Thursday, September 18, 2025 9/18/2025

Comprehensive reference atlas construction, geolocation and data integration for HuBMAP HIVE [5 of 5]

Award Number: OT2OD033760
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Comprehensive reference atlas construction, geolocation and data integration for HuBMAP HIVE [5 of 5] - Abstract The Human BioMolecular Atlas Program (HuBMAP) is redefining our understanding of the human body by recovering multi-scale tissue organization--anatomical, histological, and molecular--at unprecedented resolution, through computational integration of diverse experimental measurements. The current HuBMAP HIVE has led the development of a human common coordinate framework (CCF); constructed molecularly and spatially resolved reference maps of human tissues; developed mapping frameworks for the interpretation of new datasets; and coordinated extensive collaborative activities both within HuBMAP and with the broader community. In Y5-8, we will construct a Human Reference Atlas (HRA), establishing the HuBMAP Portal as the “go-to” resource for human tissue reference maps and multimodal single-cell data. We propose a Mapping Center to build upon our progress in Y1-4, and achieve these goals. Our center represents a synergistic collaboration between three labs, Dr. Rahul Satija (NYGC/NYU), Dr. John Marioni (EMBL/EBI), and Dr. Jean Fan (JHU). Our Mapping Center proposes to lead a series of key tasks for HuBMAP. These include the construction of single-cell reference maps for 30 human tissues, where maps will be constructed by harmonizing a wide diversity of multimodal single-cell technologies. We also propose to lead the development of mapping tools that will enable users in the community to upload their own datasets and map them to HuBMAP references. Importantly, these tools will not be limited to single-cell RNA sequencing datasets, but will be extended to process datasets that measure chromatin accessibility, chromatin modifications, DNA methylation, intracellular and surface protein levels, and metabolic profiles as well. We also propose to lead the development of statistical methods to perform comparative analysis of multiple datasets. This will enable key use-cases for users both within and outside of HuBMAP, including the ability to perform comparative analysis of healthy vs. diseased tissue. We expect our MC to work together with and lead the HubMAP community to a deeper understanding of the functional organization of human tissues and, and to explore how molecular state, environment, and anatomical location, affect cellular identity and behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,648,288 )
2025	2025	NEW YORK GENOME CENTER, INC.	101 AVENUE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	001	1	8/27/2025	SUPPLEMENT FOR EXPANSION	$1,648,288
2025	2022	NEW YORK GENOME CENTER, INC.	101 AVENUE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	000	1	8/22/2025	NEW	$0
														Subtotal = $1,648,288

Issue Date FY: 2024 ( Subtotal = $1,500,000 )
2024	2024	NEW YORK GENOME CENTER, INC.	101 AVENUE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	001	1	8/1/2024	SUPPLEMENT FOR EXPANSION	$1,500,000
2024	2022	NEW YORK GENOME CENTER, INC.	101 AVENUE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	000	1	8/1/2024	NEW	$0
														Subtotal = $1,500,000

Issue Date FY: 2023 ( Subtotal = $1,500,000 )
2023	2023	NEW YORK GENOME CENTER, INC.	101 AVE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	001	1	8/25/2023	SUPPLEMENT FOR EXPANSION	$1,500,000
2023	2023	NEW YORK GENOME CENTER, INC.	101 AVE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	003	1	9/25/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	NEW YORK GENOME CENTER, INC.	101 AVE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	002	1	8/26/2023	NEW	$0
2023	2022	NEW YORK GENOME CENTER, INC.	101 AVE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	000	1	3/13/2023	NEW	$0
														Subtotal = $1,500,000

Issue Date FY: 2022 ( Subtotal = $1,450,265 )
2022	2022	NEW YORK GENOME CENTER, INC.	101 AVE OF THE AMERICAS FL 7	NEW YORK	NY	10013	NEW YORK	USA	Trans-NIH Research Support	000	1	7/30/2022	NEW	$1,450,265
														Subtotal = $1,450,265

Grand Total All Awards = $6,098,553

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Comprehensive reference atlas construction, geolocation and data integration for HuBMAP HIVE [5 of 5]

Award Number: OT2OD033760

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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