1,392,208 )
2011	2011	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	2	8/15/2011	NON-COMPETING CONTINUATION	$1,392,208
														Subtotal = $1,392,208

Issue Date FY: 2010 ( Subtotal = $1,484,315 )
2010	2010	BROWN UNIVERSITY	POST OFFICE BOX 1929	PROVIDENCE	RI	02912	PROVIDENCE	USA	Alcohol Research Programs	000	1	9/30/2010	NEW	$1,484,315
														Subtotal = $1,484,315

Grand Total All Awards = $18,445,651

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Addressing alcohol misuse in HIV prevention and care: The Brown University Alcohol Research Center on HIV (ARCH)

Award Number: P01AA019072

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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