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EMAI-COPD: An Ethical Multimodal AI Model for Preventive, Diagnostic, and Therapeutic Interventions in Chronic Obstructive Pulmonary Disease

Award Number: OT2OD038074
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 09/08/2025
PERIOD OF PERFORMANCE END DATE: 09/07/2027

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EMAI-COPD: An Ethical Multimodal AI Model for Preventive, Diagnostic, and Therapeutic Interventions in Chronic Obstructive Pulmonary Disease - Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality in the United States. We propose to integrate existing omics data (genetic, transcriptomic, epigenetic, proteomic, metabolomics, and spirometrics) from multiple TOPMed cohorts, medical imaging data (CT), wearable data (Fitbit and Apple), social determinants of health (SDOH), and clinical research data (text and tabular) to develop EMAI-COPD, a novel and open-source ethics-aware multimodal AI (MAI) model to enable a variety of downstream applications in preventive, diagnostic and therapeutic interventions in COPD. These include medical applications, such as disease progression and prediction modeling, disease subtyping and pathway analysis, and early exacerbation detection. We envision EMAI-COPD as both a blueprint and a starting model to be adopted and adapted to generate a family EMAI-X models for other diseases (i.e., “X”). Our team is well positioned to take on this task. The team constitutes of 1) AI experts with extensive research experience in introducing novel AI models as well as agile model development lifecycle for large- scale models, 2) domain experts with decades of research and clinical experience in COPD interventions, and 3) medical ethics experts that could help us form the ethics framework required to develop EMAI- COPD as an intrinsically ethics-aware tool, including awareness of bias, fairness, privacy, accountability and transparency. Along with a wide set of stakeholders, which have worked with the team in the past, this team will adopt an agile approach to co-design and enhance EMAI-COPD to meet all ethical and performance requirements of the model.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,267,926 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	001	1	8/14/2026	SUPPLEMENT FOR EXPANSION	$1,267,926
2026	2025	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	1	8/14/2026	NEW	$0
														Subtotal = $1,267,926

Issue Date FY: 2025 ( Subtotal = $1,592,119 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Trans-NIH Research Support	000	1	9/3/2025	NEW	$1,592,119
														Subtotal = $1,592,119

Grand Total All Awards = $2,860,045

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EMAI-COPD: An Ethical Multimodal AI Model for Preventive, Diagnostic, and Therapeutic Interventions in Chronic Obstructive Pulmonary Disease

Award Number: OT2OD038074

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 09/08/2025

PERIOD OF PERFORMANCE END DATE: 09/07/2027

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