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Northwest Genomics Center for All of Us

Award Number: OT2OD038111
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Northwest Genomics Center for All of Us - The goals of the Northwest Genomics Center (NWGC) for All of Us (AoU) are to provide high-quality, cost-effective genotyping and whole genome sequence (WGS) data; to return genomic results for medically actionable and pharmacogenomic genetic variants; to enhance the scientific value of AoU by adding innovative -omic technologies including long-read sequence data. The NWGC brings together three internationally recognized Principal Investigators–Gail Jarvik, Chia-Lin Wei, and Evan Eichler–with decades of expertise in high-throughput clinical genomics. Together with their Co-Investigators—Christina Lockwood, Colin Pritchard, and Phil Empey—they have returned tens of thousands of variant interpretations to patients including AoU participants. Since August 2020, the NWGC has delivered genotype array data for 169,414 samples and genome data for 61,606 samples to the AoU Data Research Center (DRC). We have completed variant review and classification resulting in genomic return of results reports for more than 15,000 AoU participants including 411 medically actionable reports (i.e., American College of Medical Genetics pathogenic or likely pathogenic classifications). To advance the core business goals and objectives of AoU, the NWGC will generate high-quality genotyping array and whole genome sequence data for up to 50,000 AoU participants per year. In addition, we will interpret and classify variants for individuals who request genomic return of results (gRoR). We will continue to lead and support expanding gRoR content to participants (i.e., additional genes and medications) and leverage long-read -omics projects for investigators in the Researcher Work Bench (RWB). We will contribute our in-depth experience in sequencing technologies to support the FDA IDE supplemental validation plans for the NovaSeq X Plus platform and construct long-read resources in the discovery of pathogenic variants in medically- relevant genes and PGx targets. We will participate in analysis working groups and work with the DRC to improve genotype imputation and phasing tools, when funding is available, we will deploy innovative multiomics technologies to expand variant interpretation and functional annotation. The NWGC is ideally positioned to support and maximize the potential of AoU and its central mission to understand human genetic variation that impacts disease prevalence in the United States population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Trans-NIH Research Support	000	1	4/9/2026	SUPPLEMENT FOR EXPANSION	$0
2026	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	21st Century Cures Act - Precision Medicine Initiative	001	1	7/14/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $699,807 )
2025	2025	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Trans-NIH Research Support	000	1	7/29/2025	SUPPLEMENT FOR EXPANSION	$699,807
														Subtotal = $699,807

Issue Date FY: 2024 ( Subtotal = $2,999,628 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	21st Century Cures Act - Precision Medicine Initiative	000	1	8/1/2024	NEW	$2,999,628
														Subtotal = $2,999,628

Grand Total All Awards = $3,699,435

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Northwest Genomics Center for All of Us

Award Number: OT2OD038111

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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