Primary Care - Building Research Integration in Diverse Geographic Environments (PC-BRIDGE) - ABSTRACT Primary care, particularly family medicine, is essential in New Mexico (NM), a state with serious challenges alongside unique cultural resiliencies. NM has the highest degree of social vulnerability in the U.S. Its diverse, underserved population has significant numbers of people who are Hispanic or Latino (50%) and/or Native American (11%). A quarter (25.5%) of its population lives in formally designated rural/frontier counties. Additionally, 32/33 NM Counties are designated as Health Professions Shortage Areas, resulting in significant competing demands for its clinical workforce. The proposed network research hub, Primary Care – Building Research Integration in Diverse Geographic Environments (PC- BRIDGE), will leverage the substantial primary care practice- and community-engaged research infrastructure at the University of New Mexico to extend research participation opportunities to NM communities often underrepresented in clinical research through the following specific aims: 1) Engage rural primary care settings serving underrepresented populations to enhance and expand research capacity; 2) Equitably engage diverse NM communities through people- and patient-centric trust-building strategies and clinical research adaptations that identify, employ, and disseminate best practices in inclusive participatory research; 3) Inform research and clinical alignment through discovery and/or adoption of innovative yet feasible strategies that cause minimal disruption to clinical workflows while achieving progress toward a learning health systems framework that accelerates the adoption of evidence into clinical practice; and 4) Participate actively in a national community of practice through work group participation, quality assurance processes, collaborative relationship building with network hub partners and evaluation and dissemination of best practices in primary care research.